BACKGROUND Hepatorenal syndrome(HRS)is a severe complication of cirrhosis with high mortality,which necessitates accurate clinical decision.However,studies on prognostic factors and scoring systems to predict overall ...BACKGROUND Hepatorenal syndrome(HRS)is a severe complication of cirrhosis with high mortality,which necessitates accurate clinical decision.However,studies on prognostic factors and scoring systems to predict overall survival of HRS are not enough.Meanwhile,a multicenter cohort study with a long span of time could be more convincing.AIM To develop a novel and effective prognostic model for patients with HRS and clarify new prognostic factors.METHODS We retrospectively enrolled 1667 patients from four hospitals,and 371 eligible patients were finally analyzed to develop and validate a novel prognostic model for patients with HRS.Characteristics were compared between survivors and non-survivors,and potential prognostic factors were selected according to the impact on 28-d mortality.Accuracy in predicting 28-d mortality was compared between the novel and other scoring systems,including Model for End-Stage Liver Disease(MELD),Chronic Liver Failure-Sequential Organ Failure Assessment(CLIF-SOFA),and Chinese Group on the Study of Severe Hepatitis BAcute-on-Chronic Liver Failure(COSSH-ACLF).RESULTS Five prognostic factors,comprised of gender,international normalized ratio,mean corpuscular hemoglobin concentration,neutrophil percentage,and stage,were integrated into a new score,GIMNS;stage is a binary variable defined by the number of failed organs.GIMNS was positively correlated with MELD,CLIFSOFA,and COSSH-ACLF.Additionally,it had better accuracy[area under the receiver operating characteristic curve(AUROC):0.830]than MELD(AUROC:0.759),CLIF-SOFA(AUROC:0.767),and COSSH-ACLF(AUROC:0.759)in the derivation cohort(P<0.05).It performed better than MELD and CLIF-SOFA in the validation cohort(P<0.050)and had a higher AUROC than COSSH-ACLF(P=0.122).CONCLUSION We have developed a new scoring system,GIMNS,to predict 28-d mortality of HRS patients.Mean corpuscular hemoglobin concentration and stage were first proposed and found to be related to the mortality of HRS.Additionally,the GIMNS score showed better accuracy than MELD and CL展开更多
The paper studies on the sediment-laden flow by using MicroADV.Laboratory calibration has been conducted to determine the relationship between backscattered signal strength and sediment concentration. Based on the exp...The paper studies on the sediment-laden flow by using MicroADV.Laboratory calibration has been conducted to determine the relationship between backscattered signal strength and sediment concentration. Based on the experimental data,the interactions between sediment and fluid in open channel flow are investi- gated.The experiment shows that there exist inner relation between sediment concentration and turbulence, and the relationship is distinctry related to the diameter of particle as well as the flow co...展开更多
Two simplified models, linear and nonlinear, were used in a cementation process on a homogeneous thin carbon steel plate. The parameters for these models, as obtained by the least squares’ method the first one in a g...Two simplified models, linear and nonlinear, were used in a cementation process on a homogeneous thin carbon steel plate. The parameters for these models, as obtained by the least squares’ method the first one in a global way while the other parameters refer to the second model—were estimated by a set of local minimums. To compare the performance of these models we used theoretical data, for the same diffusion problem obtained by a one-dimensional transient model considering the concentrations in the mean plane of the plate. The results for carbon concentrations in weight percentage in the plate (%pC) as a time-only dependent function with these simplified models to represent the analyzed diffusion process were in good agreement with those from a stricter model. The diffusion flows of these models were determined and a reasonable agreement can be seen in relation to the flow obtained by the theoretical model on the surface of the plate. This study shows that it is possible to use this methodology with the given restrictions adopted here to describe the concentration and the diffusion flow of other solutes in thin membranes.展开更多
Cui and Zhong(2019),(Computational Statistics&Data Analysis,139,117–133)proposed a test based on the mean variance(MV)index to test independence between a categorical random variable Y with R categories and a con...Cui and Zhong(2019),(Computational Statistics&Data Analysis,139,117–133)proposed a test based on the mean variance(MV)index to test independence between a categorical random variable Y with R categories and a continuous random variable X.They ingeniously proved the asymptotic normality of the MV test statistic when R diverges to infinity,which brings many merits to the MV test,including making it more convenient for independence testing when R is large.This paper considers a new test called the integral Pearson chi-square(IPC)test,whose test statistic can be viewed as a modified MV test statistic.A central limit theorem of the martin-gale difference is used to show that the asymptotic null distribution of the standardized IPC test statistic when R is diverging is also a normal distribution,rendering the IPC test sharing many merits with the MV test.As an application of such a theoretical finding,the IPC test is extended to test independence between continuous random variables.The finite sample performance of the proposed test is assessed by Monte Carlo simulations,and a real data example is presented for illustration.展开更多
