Objective To inquire into the mechanism of toxic effect of nickel sulfate (NiSO 4) on heart, liver and kidney.Methods Several groups of rats were exposed to NiSO 4 at dose of 2.5,5 0, 10.0 mg/kg through intraperitonea...Objective To inquire into the mechanism of toxic effect of nickel sulfate (NiSO 4) on heart, liver and kidney.Methods Several groups of rats were exposed to NiSO 4 at dose of 2.5,5 0, 10.0 mg/kg through intraperitoneal infection for 10 days, the cell membrane of myocardium, liver and renal tubules were prepared to assess the activity of Na +·K + ATPase, Ca 2+ ATPase with spectrophotometric assay. Results The result showed that NiSO 4 was able to inhibit obviously the activity of Na +·K + ATPase, Ca 2+ ATPase of the three kinds of cell membrane, and its inhibitiue effect was shown to be the strongest in kidney and the weakest in liver.Conclusion The damage on rat’s heart, liver and kidney by NiSO 4 could be related to the inhibitive activity of cell membrane ATPase. However, the mechanism of toxic effect of nickel sulfate on heart, liver and kidney should be studied further.展开更多
文摘Objective To inquire into the mechanism of toxic effect of nickel sulfate (NiSO 4) on heart, liver and kidney.Methods Several groups of rats were exposed to NiSO 4 at dose of 2.5,5 0, 10.0 mg/kg through intraperitoneal infection for 10 days, the cell membrane of myocardium, liver and renal tubules were prepared to assess the activity of Na +·K + ATPase, Ca 2+ ATPase with spectrophotometric assay. Results The result showed that NiSO 4 was able to inhibit obviously the activity of Na +·K + ATPase, Ca 2+ ATPase of the three kinds of cell membrane, and its inhibitiue effect was shown to be the strongest in kidney and the weakest in liver.Conclusion The damage on rat’s heart, liver and kidney by NiSO 4 could be related to the inhibitive activity of cell membrane ATPase. However, the mechanism of toxic effect of nickel sulfate on heart, liver and kidney should be studied further.
