A coherence-based correction method was proposed in order to improve the lateral resolution and enhance the contrast of medical ultrasound imaging in the presence of phase aberration. The averaged coherence factor was...A coherence-based correction method was proposed in order to improve the lateral resolution and enhance the contrast of medical ultrasound imaging in the presence of phase aberration. The averaged coherence factor was proposed at first and used as a metric to evaluate phase aberration correction. By maximizing the averaged coherence factor, the time delay parameter of each channel was adjusted. A new set of coherence factors was calculated and the corrected data was optimized to form the final B-mode image. The simulations on point targets and a cyst phantom showed that the proposed method outperformed the nearest neighboring cross correlation method and conventional coherence-weighting method, and the lateral resolution and contrast ratio was improved by approximately 0.24mm and 18dB respectively. The proposed method combined the advantages of phase error correction and coherence-weighting, which could improve imaging qualities effectively in medical ultrasound.展开更多
Structured light,where complex optical fields are tailored in all their degrees of freedom,has become highly topical of late,advanced by a sophisticated toolkit comprising both linear and nonlinear optics.Removing und...Structured light,where complex optical fields are tailored in all their degrees of freedom,has become highly topical of late,advanced by a sophisticated toolkit comprising both linear and nonlinear optics.Removing undesired structure from light is far less developed,leveraging mostly on inverting the distortion,e.g.,with adaptive optics or the inverse transmission matrix of a complex channel,both requiring that the distortion be fully characterized through appropriate measurement.We show that distortions in spatially structured light can be corrected through difference-frequency generation in a nonlinear crystal without any need for the distortion to be known.We demonstrate the versatility of our approach using a wide range of aberrations and structured light modes,including higher-order orbital angular momentum(OAM)beams,showing excellent recovery of the original undistorted field.To highlight the efficacy of this process,we deploy the system in a prepare-and-measure communications link with OAM,showing minimal cross talk even when the transmission channel is highly aberrated,and outline how the approach could be extended to alternative experimental modalities and nonlinear processes.Our demonstration of light-correcting light without the need for measurement opens an approach to measurement-free error correction for classical and quantum structured light,with direct applications in imaging,sensing,and communication.展开更多
This paper proposes a new method that reconstructs the information of specimen by using random phase shift step in digital holographic microscopy (DHM). The principles of the method are described and discussed in deta...This paper proposes a new method that reconstructs the information of specimen by using random phase shift step in digital holographic microscopy (DHM). The principles of the method are described and discussed in detail. In practical experiment, because the phase shifter is neither perfectly linear nor calibrated, digital holograms with inaccurate phase shift step are recorded by the charge-coupled device (CCD). The phase could be accurately reconstructed from the recorded digital holograms by using the random phase-shifting algorithm, which makes up for reconstructed phase error caused by ordinary phase-shifting algorithm. The phase aberration compensation is also discussed. In order to verify the flexibility of the proposed method, numerical simulation of random phase-shifting DHM was carried out. The simulation results illustrated that the presented method is effective when the phase shift step is unknown or random in DHM.展开更多
We report a novel stimulated Raman scattering(SRS)microscopy technique featuring phase-controlled light focusing and aberration corrections for rapid,deep tissue 3D chemical imaging with subcellular resolution.To acco...We report a novel stimulated Raman scattering(SRS)microscopy technique featuring phase-controlled light focusing and aberration corrections for rapid,deep tissue 3D chemical imaging with subcellular resolution.To accomplish phasecontrolled SRS(PC-SRS),we utilize a single spatial light modulator to electronically tune the axial positioning of both the shortened-length Bessel pump and the focused Gaussian Stokes beams,enabling z-scanning-free optical sectioning in the sample.By incorporating Zernike polynomials into the phase patterns,we simultaneously correct the system aberrations at two separate wavelengths(~240 nm difference),achieving a~3-fold