Objective To investigate the effects of short-term forest bathing on human health. Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10. One group wa...Objective To investigate the effects of short-term forest bathing on human health. Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10. One group was sent on a two-night trip to a broad-leaved evergreen forest, and the other was sent to a city area. Serum cytokine levels reflecting inflammatory and stress response, indicators reflecting oxidative stress, the distribution of leukocyte subsets, and plasma endothelin-1 （ET-1） concentrations were measured before and after the experiment to evaluate the positive health effects of forest environments. A profile of mood states （POMS） evaluation was used to assess changes in mood states. Results No significant differences in the baseline values of the indicators were observed between the two groups before the experiment. Subjects exposed to the forest environment showed reduced oxidative stress and pro-inflammatory level, as evidenced by decreased malondialdehyde, interleukin-6, and tumor necrosis factor a levels compared with the urban group. Serum cortisol levels were also lower than in the urban group. Notably, the concentration of plasma ET-1 was much lower in subjects exposed to the forest environment. The POMS evaluation showed that after exposure to the forest environment, subjects had lower scores in the negative subscales, and the score for vigor was increased. Conclusion Forest bathing is beneficial to human health, perhaps through preventive effects related to several pathological factors.展开更多
目的探讨α-硫辛酸注射液对糖尿病肾病患者氧化应激和代谢指标的影响。方法回顾性选取2017年6月至2019年6月上海市东医院收治的糖尿病肾病患者200例,依据治疗方法分为两组:常规对症治疗组和α-硫辛酸注射液组,每组各100例。常规对症治...目的探讨α-硫辛酸注射液对糖尿病肾病患者氧化应激和代谢指标的影响。方法回顾性选取2017年6月至2019年6月上海市东医院收治的糖尿病肾病患者200例,依据治疗方法分为两组:常规对症治疗组和α-硫辛酸注射液组,每组各100例。常规对症治疗组患者采用常规对症方法治疗,α-硫辛酸注射液组患者在常规对症治疗的基础上联合α-硫辛酸注射液治疗。统计分析两组患者的谷胱甘肽(GSH)、超氧化物歧化酶(SOD)、丙二醛(MDA)、8-羟基脱氧鸟苷(8-OHd G)、糖化血红蛋白(Hb A1c)、空腹血糖(FPG)、三酰甘油(TG)、总胆固醇(TC)、视黄醇结合蛋白(RBP)、胱抑素C(Cys C)、24 h尿微量白蛋白(24 h m Alb)水平和临床疗效。结果α-硫辛酸注射液组患者治疗前的GSH、SOD、MDA、8-OHd G水平分别为(18.0±1.9)U/L、(114.6±12.5)U/L、(45.8±5.6)U/L、(62.2±7.6)U/L,治疗后分别为(23.4±3.4)U/L、(188.5±21.6)U/L、(27.2±4.0)U/L、(33.4±5.5)U/L;常规对症治疗组患者治疗前的GSH、SOD、MDA、8-OHd G水平分别为(18.4±2.2)U/L、(116.1±13.2)U/L、(46.1±5.3)U/L、(63.1±7.0)U/L,治疗后分别为(56.7±6.6)U/L、(312.5±36.3)U/L、(14.6±2.3)U/L、(19.6±2.4)U/L。α-硫辛酸注射液组患者治疗后较治疗前的GSH、SOD升高幅度、MDA、8-OHd G降低幅度均显著高于常规对症治疗组,差异具有统计学意义(P<0.05)。两组患者治疗前后的FPG、Hb A1c、TG、TC水平比较,差异均无统计学意义(P>0.05)。α-硫辛酸注射液组患者治疗后较治疗前的RBP、Cys C、24 h m Alb水平降低幅度均显著高于常规对症治疗组,差异具有统计学意义(P<0.05)。在治疗的总有效率方面,α-硫辛酸注射液组患者为91.0%(91/100),常规对症治疗组为64.0%(64/100),前者显著高于后者,差异具有统计学意义(P<0.05)。结论α-硫辛酸注射液能够有效降低糖尿病肾病患者的氧化应激水平和血糖、血脂水平,改善患者的肾功能,提升治疗的总有效率,值得�展开更多
