2009版NCCN直肠癌临床实践指南本年度共涉及14项更新,包括诊断、多学科评估、辅助化放疗、新辅助化放疗、晚期解救及靶向药物治疗等内容。其重点更新包括:直肠癌术前可切除性评估首次在正文中强调了应选择"硬性直肠镜"而非&qu...2009版NCCN直肠癌临床实践指南本年度共涉及14项更新,包括诊断、多学科评估、辅助化放疗、新辅助化放疗、晚期解救及靶向药物治疗等内容。其重点更新包括:直肠癌术前可切除性评估首次在正文中强调了应选择"硬性直肠镜"而非"直肠镜";明确K-ras基因野生型结直肠癌病人是靶向药物西妥昔单抗临床应用适应证人群;提出了微卫星不稳定性与预后和化疗敏感性的关系等。而2009年美国临床肿瘤学会年会主题所提出的"癌症医疗个体化(personalizing cancer care)"理念也在肿瘤领域引起重大反响,这一理念明确了除个体化治疗计划(personalized the rapy)外,"癌症医疗个体化"还包括了个体化癌症风险评估、个体化生存规划以及终末期病人姑息治疗和护理的个体化等内容。正确理解肿瘤诊治理念更新变化,强调科学客观的临床多学科评估,将成为推动直肠癌诊治水平的基础和保障。展开更多
Esophageal carcinoma is one of the most common malignant tumors, especially in China which is the high incidence area. As a result of mild symptoms of early-stage esophageal cancer, the majority of patients cannot be ...Esophageal carcinoma is one of the most common malignant tumors, especially in China which is the high incidence area. As a result of mild symptoms of early-stage esophageal cancer, the majority of patients cannot be diagnosed until they develop to advanced cancer, and the treatment outcome of surgery or chemoradiotherapy is still unsatisfactory at present. The guidelines of esophageal cancer issued by National Comprehensive Cancer Network (NCCN) are regarded as important reference tools by clinical oncologists, and provide uniform criteria for the diagnosis and treatment of esophageal carcinoma. However, the guidelines are not always suitable for Chinese patients because the data come from European and American population which have significant ethnical difference from Chinese. We retrospectively analyzed the changes of treatment strategy of esophageal cancer in NCCN guidelines and the advance of treatment for esophageal carcinoma in China, aiming to provide our oncologists with new research ideas. We also hope to set up clinical cancer cooperation organizations, and release our own cancer guidelines to serve Chinese patients and oncologists.展开更多
胰腺癌是预后极差的消化系统恶性肿瘤。美国国立综合癌症网络(National Comprehensive Cancer Network,NCCN)结合最新高质量循证医学证据不断更新推出胰腺癌的临床实践指南以指导胰腺癌的规范化诊疗。2023年5月4日与6月19日《NCCN胰腺...胰腺癌是预后极差的消化系统恶性肿瘤。美国国立综合癌症网络(National Comprehensive Cancer Network,NCCN)结合最新高质量循证医学证据不断更新推出胰腺癌的临床实践指南以指导胰腺癌的规范化诊疗。2023年5月4日与6月19日《NCCN胰腺癌临床实践指南》分别进行了两次更新。相较于2022年第2版,这两次更新主要集中于最新的免疫/靶向治疗进展、NALIRIFOX方案的引入以及体能状态中等病人治疗方案的补充。本文结合相关循证医学证据对最新《NCCN胰腺癌临床实践指南》的更新进行解读。展开更多
文摘2009版NCCN直肠癌临床实践指南本年度共涉及14项更新,包括诊断、多学科评估、辅助化放疗、新辅助化放疗、晚期解救及靶向药物治疗等内容。其重点更新包括:直肠癌术前可切除性评估首次在正文中强调了应选择"硬性直肠镜"而非"直肠镜";明确K-ras基因野生型结直肠癌病人是靶向药物西妥昔单抗临床应用适应证人群;提出了微卫星不稳定性与预后和化疗敏感性的关系等。而2009年美国临床肿瘤学会年会主题所提出的"癌症医疗个体化(personalizing cancer care)"理念也在肿瘤领域引起重大反响,这一理念明确了除个体化治疗计划(personalized the rapy)外,"癌症医疗个体化"还包括了个体化癌症风险评估、个体化生存规划以及终末期病人姑息治疗和护理的个体化等内容。正确理解肿瘤诊治理念更新变化,强调科学客观的临床多学科评估,将成为推动直肠癌诊治水平的基础和保障。
文摘Esophageal carcinoma is one of the most common malignant tumors, especially in China which is the high incidence area. As a result of mild symptoms of early-stage esophageal cancer, the majority of patients cannot be diagnosed until they develop to advanced cancer, and the treatment outcome of surgery or chemoradiotherapy is still unsatisfactory at present. The guidelines of esophageal cancer issued by National Comprehensive Cancer Network (NCCN) are regarded as important reference tools by clinical oncologists, and provide uniform criteria for the diagnosis and treatment of esophageal carcinoma. However, the guidelines are not always suitable for Chinese patients because the data come from European and American population which have significant ethnical difference from Chinese. We retrospectively analyzed the changes of treatment strategy of esophageal cancer in NCCN guidelines and the advance of treatment for esophageal carcinoma in China, aiming to provide our oncologists with new research ideas. We also hope to set up clinical cancer cooperation organizations, and release our own cancer guidelines to serve Chinese patients and oncologists.
文摘胰腺癌是预后极差的消化系统恶性肿瘤。美国国立综合癌症网络(National Comprehensive Cancer Network,NCCN)结合最新高质量循证医学证据不断更新推出胰腺癌的临床实践指南以指导胰腺癌的规范化诊疗。2023年5月4日与6月19日《NCCN胰腺癌临床实践指南》分别进行了两次更新。相较于2022年第2版,这两次更新主要集中于最新的免疫/靶向治疗进展、NALIRIFOX方案的引入以及体能状态中等病人治疗方案的补充。本文结合相关循证医学证据对最新《NCCN胰腺癌临床实践指南》的更新进行解读。
