In this paper, the authors present airflow field characteristics of human upper airway and soft palate movement attitude during breathing. On the basis of the data taken from the spiral computerized tomography images ...In this paper, the authors present airflow field characteristics of human upper airway and soft palate movement attitude during breathing. On the basis of the data taken from the spiral computerized tomography images of a healthy person and a patient with Obstructive Sleep Apnea-Hypopnea Syndrome （OSAHS）, three-dimensional models of upper airway cavity and soft palate are reconstructed by the method of surface rendering. Numerical simulation is performed for airflow in the upper airway and displacement of soft palate by fluid-structure interaction analysis. The reconstructed threedimensional models precisely preserve the original configuration of upper airways and soft palate. The results of the pressure and velocity distributions in the airflow field are quantitatively determined, and the displacement of soft palate is presented. Pressure gradients of airway are lower for the healthy person and the airflow distribution is quite uniform in the case of free breathing. However, the OSAHS patient remarkably escalates both the pressure and velocity in the upper airway, and causes higher displacement of the soft palate. The present study is useful in revealing pathogenesis and quantitative mutual relationship between configuration and function of the upper airway as well as in diagnosingdiseases related to anatomical structure and function of the upper airway.展开更多
目的探索咽侧壁成形术联合软腭低温等离子消融治疗重度阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)的可行性和临床效果。方法收集整理我科2011年4月~2012年12月行咽侧壁成形术联合软腭低温等离...目的探索咽侧壁成形术联合软腭低温等离子消融治疗重度阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)的可行性和临床效果。方法收集整理我科2011年4月~2012年12月行咽侧壁成形术联合软腭低温等离子消融的21例重度OSAHS患者临床资料,并进行回顾性分析。结果治愈1例(5%),显效19例(90%),有效1例(5%),无效0例。术前平均呼吸暂停低通气指数(AHI)为(54.2±15.7)次/h,术后平均AHI为(8.3±2.8)次/h(t=-9.631,P<0.05);术前平均最低动脉血氧饱和度(lowest Sa O2,LSa O2)为(66.6±6.4)%,术后平均LSa O2为(78.6±5.6)%(t=4.689,P<0.05);术前Epwor t h嗜睡量表(Epwor t h sleepi ness score,ESS)平均评分为17.0±1.5,术后E S S平均评分为7.6±2.2(t=-11.376,P<0.05)。主观症状均明显改善,术后1个月随访未出现反流及吞咽困难。结论咽侧壁成形术联合软腭低温等离子消融术后患者AHI、LSa O2及ESS指标均改善明显,咽侧壁成形术联合软腭低温等离子消融可以作为治疗重度OSAHS的一个选择。展开更多
基金The project supported by the National Natural Science Foundation of China(10672036,10472025 and 10421002)the Natural Science Foundation of Liaoning Province(20032109)
文摘In this paper, the authors present airflow field characteristics of human upper airway and soft palate movement attitude during breathing. On the basis of the data taken from the spiral computerized tomography images of a healthy person and a patient with Obstructive Sleep Apnea-Hypopnea Syndrome （OSAHS）, three-dimensional models of upper airway cavity and soft palate are reconstructed by the method of surface rendering. Numerical simulation is performed for airflow in the upper airway and displacement of soft palate by fluid-structure interaction analysis. The reconstructed threedimensional models precisely preserve the original configuration of upper airways and soft palate. The results of the pressure and velocity distributions in the airflow field are quantitatively determined, and the displacement of soft palate is presented. Pressure gradients of airway are lower for the healthy person and the airflow distribution is quite uniform in the case of free breathing. However, the OSAHS patient remarkably escalates both the pressure and velocity in the upper airway, and causes higher displacement of the soft palate. The present study is useful in revealing pathogenesis and quantitative mutual relationship between configuration and function of the upper airway as well as in diagnosingdiseases related to anatomical structure and function of the upper airway.
文摘目的探索咽侧壁成形术联合软腭低温等离子消融治疗重度阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)的可行性和临床效果。方法收集整理我科2011年4月~2012年12月行咽侧壁成形术联合软腭低温等离子消融的21例重度OSAHS患者临床资料,并进行回顾性分析。结果治愈1例(5%),显效19例(90%),有效1例(5%),无效0例。术前平均呼吸暂停低通气指数(AHI)为(54.2±15.7)次/h,术后平均AHI为(8.3±2.8)次/h(t=-9.631,P<0.05);术前平均最低动脉血氧饱和度(lowest Sa O2,LSa O2)为(66.6±6.4)%,术后平均LSa O2为(78.6±5.6)%(t=4.689,P<0.05);术前Epwor t h嗜睡量表(Epwor t h sleepi ness score,ESS)平均评分为17.0±1.5,术后E S S平均评分为7.6±2.2(t=-11.376,P<0.05)。主观症状均明显改善,术后1个月随访未出现反流及吞咽困难。结论咽侧壁成形术联合软腭低温等离子消融术后患者AHI、LSa O2及ESS指标均改善明显,咽侧壁成形术联合软腭低温等离子消融可以作为治疗重度OSAHS的一个选择。