基金supported by the project "Modern forestry-exploitation and utilization of therapeutic forest" commissioned by the Forestry Department of Zhejiang Provincefunds from the Ministry of Health of P.R.China (WKJ2011-2-014)+1 种基金the Science and Technology Department of Zhejiang Province Program (2008C33046)Zhejiang Provincial key disciplinary fields of Geriatrics Program (2007ZB006 and 2008ZJ004)
文摘Objective To investigate the effects of short-term forest bathing on human health. Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10. One group was sent on a two-night trip to a broad-leaved evergreen forest, and the other was sent to a city area. Serum cytokine levels reflecting inflammatory and stress response, indicators reflecting oxidative stress, the distribution of leukocyte subsets, and plasma endothelin-1 （ET-1） concentrations were measured before and after the experiment to evaluate the positive health effects of forest environments. A profile of mood states （POMS） evaluation was used to assess changes in mood states. Results No significant differences in the baseline values of the indicators were observed between the two groups before the experiment. Subjects exposed to the forest environment showed reduced oxidative stress and pro-inflammatory level, as evidenced by decreased malondialdehyde, interleukin-6, and tumor necrosis factor a levels compared with the urban group. Serum cortisol levels were also lower than in the urban group. Notably, the concentration of plasma ET-1 was much lower in subjects exposed to the forest environment. The POMS evaluation showed that after exposure to the forest environment, subjects had lower scores in the negative subscales, and the score for vigor was increased. Conclusion Forest bathing is beneficial to human health, perhaps through preventive effects related to several pathological factors.
文摘目的探讨α-硫辛酸注射液对糖尿病肾病患者氧化应激和代谢指标的影响。方法回顾性选取2017年6月至2019年6月上海市东医院收治的糖尿病肾病患者200例,依据治疗方法分为两组:常规对症治疗组和α-硫辛酸注射液组,每组各100例。常规对症治疗组患者采用常规对症方法治疗,α-硫辛酸注射液组患者在常规对症治疗的基础上联合α-硫辛酸注射液治疗。统计分析两组患者的谷胱甘肽(GSH)、超氧化物歧化酶(SOD)、丙二醛(MDA)、8-羟基脱氧鸟苷(8-OHd G)、糖化血红蛋白(Hb A1c)、空腹血糖(FPG)、三酰甘油(TG)、总胆固醇(TC)、视黄醇结合蛋白(RBP)、胱抑素C(Cys C)、24 h尿微量白蛋白(24 h m Alb)水平和临床疗效。结果α-硫辛酸注射液组患者治疗前的GSH、SOD、MDA、8-OHd G水平分别为(18.0±1.9)U/L、(114.6±12.5)U/L、(45.8±5.6)U/L、(62.2±7.6)U/L,治疗后分别为(23.4±3.4)U/L、(188.5±21.6)U/L、(27.2±4.0)U/L、(33.4±5.5)U/L;常规对症治疗组患者治疗前的GSH、SOD、MDA、8-OHd G水平分别为(18.4±2.2)U/L、(116.1±13.2)U/L、(46.1±5.3)U/L、(63.1±7.0)U/L,治疗后分别为(56.7±6.6)U/L、(312.5±36.3)U/L、(14.6±2.3)U/L、(19.6±2.4)U/L。α-硫辛酸注射液组患者治疗后较治疗前的GSH、SOD升高幅度、MDA、8-OHd G降低幅度均显著高于常规对症治疗组,差异具有统计学意义(P<0.05)。两组患者治疗前后的FPG、Hb A1c、TG、TC水平比较,差异均无统计学意义(P>0.05)。α-硫辛酸注射液组患者治疗后较治疗前的RBP、Cys C、24 h m Alb水平降低幅度均显著高于常规对症治疗组,差异具有统计学意义(P<0.05)。在治疗的总有效率方面,α-硫辛酸注射液组患者为91.0%(91/100),常规对症治疗组为64.0%(64/100),前者显著高于后者,差异具有统计学意义(P<0.05)。结论α-硫辛酸注射液能够有效降低糖尿病肾病患者的氧化应激水平和血糖、血脂水平,改善患者的肾功能,提升治疗的总有效率,值得�
