The oxygen therapy is a universal treatment in the hospital setting, especially in the critical care units. The purpose of this therapy is to avoid hypoxemia and to ensure an adequate supply of oxygen to the tissues. ...The oxygen therapy is a universal treatment in the hospital setting, especially in the critical care units. The purpose of this therapy is to avoid hypoxemia and to ensure an adequate supply of oxygen to the tissues. But often we overlook the potential adverse effects of oxygen therapy. Oxygen produces lung damage and induces apoptosis and cell death creating an imbalance between the production of reactive species of oxygen and the antioxidant mechanisms. The oxygen therapy inhibits systemic adaptive changes induced by hypoxia, disrupting compensatory mechanisms and causing deleterious effects. We are faced with a challenge in order to treat patients with respiratory failure, counterbalancing hypoxia with hyperoxia-induced damage and introducing therapy lines that are innovative but not risk-free as permissive hypoxemia. Currently many questions remain unresolved and there are not enough clinical studies that validate the therapeutic optimal oxygenation ranges. These ranges may differ depending on each patient and the underlying disease.展开更多
目的观察乙酰唑胺引起的脑血流变化对脑型氧中毒的影响。方法腹腔注射乙酰唑胺并观察其对脑型氧中毒（central nervous system oxygen toxicity，CNS—OT）潜伏期的影响，测定腹腔注射乙酰唑胺后脑血流变化和脑组织氧化损伤状况，并观...目的观察乙酰唑胺引起的脑血流变化对脑型氧中毒的影响。方法腹腔注射乙酰唑胺并观察其对脑型氧中毒（central nervous system oxygen toxicity，CNS—OT）潜伏期的影响，测定腹腔注射乙酰唑胺后脑血流变化和脑组织氧化损伤状况，并观察对脑组织谷氨酸脱羧酶（GAD）含量的影响.结果腹腔注射乙酰唑胺显著缩短CNS—OT潜伏期（P〈0．05，P〈0．01），增加脑血流量（P〈0．01），加重脑组织氧化损伤，脑组织中的丙二醛（MDA）显著增多（P〈0．05），并减少GAD含量（P〈0．01）。结论腹腔注射乙酰唑胺通过扩张脑血管加重氧化损伤并减少GAD，进而促进急性氧中毒的发生.展开更多
文摘The oxygen therapy is a universal treatment in the hospital setting, especially in the critical care units. The purpose of this therapy is to avoid hypoxemia and to ensure an adequate supply of oxygen to the tissues. But often we overlook the potential adverse effects of oxygen therapy. Oxygen produces lung damage and induces apoptosis and cell death creating an imbalance between the production of reactive species of oxygen and the antioxidant mechanisms. The oxygen therapy inhibits systemic adaptive changes induced by hypoxia, disrupting compensatory mechanisms and causing deleterious effects. We are faced with a challenge in order to treat patients with respiratory failure, counterbalancing hypoxia with hyperoxia-induced damage and introducing therapy lines that are innovative but not risk-free as permissive hypoxemia. Currently many questions remain unresolved and there are not enough clinical studies that validate the therapeutic optimal oxygenation ranges. These ranges may differ depending on each patient and the underlying disease.
文摘目的观察乙酰唑胺引起的脑血流变化对脑型氧中毒的影响。方法腹腔注射乙酰唑胺并观察其对脑型氧中毒（central nervous system oxygen toxicity，CNS—OT）潜伏期的影响，测定腹腔注射乙酰唑胺后脑血流变化和脑组织氧化损伤状况，并观察对脑组织谷氨酸脱羧酶（GAD）含量的影响.结果腹腔注射乙酰唑胺显著缩短CNS—OT潜伏期（P〈0．05，P〈0．01），增加脑血流量（P〈0．01），加重脑组织氧化损伤，脑组织中的丙二醛（MDA）显著增多（P〈0．05），并减少GAD含量（P〈0．01）。结论腹腔注射乙酰唑胺通过扩张脑血管加重氧化损伤并减少GAD，进而促进急性氧中毒的发生.
