Glutathione S-transferases(GSTs) are a family of soluble detoxification enzymes which use reduced glutathione(GSH) in conjugation and reduction reactions.Toxic electrophiles,including a variety of carcinogens,are subs...Glutathione S-transferases(GSTs) are a family of soluble detoxification enzymes which use reduced glutathione(GSH) in conjugation and reduction reactions.Toxic electrophiles,including a variety of carcinogens,are substrates for the GSTs and are more easily excreted into bile or urine after conjugation or reduction .The three-dimensional structures of GSTs from several species,including humans,have been determined.GST activity has been found to present in all human tissues,and expression of the various GST isoenzymes differs in degree in the various tissues. Glutathione S-transferases may play a role in the protection of cells against toxic electrophiles and in the resistance to cancer chemotherapeutic agants.The polymorphisms of GSTs genes are one of the important factors that exercise influence on individual susceptibility to cancer.展开更多
文摘Glutathione S-transferases(GSTs) are a family of soluble detoxification enzymes which use reduced glutathione(GSH) in conjugation and reduction reactions.Toxic electrophiles,including a variety of carcinogens,are substrates for the GSTs and are more easily excreted into bile or urine after conjugation or reduction .The three-dimensional structures of GSTs from several species,including humans,have been determined.GST activity has been found to present in all human tissues,and expression of the various GST isoenzymes differs in degree in the various tissues. Glutathione S-transferases may play a role in the protection of cells against toxic electrophiles and in the resistance to cancer chemotherapeutic agants.The polymorphisms of GSTs genes are one of the important factors that exercise influence on individual susceptibility to cancer.
文摘目的:探讨多烯紫杉醇联合碘化油介入方案(多西他赛治疗方案)治疗肝癌的临床疗效。方法 :将原发中晚期肝癌43例按患者病例单双号随机分为A、B两组。A组(多西他赛治疗方案):22例,先注入地塞米松10 mg预防过敏反应,然后将多西他赛60 mg/m^2溶于100 m L 0.9%生理盐水中缓慢推注,再将5-FU 250 mg与5~20 m L碘油的混悬液缓慢注入栓塞,直至碘油在瘤灶内沉积浓密或血流缓慢。B组(常规化疗治疗方案组):21例,表柔比星(EADM)40~60 mg/m^2、丝裂霉素(MMC)8 mg/m^2、顺铂(DDP)60 mg/m^2、羟基喜树碱(HCPT)20 mg/m^2,以上化疗药物根据患者病情选出几种组合碘油。并观察比较肿瘤治疗后的近期疗效、患者生存期及并发症。结果:A组与B组6、12月生存率分别为94.5%、48.9%和91.6%、37.6%,两组生存率比较差异有显著性(P<O.05)。两组并发症无明显差别。结论:多西他赛方案治疗原发性肝癌较常规化疗方案组能更好的改善患者的近期生存质量,能在一定程度上延长患者的生存期。