Hydrological and hydro-chemical monitoring of nitrogen(N) and phosphorus(P) in a small urbanized catchment was conducted in the hilly area of the central Sichuan Basin,China,from 2010 through 2011.The diffuse N and P ...Hydrological and hydro-chemical monitoring of nitrogen(N) and phosphorus(P) in a small urbanized catchment was conducted in the hilly area of the central Sichuan Basin,China,from 2010 through 2011.The diffuse N and P loadings in different forms of total nitrogen(TN) and phosphorus(TP),dissolved nitrogen(DN) and phosphorus(DP),as well as particulate nitrogen(PN) and phosphorus(PP) were calculated based on runoff discharges and chemical analyses.The results revealed that the diffuse pollution concentrations of TN,DN,PN,TP,DP and PP exhibited large variations during rainfall events,with peak concentrations occurring during the initial period.For all of the measured parameters,the event mean concentrations(EMCs) were observed to clearly vary among rainfall events.The EMCs of TN,DN,PN,TP,DP and PP(for all of the observed rainfall events) were 10.04,6.62,3.42,1.30,0.47 and0.83 mg/L,respectively.The losses of diffuse N and P exhibited clear seasonal patterns and mainly occurred during the period from July through September,when the losses totaled 99.3 and 9.6 kg/ha for TN and TP,respectively,accounting for 75% and 74% of the total annual loadings.The mean annual loadings of TN and TP were 124.6 and 12.9 kg/ha,respectively.The results indicate that residential areas in the hilly areaof the central Sichuan Basin are subject to high diffuse N and P loadings,posing a serious risk to the receiving water quality.Ecological buffering belts are recommended to incorporate into the urbanized catchment to reduce diffuse pollution.展开更多
The objective of this study was to primarily investigate the effects of sand grains with different mean diameters and concentrations on cavitation flow development in a nozzle. One new solid-liquid-vapor three-phase c...The objective of this study was to primarily investigate the effects of sand grains with different mean diameters and concentrations on cavitation flow development in a nozzle. One new solid-liquid-vapor three-phase coupling numerical method was presented and a cavitation model was changed to perform numerical simulations. Results indicated that sand grain-pure water-cavitation flow(SG-PW-CF) vapor contents were greater than in pure water-cavitation flow(PW-CF). Sand grains were found to promote cavitation flow development, with the concentration promotion range becoming smaller with increased mean diameter. The mechanisms for these effects were explored and revealed as well. In SG-PW-CF, cavitation nuclei number was greater and tensile stress was also greater than in PW-CF. The maximum and absolute minimum slip velocities and maximum and minimum turbulent kinetic energies of SG-PW-CF were greater than in PW-CF. These effects on SG-PW-CF evolution were large, involving primary factors. The calculated magnitude of the Saffman lift force in SG-PW-CF was small(10^(-2)), with its effects relatively weak and it was thus a secondary factor. Effects of variations of flow fields were more significant than force changes. In SG-PW-CF, variations of a single parameter with the concentration could not reflect the alternating relationships of vapor content with the concentration. Indeed, it was a combination of variations of all parameters.展开更多
This paper presents a method of measuring the particle mean size and dust concentration by small angle near forward light scattering optics and the extinction theory. Its theory is based on Fraunhofer diffraction the...This paper presents a method of measuring the particle mean size and dust concentration by small angle near forward light scattering optics and the extinction theory. Its theory is based on Fraunhofer diffraction theory which is the approximation of Mie scattering within the forward Fraunhofer diffraction lobe, and Rosin Rammler function is introduced to describe the particle size distribution in two phase flow in advance. Compared with the values by the sample weight method, the measurement results have a reasonable agreement. The present work has demonstrated that this method will be probably used to monitor the parameters of two phase flow.展开更多
基金Chinese High Tech Research&Development(863)Program,No.2013AA020102.
