A series of NaNdF4 nanocrystals was synthesized via a facile hydrothermal route with Nd（C3H7COO）yPhen and Nd（NO3）3·Phen （Phen, 1,10-phenanthroline） as the Nd precursors. Distinct effect of the neutral donor...A series of NaNdF4 nanocrystals was synthesized via a facile hydrothermal route with Nd（C3H7COO）yPhen and Nd（NO3）3·Phen （Phen, 1,10-phenanthroline） as the Nd precursors. Distinct effect of the neutral donor ligand （Phen） on the morphology of NaNdF4 nanocrystals was demonstrated. When Nd（C3H7COO）yPhen was chosen and the hydrothermal reaction temperature was controlled at 220 ℃, the NaNdF4 nanocrystals with uniform short nanorod shape were obtained. The sizes of the as-prepared nanorods could be tuned by changing the hydrothermal temperatures. This method provided a useful way for the preparation of sodium rare-earth fluoride nanocrystals with controlled shapes and sizes.展开更多
Multimodal imaging probes have attracted wide attention and have potential to diagnose diseases accurately because of the complementary advantages of multiple imaging modalities. However, intractable issues remain wit...Multimodal imaging probes have attracted wide attention and have potential to diagnose diseases accurately because of the complementary advantages of multiple imaging modalities. However, intractable issues remain with regard to their complicated multi-step fabrication for hybrid nanostructure and interference of different modal imaging. In the present stud we present, for the first time, T1 and T2-weighted magnetic resonance imaging （MRI） of ultrasmaU Mn2＋-doped NaNdF4 nanocrystals （NCs）, which can also be used simultaneously for second near infrared （NIR-U） fluorescence and computed tomography （CT） imaging, thus enabling high-performance multimodal MRI/NIR-II/CT imaging of single NaNdF4：Mn NCs. The NaNdF4：Mn was demonstrated as a nanoprobe for in vitro and in vivo multimodal MRI and NIR-II fluorescence imaging of human mesenchymal stem cells. The results provide a new strategy to simplify the nanostructure and preparation of probes, based on the features of NaNdF4：Mn NCs, which offer highly efficient multimodal MRI/NIR-II/CT imaging.展开更多
基金Project supported by the National Natural Science Foundation of China (60977023)One Hundred Talents Program of the Chinese Academy of Sciences
文摘A series of NaNdF4 nanocrystals was synthesized via a facile hydrothermal route with Nd（C3H7COO）yPhen and Nd（NO3）3·Phen （Phen, 1,10-phenanthroline） as the Nd precursors. Distinct effect of the neutral donor ligand （Phen） on the morphology of NaNdF4 nanocrystals was demonstrated. When Nd（C3H7COO）yPhen was chosen and the hydrothermal reaction temperature was controlled at 220 ℃, the NaNdF4 nanocrystals with uniform short nanorod shape were obtained. The sizes of the as-prepared nanorods could be tuned by changing the hydrothermal temperatures. This method provided a useful way for the preparation of sodium rare-earth fluoride nanocrystals with controlled shapes and sizes.
文摘Multimodal imaging probes have attracted wide attention and have potential to diagnose diseases accurately because of the complementary advantages of multiple imaging modalities. However, intractable issues remain with regard to their complicated multi-step fabrication for hybrid nanostructure and interference of different modal imaging. In the present stud we present, for the first time, T1 and T2-weighted magnetic resonance imaging （MRI） of ultrasmaU Mn2＋-doped NaNdF4 nanocrystals （NCs）, which can also be used simultaneously for second near infrared （NIR-U） fluorescence and computed tomography （CT） imaging, thus enabling high-performance multimodal MRI/NIR-II/CT imaging of single NaNdF4：Mn NCs. The NaNdF4：Mn was demonstrated as a nanoprobe for in vitro and in vivo multimodal MRI and NIR-II fluorescence imaging of human mesenchymal stem cells. The results provide a new strategy to simplify the nanostructure and preparation of probes, based on the features of NaNdF4：Mn NCs, which offer highly efficient multimodal MRI/NIR-II/CT imaging.
