视觉倒置(upside-down reversal of vision,UDRV)是一种罕见的视物变形症或视觉错觉,能扭曲物体的大小、形状或倾斜程度的临床症状。其特征是患者的视觉图像在冠状位发生瞬时180°的倒置。迄今为止,UDRV在国内尚未见报道,但在国外...视觉倒置(upside-down reversal of vision,UDRV)是一种罕见的视物变形症或视觉错觉,能扭曲物体的大小、形状或倾斜程度的临床症状。其特征是患者的视觉图像在冠状位发生瞬时180°的倒置。迄今为止,UDRV在国内尚未见报道,但在国外文献的报道中,其严重影响患者视力和生活,给患者的心理带来了前所未有的冲击。本文讨论UDRV的潜在病因和临床特征,以期进一步提高临床医生对这种情况的认识,科学诊断和治疗,减少患者的心理困扰。尽管现有的UDRV研究有助于了解视觉形成的机制和可能的视觉调节机制,但具体的病因和机制尚不清楚。因此我们提出了一个视觉调控的假说“视觉独立调控中枢”来解释这种现象。展开更多
The secretory activities of meibomian glands are regulated by the autonomic nervous system, The change in density and activity of autonomic nerves in meibomian glands during menopause play an important role in the pat...The secretory activities of meibomian glands are regulated by the autonomic nervous system, The change in density and activity of autonomic nerves in meibomian glands during menopause play an important role in the pathogenesis of dry eye. In view of this, we established a dry eye rat model by removing the bilateral ovaries. We used neuropeptide Y and vasoactive intestinal polypeptide as markers of autonomic neurotransmitters. Our results showed that the concentration of estradiol in serum significantly decreased, the density of neuropeptide Y immunoreactivity in nerve fibers significantly increased, the density of vasoactive intestinal polypeptide immunoreactivity in nerve fibers significantly decreased, and the ratio of vasoactive intestinal polypeptide/neuropeptide Y positive staining significantly decreased. These results suggest that a decrease in ovary activity may lead to autonomic nervous system dysfunction, thereby affecting the secretory activity of the meibomian gland, which participates in sexual hormone imbalance-induced dry eye.展开更多
文摘视觉倒置(upside-down reversal of vision,UDRV)是一种罕见的视物变形症或视觉错觉,能扭曲物体的大小、形状或倾斜程度的临床症状。其特征是患者的视觉图像在冠状位发生瞬时180°的倒置。迄今为止,UDRV在国内尚未见报道,但在国外文献的报道中,其严重影响患者视力和生活,给患者的心理带来了前所未有的冲击。本文讨论UDRV的潜在病因和临床特征,以期进一步提高临床医生对这种情况的认识,科学诊断和治疗,减少患者的心理困扰。尽管现有的UDRV研究有助于了解视觉形成的机制和可能的视觉调节机制,但具体的病因和机制尚不清楚。因此我们提出了一个视觉调控的假说“视觉独立调控中枢”来解释这种现象。
基金supported by the Key Technology Research & Development Program of Hebei Province,No.10276105D-3the Key Project of Hebei Province Health Department of Medical Science,No.20120154the Key Technology Research & Development Program of Hebei Province Handan City,No.1023108101-2
文摘The secretory activities of meibomian glands are regulated by the autonomic nervous system, The change in density and activity of autonomic nerves in meibomian glands during menopause play an important role in the pathogenesis of dry eye. In view of this, we established a dry eye rat model by removing the bilateral ovaries. We used neuropeptide Y and vasoactive intestinal polypeptide as markers of autonomic neurotransmitters. Our results showed that the concentration of estradiol in serum significantly decreased, the density of neuropeptide Y immunoreactivity in nerve fibers significantly increased, the density of vasoactive intestinal polypeptide immunoreactivity in nerve fibers significantly decreased, and the ratio of vasoactive intestinal polypeptide/neuropeptide Y positive staining significantly decreased. These results suggest that a decrease in ovary activity may lead to autonomic nervous system dysfunction, thereby affecting the secretory activity of the meibomian gland, which participates in sexual hormone imbalance-induced dry eye.