文摘BACKGROUND Hepatorenal syndrome(HRS)is a severe complication of cirrhosis with high mortality,which necessitates accurate clinical decision.However,studies on prognostic factors and scoring systems to predict overall survival of HRS are not enough.Meanwhile,a multicenter cohort study with a long span of time could be more convincing.AIM To develop a novel and effective prognostic model for patients with HRS and clarify new prognostic factors.METHODS We retrospectively enrolled 1667 patients from four hospitals,and 371 eligible patients were finally analyzed to develop and validate a novel prognostic model for patients with HRS.Characteristics were compared between survivors and non-survivors,and potential prognostic factors were selected according to the impact on 28-d mortality.Accuracy in predicting 28-d mortality was compared between the novel and other scoring systems,including Model for End-Stage Liver Disease(MELD),Chronic Liver Failure-Sequential Organ Failure Assessment(CLIF-SOFA),and Chinese Group on the Study of Severe Hepatitis BAcute-on-Chronic Liver Failure(COSSH-ACLF).RESULTS Five prognostic factors,comprised of gender,international normalized ratio,mean corpuscular hemoglobin concentration,neutrophil percentage,and stage,were integrated into a new score,GIMNS;stage is a binary variable defined by the number of failed organs.GIMNS was positively correlated with MELD,CLIFSOFA,and COSSH-ACLF.Additionally,it had better accuracy[area under the receiver operating characteristic curve(AUROC):0.830]than MELD(AUROC:0.759),CLIF-SOFA(AUROC:0.767),and COSSH-ACLF(AUROC:0.759)in the derivation cohort(P<0.05).It performed better than MELD and CLIF-SOFA in the validation cohort(P<0.050)and had a higher AUROC than COSSH-ACLF(P=0.122).CONCLUSION We have developed a new scoring system,GIMNS,to predict 28-d mortality of HRS patients.Mean corpuscular hemoglobin concentration and stage were first proposed and found to be related to the mortality of HRS.Additionally,the GIMNS score showed better accuracy than MELD and CL
基金Supported by National Key Basic Research and Development Program(973 Program)(2003CB415205)the National Natural Science Foundation of China and the Research Fund for the Doctoral Program of Higher Education of the Ministry of Education of China
文摘The paper studies on the sediment-laden flow by using MicroADV.Laboratory calibration has been conducted to determine the relationship between backscattered signal strength and sediment concentration. Based on the experimental data,the interactions between sediment and fluid in open channel flow are investi- gated.The experiment shows that there exist inner relation between sediment concentration and turbulence, and the relationship is distinctry related to the diameter of particle as well as the flow co...
文摘Two simplified models, linear and nonlinear, were used in a cementation process on a homogeneous thin carbon steel plate. The parameters for these models, as obtained by the least squares’ method the first one in a global way while the other parameters refer to the second model—were estimated by a set of local minimums. To compare the performance of these models we used theoretical data, for the same diffusion problem obtained by a one-dimensional transient model considering the concentrations in the mean plane of the plate. The results for carbon concentrations in weight percentage in the plate (%pC) as a time-only dependent function with these simplified models to represent the analyzed diffusion process were in good agreement with those from a stricter model. The diffusion flows of these models were determined and a reasonable agreement can be seen in relation to the flow obtained by the theoretical model on the surface of the plate. This study shows that it is possible to use this methodology with the given restrictions adopted here to describe the concentration and the diffusion flow of other solutes in thin membranes.
基金National Natural Science Foundation of China[Grant numbers 12271286,11931001 and 11771241].