enhancement in signal-to-noise ratio over the uncorrected imaging system.PC-SRS provides>2-fold improvement in imaging depth in various samples(e.g.,polystyrene bead phantoms,porcine brain tissue)as well as achieves SRS 3D imaging speed of~13 Hz per volume for real-time monitoring of Brownian motion of polymer beads in water,superior to conventional point-scanning SRS 3D imaging.We further utilize PC-SRS to observe the metabolic activities of the entire tumor liver in living zebrafish in cellsilent region,unraveling the upregulated metabolism in liver tumor compared to normal liver.This work shows that PCSRS provides unprecedented insights into morpho-chemistry,metabolic and dynamic functioning of live cells and tissue in real-time at the subcellular level.展开更多
This article theoretically studies the influence of inhomogeneous abdominal walls on focused therapeutic ultrasound based on the phase screen model. An inhomogeneous tissue is considered as a combination of a homogene...This article theoretically studies the influence of inhomogeneous abdominal walls on focused therapeutic ultrasound based on the phase screen model. An inhomogeneous tissue is considered as a combination of a homogeneous medium and a phase aberration screen. Variations of acoustic parameters such as peak positive pressure, peak negative pressure, and acoustic intensity are discussed with respect to the phase screen statistics of human abdominal walls. Results indicate that the abdominal wall can result in energy loss of the sound in the focal plane. For a typical human abdominal wall with correlation length of 7.9 mm and variance of 0.36, the peak acoustic intensity radiated from a 1MHz transmitter with a radius of 30 mm can be reduced by about 14% at the focal plane.展开更多
基金国家自然科学基金(5167516061171048)+5 种基金河北省应用基础研究计划重点基础研究(15961701D)河北省高层次人才资助(GCC2014049)河北省人才工程培养经费(A201500503)天津市科技计划项目(15PTSYJC00260)江苏省双创人才资助项目European Horizon 2020 through Marie Sklodowska-Curie Individual Fellowship Scheme(707466-3DRM)项目资助
基金supported by the National Natural Science Foundation of China(11204346)
文摘A coherence-based correction method was proposed in order to improve the lateral resolution and enhance the contrast of medical ultrasound imaging in the presence of phase aberration. The averaged coherence factor was proposed at first and used as a metric to evaluate phase aberration correction. By maximizing the averaged coherence factor, the time delay parameter of each channel was adjusted. A new set of coherence factors was calculated and the corrected data was optimized to form the final B-mode image. The simulations on point targets and a cyst phantom showed that the proposed method outperformed the nearest neighboring cross correlation method and conventional coherence-weighting method, and the lateral resolution and contrast ratio was improved by approximately 0.24mm and 18dB respectively. The proposed method combined the advantages of phase error correction and coherence-weighting, which could improve imaging qualities effectively in medical ultrasound.
基金the funding from the Department of Science and Innovation as well as the National Research Foundation in South AfricaSupport from the Italian Ministry of Research(MUR)through the PRIN 2017 project“Interacting photons in polariton circuits”(INPho POL)and the PNRR MUR project PE0000023-NQSTI is acknowledgedsupport from the Italian Space Agency through the“Highdimensional quantum information”project
文摘Structured light,where complex optical fields are tailored in all their degrees of freedom,has become highly topical of late,advanced by a sophisticated toolkit comprising both linear and nonlinear optics.Removing undesired structure from light is far less developed,leveraging mostly on inverting the distortion,e.g.,with adaptive optics or the inverse transmission matrix of a complex channel,both requiring that the distortion be fully characterized through appropriate measurement.We show that distortions in spatially structured light can be corrected through difference-frequency generation in a nonlinear crystal without any need for the distortion to be known.We demonstrate the versatility of our approach using a wide range of aberrations and structured light modes,including higher-order orbital angular momentum(OAM)beams,showing excellent recovery of the original undistorted field.To highlight the efficacy of this process,we deploy the system in a prepare-and-measure communications link with OAM,showing minimal cross talk even when the transmission channel is highly aberrated,and outline how the approach could be extended to alternative experimental modalities and nonlinear processes.Our demonstration of light-correcting light without the need for measurement opens an approach to measurement-free error correction for classical and quantum structured light,with direct applications in imaging,sensing,and communication.
