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Effects of Cell Microtopology on the In-plane Dynamic Crushing Analysis of Re-entrant Square Cellular Material 被引量:7
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作者 Fangwu Ma Ying Zhao +1 位作者 Hongyu Liang Jiawei Wang 《Automotive Innovation》 EI 2018年第1期24-34,共11页
With the development of three-dimensional printing technologies, so-called cellular materials have achieved increasingattention due to outstanding properties. Unlike pure solid structures, properties of cellular mater... With the development of three-dimensional printing technologies, so-called cellular materials have achieved increasingattention due to outstanding properties. Unlike pure solid structures, properties of cellular materials are influenced by bothutilized material and cell microtopology. The present paper proposes a novel type of re-entrant square cellular material.To explore the relationship between microtopology and macrodynamic responses systematically, an explicit dynamic finiteelement simulation method is used. This work starts by constructing theoretical models of relative density employing atwo-dimensional unit cell. Then, the effects of geometric features and configurations on dynamic properties are explored,and simulations indicate that variations of geometric parameters strongly affect properties and that the staggered re-entrantsquares are more stable than the regular re-entrant squares. Subsequently, the effects of the impact velocity on dynamiccrushing behaviors are elaborated. On this basis, the relationship of unit mass energy absorption and geometric features isobtained by employing the response surface method. Furthermore, with targets of maximum unit mass energy absorption andminimum relative density, the optimal structural parameters are achieved by using non-dominated sorting genetic algorithm.The study provides a detailed introduction to dynamic behaviors of cellular materials and guidance to design new structureswith superior characteristics of energy absorption. 展开更多
关键词 Re-entrant cellular material Dynamic crushing microtopology IN-PLANE Finite element analysis
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IL-8刺激L-选择素水解断裂对细胞膜拓扑结构和刚度的影响 被引量:1
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作者 贾潇凌 王世骐 +1 位作者 陈娟 龙勉 《医用生物力学》 EI CAS CSCD 2009年第5期379-383,389,共6页
目的研究IL-8刺激所致的L-选择素水解断裂是否会引起细胞膜结构和刚度的变化,进而影响L-选择素-配体的反应动力学。方法分别用IL-8、TAPI-0+IL-8和TAPI-0处理本构表达L-选择素的Jurkat细胞,用以构建L-选择素水解断裂、阻断水解断裂和阻... 目的研究IL-8刺激所致的L-选择素水解断裂是否会引起细胞膜结构和刚度的变化,进而影响L-选择素-配体的反应动力学。方法分别用IL-8、TAPI-0+IL-8和TAPI-0处理本构表达L-选择素的Jurkat细胞,用以构建L-选择素水解断裂、阻断水解断裂和阻断剂对照的细胞-分子模型。采用扫描电镜观察其表面拓扑结构,采用微管吸吮方法测量其刚度。结果与正常组相比,水解断裂组和阻断水解断裂组细胞微绒毛减少、表面趋于光滑,而阻断剂对照组则无明显变化;无论是水解断裂组,阻断水解断裂组还是阻断剂对照组,细胞膜刚度与正常组相比均无显著性差异。结论IL-8刺激所致L-选择素水解断裂会引发细胞膜拓扑结构的变化,进而影响L-选择素-配体反应动力学的变化;而细胞膜刚度未见明显变化,表明载体刚度不是水解断裂引发L-选择素-配体反应动力学变化的因素。 展开更多
关键词 白细胞介素-8(IL-8) L-选择素水解断裂 拓扑结构 刚度 动力学
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