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P70S6K在Xp11.2易位/TFE3基因融合相关性肾癌中的表达及临床意义 被引量:4
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作者 方伟建 龚伟 +3 位作者 朱忆凌 毛卫波 黄渊 陈国荣 《临床与实验病理学杂志》 CAS CSCD 北大核心 2016年第4期392-395,共4页
目的检测P70S6K在Xp11.2易位/TFE3基因融合相关性肾癌(renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion,TFE3 RCC)中的表达,探讨其在TFE3 RCC发生、发展中的作用及临床意义。方法采用免疫组化法检测23例... 目的检测P70S6K在Xp11.2易位/TFE3基因融合相关性肾癌(renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion,TFE3 RCC)中的表达,探讨其在TFE3 RCC发生、发展中的作用及临床意义。方法采用免疫组化法检测23例确诊的TFE3 RCC、14例肾透明细胞癌(clear cell RCC,CCRCC)和6例乳头状肾细胞癌(papillary RCC,PRCC)组织中P70S6K的表达,观察其表达与三种RCC的关系,同时观察P70S6K表达与TFE3 RCC发生、发展和相关临床病理参数的关系。结果 P70S6K在TFE3 RCC组织中的表达(91.3%)明显高于其在CCRCC组织(64.2%)和PRCC组织中的表达(66.6%),差异有显著性(P<0.05)。P70S6K在TFE3 RCC组织中阳性表达水平的H-score评分值(88.2±9.8)亦显著高于其在CCRCC组织(54.4±7.6)和PRCC组织(43.7±6.2)中阳性表达水平的H-score评分值,差异具有显著性(P<0.05)。P70S6K表达与TFE3 RCC患者年龄、有无淋巴结转移和脉管瘤栓有关,与患者性别、肿瘤直径等临床病理参数无关。结论与CCRCC和PRCC组织相比,TFE3 RCC组织中P70S6K表达显著增高,有助于TFE3 RCC的鉴别诊断。P70S6K在TFE3 RCC组织中高表达,同时提示mTOR信号通道在TFE3 RCC的发生、发展中可能起重要作用。为TFE3 RCC的靶向治疗寻找潜在药物靶点提供一定的理论基础。 展开更多
关键词 肾肿瘤 肾细胞癌 p70S6k MTOR TFE3
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Activation of the Akt/mTOR signaling pathway:a potential response to long-term neuronal loss in the hippocampus after sepsis 被引量:1
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作者 Jia-nan Guo Lin-yu Tian +2 位作者 Wen-yu Liu lie Mu Dong Zhou 《Neural Regeneration Research》 SCIE CAS CSCD 2017年第11期1832-1842,共11页
Survivors of sepsis may suffer chronic cognitive impairment as a long-term sequela. However, the precise mechanisms of cognitive dys- function after sepsis are not well understood. We employed the cecal ligation-and-p... Survivors of sepsis may suffer chronic cognitive impairment as a long-term sequela. However, the precise mechanisms of cognitive dys- function after sepsis are not well understood. We employed the cecal ligation-and-puncture-induced septic mouse model. We observed elevated phosphorylation of Akt, mammalian target of rapamycin (roTOR) and p70S6K on days 14 and 60, progressive neuronal loss in the cornu ammonis 1 region, and abnormal neuronal morphology in the hippocampus in the sepsis mouse model, These findings indicate that changes in neuronal morphology and number in the hippocampus after sepsis were associated with strong activation of the Akt/mTOR sig- naling pathway, and may reflect a "self-rescuing" feedback response to neuronal loss after sepsis. 展开更多
关键词 nerve regeneration SEpSIS cognitive impairment Akt mTOR p 7os6k HIppOCAMpUS neurons pHospHORYLATION neural hypertrophy neural regeneration
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Phosphorylated p70S6K in urothelial carcinoma of the tumor recurrence noninvasive low-grade bladder: correlation with
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作者 Soon-Ja Kim Jung Hoon Kim +3 位作者 Hui Seok Jung Tae-Jin Lee Kyung Mee Lee In Ho Chang 《Asian Journal of Andrology》 SCIE CAS CSCD 2014年第4期611-617,共7页
We investigated whether inhibiting phosphorylated p70S6K (p-p70S6K) suppresses the proliferation and growth of noninvasive low-grade urothelial carcinoma (LG-URCa) in vitro and whether p-p70S6K can serve as a pred... We investigated whether inhibiting phosphorylated p70S6K (p-p70S6K) suppresses the proliferation and growth of noninvasive low-grade urothelial carcinoma (LG-URCa) in vitro and whether p-p70S6K can serve as a predictive biomarker for the recurrence of noninvasive LG-URCa of the bladder in patients. We constructed a tissue microarray (TMA) for 95 LG-URCa and 35 benign urothelium samples and performed immunohistochemical staining for p-p70S6K and p-4E-BP1. A Cox regression model was used to investigate the predictive factors for recurrence of LG-URCa. We investigated the dose-dependent antiproliferative effect of rapamycin, its antiproliferative effect and the growth-inhibition effect of p70S6K siRNA transfection in RT4 and 253J cell lines. The pT1 staged group (P 〈 0.05; hazard ratio (HR), 2.415) and the high p-p70S6K staining group (P 〈 0.05; HR, 2.249) were independent factors for predicting recurrence. Rapamycin inhibited RT4 and 253J cell proliferation in a dose-dependent manner (r = -0.850, P 〈 0.001 in RT4 cells; r = -0.835, P 〈 0.001 in 253J cells). RT4 and 253J cell proliferation and growth were inhibited by the transfection of p70S6K siRNA and rapamycin, respectively (P 〈 0.05). Transfection of p70S6K siRNA resulted in inhibitory effects on cell proliferation and growth that were similar to those of rapamycin. Our results suggest that inhibiting p70S6K phosphorylation is important to prevent recurrence and that p70S6K phosphorylation can be used as a molecular biomarker to predict recurrence of certain LG-URCa of the bladder. 展开更多
关键词 BLADDER CANCER p7os6k
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