基金Supported by the National Basic Research Program of China("973"Project)(Grant No.2004CB619304)the National Natural Science Foundation of China(Grant Nos.10625209,10472050,10732080)+2 种基金the Project of Beijing Natural Sciences Foundation(Grant No.3072007)the Program for New Century Excellent Talents(NCET)in Chinese University Ministry of Education(Grant No.NCET-05-0059)the Opening Funds from the State Key Laboratory of Explosion Science and Technology
文摘This paper proposes a new method that reconstructs the information of specimen by using random phase shift step in digital holographic microscopy (DHM). The principles of the method are described and discussed in detail. In practical experiment, because the phase shifter is neither perfectly linear nor calibrated, digital holograms with inaccurate phase shift step are recorded by the charge-coupled device (CCD). The phase could be accurately reconstructed from the recorded digital holograms by using the random phase-shifting algorithm, which makes up for reconstructed phase error caused by ordinary phase-shifting algorithm. The phase aberration compensation is also discussed. In order to verify the flexibility of the proposed method, numerical simulation of random phase-shifting DHM was carried out. The simulation results illustrated that the presented method is effective when the phase shift step is unknown or random in DHM.
基金Natural Science Foundation of Zhejiang Province(Y1110125)Program for Innovative Research Team,Zhejiang Normal University,Jinhua,Zhejiang Province,P.R.China
基金supported by the Academic Research Fund(AcRF)from the Ministry of Education(MOE)(Tier 2(A-8000117-01-00)Tier 1(R397-000-334-114,R397-000-371-114,and R397-000-378-114)2024 Tsinghua-NUS Joint Research Initiative Fund,and the National Medical Research Council(NMRC)(A-0009502-01-00,and A-8001143-00-00),Singapore.
文摘We report a novel stimulated Raman scattering(SRS)microscopy technique featuring phase-controlled light focusing and aberration corrections for rapid,deep tissue 3D chemical imaging with subcellular resolution.To accomplish phasecontrolled SRS(PC-SRS),we utilize a single spatial light modulator to electronically tune the axial positioning of both the shortened-length Bessel pump and the focused Gaussian Stokes beams,enabling z-scanning-free optical sectioning in the sample.By incorporating Zernike polynomials into the phase patterns,we simultaneously correct the system aberrations at two separate wavelengths(~240 nm difference),achieving a~3-fold enhancement in signal-to-noise ratio over the uncorrected imaging system.PC-SRS provides>2-fold improvement in imaging depth in various samples(e.g.,polystyrene bead phantoms,porcine brain tissue)as well as achieves SRS 3D imaging speed of~13 Hz per volume for real-time monitoring of Brownian motion of polymer beads in water,superior to conventional point-scanning SRS 3D imaging.We further utilize PC-SRS to observe the metabolic activities of the entire tumor liver in living zebrafish in cellsilent region,unraveling the upregulated metabolism in liver tumor compared to normal liver.This work shows that PCSRS provides unprecedented insights into morpho-chemistry,metabolic and dynamic functioning of live cells and tissue in real-time at the subcellular level.
基金Project supported by the Program for New Century Excellent Talents in University of China (Grant No 06-0450)the National Natural Science Foundation of China (Grant No 10774071)the Natural Science Foundation of Jiangsu Province, China (Grant No BK2007518)
文摘This article theoretically studies the influence of inhomogeneous abdominal walls on focused therapeutic ultrasound based on the phase screen model. An inhomogeneous tissue is considered as a combination of a homogeneous medium and a phase aberration screen. Variations of acoustic parameters such as peak positive pressure, peak negative pressure, and acoustic intensity are discussed with respect to the phase screen statistics of human abdominal walls. Results indicate that the abdominal wall can result in energy loss of the sound in the focal plane. For a typical human abdominal wall with correlation length of 7.9 mm and variance of 0.36, the peak acoustic intensity radiated from a 1MHz transmitter with a radius of 30 mm can be reduced by about 14% at the focal plane.
