AIM：To compare the efficacy of selective laser trabeculoplasty（SLT） in replacing medical therapy in pseudophakic and phakic eyes.METHODS：Subgroup of a prospective randomized clinical trial including patients with ...AIM：To compare the efficacy of selective laser trabeculoplasty（SLT） in replacing medical therapy in pseudophakic and phakic eyes.METHODS：Subgroup of a prospective randomized clinical trial including patients with primary open angle glaucoma or ocular hypertension controlled with medication.Of 38 pseudophakic eyes were matched with 38 phakic eyes.SLT was offered as a way to decrease medication while maintaining the same low eye pressure.SLT was performed over 360°,at 3ns,spotsize 400 μm,100 spots.Data [intraocular pressure（IOP）,number of medications needed] were measured at 1h,1wk,1,3,6 and 12 mo.An independent-samples t-test was performed to compare baseline characteristics of the phakic and the pseudophakic group and differences in evolution of mean IOP and number of used medications.Chi-squared analysis was performed to investigate proportions of fast,slow and non-responders.RESULTS：The mean IOP measurement was 13.00± 2.88 mm Hg in the phakic group（38 eyes） and 13.51±3.06 mm Hg in the pseudophakic group（38 eyes）（P〉0.05）.This changed little after SLT and IOP lowering effect was comparable between the two groups.Main aim however was to lower the amount of medication needed.In the phakic group medication lowered from 1.29±0.62 at baseline,to 0.15±0.46 after 12mo;a reduction of 88.37%.In the pseudophakic group,used medication changed from 1.71±1.04,to 0.41±0.61;a 76.02% reduction.The differences were not statistically significant at any time point（P〉0.05）.IOP lowering occurred slightly faster in thepseudophakic group（50% of patients after one week） than in the phakic group（68% of patients after more than 4wk）.The difference was not significant（P〉0.05）.CONCLUSION：IOP lowering effect of SLT is comparable between phakic and pseudophakic eyes.展开更多
文摘AIM：To compare the efficacy of selective laser trabeculoplasty（SLT） in replacing medical therapy in pseudophakic and phakic eyes.METHODS：Subgroup of a prospective randomized clinical trial including patients with primary open angle glaucoma or ocular hypertension controlled with medication.Of 38 pseudophakic eyes were matched with 38 phakic eyes.SLT was offered as a way to decrease medication while maintaining the same low eye pressure.SLT was performed over 360°,at 3ns,spotsize 400 μm,100 spots.Data [intraocular pressure（IOP）,number of medications needed] were measured at 1h,1wk,1,3,6 and 12 mo.An independent-samples t-test was performed to compare baseline characteristics of the phakic and the pseudophakic group and differences in evolution of mean IOP and number of used medications.Chi-squared analysis was performed to investigate proportions of fast,slow and non-responders.RESULTS：The mean IOP measurement was 13.00± 2.88 mm Hg in the phakic group（38 eyes） and 13.51±3.06 mm Hg in the pseudophakic group（38 eyes）（P〉0.05）.This changed little after SLT and IOP lowering effect was comparable between the two groups.Main aim however was to lower the amount of medication needed.In the phakic group medication lowered from 1.29±0.62 at baseline,to 0.15±0.46 after 12mo;a reduction of 88.37%.In the pseudophakic group,used medication changed from 1.71±1.04,to 0.41±0.61;a 76.02% reduction.The differences were not statistically significant at any time point（P〉0.05）.IOP lowering occurred slightly faster in thepseudophakic group（50% of patients after one week） than in the phakic group（68% of patients after more than 4wk）.The difference was not significant（P〉0.05）.CONCLUSION：IOP lowering effect of SLT is comparable between phakic and pseudophakic eyes.
文摘目的研究CASIA2优化的NK和KS公式预测ICL(V4c)拱高与实际拱高的一致性。设计诊断技术评价。研究对象合肥爱尔眼科医院行ICL植入手术患者68例(68眼)。方法应用Nomogram在线公式计算68眼ICL型号,根据在线公式推荐结果分为12.1 mm、12.6 mm、13.2 mm ICL三组,再采用CASIA2测量以上三种型号组术后1天实际拱高(V1d12.1、V1d12.6、V1d13.2)、术后1个月实际拱高(V1m12.1、V1m12.6、V1m13.2),分别计算与CASIA2术前应用NK、KS公式预测拱高值的差异性、相关性和一致性,以及CASIA2内置的NK、KS公式术前推荐的ICL(V4c)型号与在线公式推荐的ICL(V4c)型号之间的符合率。主要指标实际拱高与公式预测拱高的相关性和一致性。结果全部术眼(68眼)术后1天实际拱高为(528.8±176.9)μm,术后1个月有所降低,为(476.8±161.2)μm。NK公式预测拱高为(656.2±204.5)μm,KS公式为(707.1±173.8)μm。Nomogram在线公式与NK公式之间总符合率为55.88%,与KS公式总符合率为42.65%。3种型号ICL(V4c)组术后1天实际拱高(V1d12.1、V1d12.6、V1d13.2)和1个月的实际拱高(V1m12.1、V1m12.6、V1m13.2)分别与NK公式预测拱高(VNK)、KS公式预测拱高(VKS)之间比较,除了V1d12.1组与VKS组拱高差异无统计学意义(t=-2.056,P=0.079)外,其余各型号组实际拱高均低于NK公式和KS公式预测的拱高(P均<0.05)。NK公式、KS公式的预测拱高与V1d均呈线性关系(Y=0.4728*X+218.6,Y=0.5450*X+143.4);与V1m也均呈线性关系(Y=0.3985*X+215.3,Y=0.4604*X+151.2)。68例患者术后V1d与NK公式、KS公式预测的拱高之间组内相关系数(ICC)分别为0.541、0.536,克隆巴赫系数分别为0.702、0.700;术后V1m与NK公式、KS公式预测拱高之间ICC分别为0.492、0.495,克隆巴赫系数分别为0.659、0.662。Bland-Altman分析V1d与NK公式、KS公式预测的拱高之间95%LoA分别为-486.5~231.7μm、-509.6~153.0μm,V1m与NK公式、KS公式预测的拱高之间95%LoA分别为-543.4~184.5μm、-560.6~99.86μm。�
