以支持NBS协议(NEMO basic support protocol)的移动网络为研究对象,针对移动性管理和路由优化问题,提出基于改进HMIPv6的移动网络路由优化方案.将HMIPv6与NBS整合并构建层次化网络架构,利用HMIPv6的区域化管理机制降低移动网络内的移...以支持NBS协议(NEMO basic support protocol)的移动网络为研究对象,针对移动性管理和路由优化问题,提出基于改进HMIPv6的移动网络路由优化方案.将HMIPv6与NBS整合并构建层次化网络架构,利用HMIPv6的区域化管理机制降低移动网络内的移动节点注册开销.对HMIPv6进行改进,设计全新移动网络路由优化方案,消除移动网络内部节点通信过程中所存在的冗余路由.分析结果表明,同NBS对比,本方案在额外数据包开销和移动管理开销方面具有显著优势.展开更多
代理移动IPv6是基于网络的移动性管理方案,其标准RFC5213中只规范了对单个节点的移动性支持,缺乏对子网移动的研究。研究了现有的3种代理移动IPv6下基于隧道的子网移动方案,重点分析了代理移动IPv6下采用隧道分离思想的移动子网实现方法...代理移动IPv6是基于网络的移动性管理方案,其标准RFC5213中只规范了对单个节点的移动性支持,缺乏对子网移动的研究。研究了现有的3种代理移动IPv6下基于隧道的子网移动方案,重点分析了代理移动IPv6下采用隧道分离思想的移动子网实现方法 N-NEMO(network based NEMO),并在Linux环境下采用C语言对3种方案分别给予实现,对3种子网移动方案进行性能分析和对比,结果表明,虽然N-NEMO的切换时延较大且信令较为复杂,但是具有网络层头部开销小及支持节点类型全面的优点。展开更多
The NS5A non-structural protein of classical swine fever virus(CSFV)is a multifunctional protein involved in viral genomic replication,protein translation,assembly of infectious virus particles,and regulation of cellu...The NS5A non-structural protein of classical swine fever virus(CSFV)is a multifunctional protein involved in viral genomic replication,protein translation,assembly of infectious virus particles,and regulation of cellular signaling pathways.Previous report showed that NS5A inhibited nuclear factor kappa B(NF-κB)signaling induced by poly(I:C);however,the mechanism involved has not been elucidated.Here,we reported that NS5A directly interacted with NF-κB essential modulator(NEMO),a regulatory subunit of the IκB kinase(IKK)complex,to inhibit the NF-κB signaling pathway.Further investigations showed that the zinc finger domain of NEMO and the aa 126–250 segment of NS5A are essential for the interaction between NEMO and NS5A.Mechanistic analysis revealed that NS5A mediated the proteasomal degradation of NEMO.Ubiquitination assay showed that NS5A induced the K27-linked but not the K48-linked polyubiquitination of NEMO for proteasomal degradation.In addition,NS5A blocked the K63-linked polyubiquitination of NEMO,thus inhibiting IKK phosphorylation,IκBαdegradation,and NF-κB activation.These findings revealed a novel mechanism by which CSFV inhibits host innate immunity,which might guide the drug design against CSFV in the future.展开更多
In the NEtwork MObility （NEMO） environment, mobile networks can form a nested structure. In nested mobile networks that use the NEMO Basic Support （NBS） protocol, pinball routing problems occur because packets are...In the NEtwork MObility （NEMO） environment, mobile networks can form a nested structure. In nested mobile networks that use the NEMO Basic Support （NBS） protocol, pinball routing problems occur because packets are routed to all the home agents of the mobile routers using nested tunneling. In addition, the nodes in the same mobile networks can communicate with each other regardless of Internet connectivity. However, the nodes in some mobile networks that are based on NBS cannot communicate when the network is disconnected from the Internet. In this paper, we propose a route optimization scheme to solve these problems. We introduce a new IPv6 routing header named ＂destination-information header＂ （DH）, which uses DH instead of routing header type 2 to optimize the route in the nested mobile network. The proposed scheme shows at least 30% better performance than ROTIO and similar performance improvement as DBU in inter-route optimization. With respect to intra-route optimization, the proposed scheme always uses the optimal routing path. In addition, the handover mechanism in ROAD＋ outperforms existing schemes and is less sensitive to network size than other existing schemes.展开更多
文摘以支持NBS协议(NEMO basic support protocol)的移动网络为研究对象,针对移动性管理和路由优化问题,提出基于改进HMIPv6的移动网络路由优化方案.将HMIPv6与NBS整合并构建层次化网络架构,利用HMIPv6的区域化管理机制降低移动网络内的移动节点注册开销.对HMIPv6进行改进,设计全新移动网络路由优化方案,消除移动网络内部节点通信过程中所存在的冗余路由.分析结果表明,同NBS对比,本方案在额外数据包开销和移动管理开销方面具有显著优势.
文摘代理移动IPv6是基于网络的移动性管理方案,其标准RFC5213中只规范了对单个节点的移动性支持,缺乏对子网移动的研究。研究了现有的3种代理移动IPv6下基于隧道的子网移动方案,重点分析了代理移动IPv6下采用隧道分离思想的移动子网实现方法 N-NEMO(network based NEMO),并在Linux环境下采用C语言对3种方案分别给予实现,对3种子网移动方案进行性能分析和对比,结果表明,虽然N-NEMO的切换时延较大且信令较为复杂,但是具有网络层头部开销小及支持节点类型全面的优点。
基金the National Nature Science Foundation of China(Grant No.31972677)the Construction Project of Liaoning Provincial Key Laboratory,China(2022JH13/10200026).
文摘The NS5A non-structural protein of classical swine fever virus(CSFV)is a multifunctional protein involved in viral genomic replication,protein translation,assembly of infectious virus particles,and regulation of cellular signaling pathways.Previous report showed that NS5A inhibited nuclear factor kappa B(NF-κB)signaling induced by poly(I:C);however,the mechanism involved has not been elucidated.Here,we reported that NS5A directly interacted with NF-κB essential modulator(NEMO),a regulatory subunit of the IκB kinase(IKK)complex,to inhibit the NF-κB signaling pathway.Further investigations showed that the zinc finger domain of NEMO and the aa 126–250 segment of NS5A are essential for the interaction between NEMO and NS5A.Mechanistic analysis revealed that NS5A mediated the proteasomal degradation of NEMO.Ubiquitination assay showed that NS5A induced the K27-linked but not the K48-linked polyubiquitination of NEMO for proteasomal degradation.In addition,NS5A blocked the K63-linked polyubiquitination of NEMO,thus inhibiting IKK phosphorylation,IκBαdegradation,and NF-κB activation.These findings revealed a novel mechanism by which CSFV inhibits host innate immunity,which might guide the drug design against CSFV in the future.
基金supported by MKE,Korea,under ITRC NIPA-2009-(C1090-0902-0046)by MEST,Korea under WCU Program supervised by the KOSEF(No.R31-2008-000-10062-0).
文摘In the NEtwork MObility （NEMO） environment, mobile networks can form a nested structure. In nested mobile networks that use the NEMO Basic Support （NBS） protocol, pinball routing problems occur because packets are routed to all the home agents of the mobile routers using nested tunneling. In addition, the nodes in the same mobile networks can communicate with each other regardless of Internet connectivity. However, the nodes in some mobile networks that are based on NBS cannot communicate when the network is disconnected from the Internet. In this paper, we propose a route optimization scheme to solve these problems. We introduce a new IPv6 routing header named ＂destination-information header＂ （DH）, which uses DH instead of routing header type 2 to optimize the route in the nested mobile network. The proposed scheme shows at least 30% better performance than ROTIO and similar performance improvement as DBU in inter-route optimization. With respect to intra-route optimization, the proposed scheme always uses the optimal routing path. In addition, the handover mechanism in ROAD＋ outperforms existing schemes and is less sensitive to network size than other existing schemes.