文摘Cui and Zhong(2019),(Computational Statistics&Data Analysis,139,117–133)proposed a test based on the mean variance(MV)index to test independence between a categorical random variable Y with R categories and a continuous random variable X.They ingeniously proved the asymptotic normality of the MV test statistic when R diverges to infinity,which brings many merits to the MV test,including making it more convenient for independence testing when R is large.This paper considers a new test called the integral Pearson chi-square(IPC)test,whose test statistic can be viewed as a modified MV test statistic.A central limit theorem of the martin-gale difference is used to show that the asymptotic null distribution of the standardized IPC test statistic when R is diverging is also a normal distribution,rendering the IPC test sharing many merits with the MV test.As an application of such a theoretical finding,the IPC test is extended to test independence between continuous random variables.The finite sample performance of the proposed test is assessed by Monte Carlo simulations,and a real data example is presented for illustration.
基金provided by the Innovative Team Program of Chinese Academy of Sciences (Grant No.KZZD-EW-TZ-06)the National Natural Science Foundation of China (Grant No.41430750)the National Science & Technology Pillar Program (Grant No.2011BAD31B03)
文摘Hydrological and hydro-chemical monitoring of nitrogen(N) and phosphorus(P) in a small urbanized catchment was conducted in the hilly area of the central Sichuan Basin,China,from 2010 through 2011.The diffuse N and P loadings in different forms of total nitrogen(TN) and phosphorus(TP),dissolved nitrogen(DN) and phosphorus(DP),as well as particulate nitrogen(PN) and phosphorus(PP) were calculated based on runoff discharges and chemical analyses.The results revealed that the diffuse pollution concentrations of TN,DN,PN,TP,DP and PP exhibited large variations during rainfall events,with peak concentrations occurring during the initial period.For all of the measured parameters,the event mean concentrations(EMCs) were observed to clearly vary among rainfall events.The EMCs of TN,DN,PN,TP,DP and PP(for all of the observed rainfall events) were 10.04,6.62,3.42,1.30,0.47 and0.83 mg/L,respectively.The losses of diffuse N and P exhibited clear seasonal patterns and mainly occurred during the period from July through September,when the losses totaled 99.3 and 9.6 kg/ha for TN and TP,respectively,accounting for 75% and 74% of the total annual loadings.The mean annual loadings of TN and TP were 124.6 and 12.9 kg/ha,respectively.The results indicate that residential areas in the hilly areaof the central Sichuan Basin are subject to high diffuse N and P loadings,posing a serious risk to the receiving water quality.Ecological buffering belts are recommended to incorporate into the urbanized catchment to reduce diffuse pollution.
基金financially supported by China Postdoctoral Science Foundation(2021MD703972)the National Key Research and Development Program of China(No.2018YFC0808400)+1 种基金National Natural Science Foundation of China(No.52074194)the National Key Basic Research Program of China(No.2014CB239203)。
文摘The objective of this study was to primarily investigate the effects of sand grains with different mean diameters and concentrations on cavitation flow development in a nozzle. One new solid-liquid-vapor three-phase coupling numerical method was presented and a cavitation model was changed to perform numerical simulations. Results indicated that sand grain-pure water-cavitation flow(SG-PW-CF) vapor contents were greater than in pure water-cavitation flow(PW-CF). Sand grains were found to promote cavitation flow development, with the concentration promotion range becoming smaller with increased mean diameter. The mechanisms for these effects were explored and revealed as well. In SG-PW-CF, cavitation nuclei number was greater and tensile stress was also greater than in PW-CF. The maximum and absolute minimum slip velocities and maximum and minimum turbulent kinetic energies of SG-PW-CF were greater than in PW-CF. These effects on SG-PW-CF evolution were large, involving primary factors. The calculated magnitude of the Saffman lift force in SG-PW-CF was small(10^(-2)), with its effects relatively weak and it was thus a secondary factor. Effects of variations of flow fields were more significant than force changes. In SG-PW-CF, variations of a single parameter with the concentration could not reflect the alternating relationships of vapor content with the concentration. Indeed, it was a combination of variations of all parameters.
文摘This paper presents a method of measuring the particle mean size and dust concentration by small angle near forward light scattering optics and the extinction theory. Its theory is based on Fraunhofer diffraction theory which is the approximation of Mie scattering within the forward Fraunhofer diffraction lobe, and Rosin Rammler function is introduced to describe the particle size distribution in two phase flow in advance. Compared with the values by the sample weight method, the measurement results have a reasonable agreement. The present work has demonstrated that this method will be probably used to monitor the parameters of two phase flow.
