Nanoparticles have been widely utilized in biological research in recent years. 1,6-Hexanedithiol was used as the medium in this work to attach Au nanoparticles on thegold plates. We studied the immobilization and hyb...Nanoparticles have been widely utilized in biological research in recent years. 1,6-Hexanedithiol was used as the medium in this work to attach Au nanoparticles on thegold plates. We studied the immobilization and hybridization of DNA probes onto the resulted plates using the quartz crystal microbalance method. Approximately 3-5 times adsorption enhancement of HS-DNA on the plates was obtained under our experimental conditions. Using this DNA sensor, the sensitivity was promoted by approximately three times to 0.35μg/mL.展开更多
基金The work was supported by the National Natural Science Foundation of China (Grant Nos. 39990570 and 29733110).
文摘Nanoparticles have been widely utilized in biological research in recent years. 1,6-Hexanedithiol was used as the medium in this work to attach Au nanoparticles on thegold plates. We studied the immobilization and hybridization of DNA probes onto the resulted plates using the quartz crystal microbalance method. Approximately 3-5 times adsorption enhancement of HS-DNA on the plates was obtained under our experimental conditions. Using this DNA sensor, the sensitivity was promoted by approximately three times to 0.35μg/mL.
