背景与目的:卵巢成熟、未成熟畸胎瘤术前鉴别诊断较困难,本研究期望通过血清肿瘤标志物联合检测的方法,为其诊断及鉴别诊断提供有价值依据。方法:收集1995年1月至2005年12月在中山大学肿瘤防治中心初治并经病理确诊为单纯型卵巢畸胎瘤的...背景与目的:卵巢成熟、未成熟畸胎瘤术前鉴别诊断较困难,本研究期望通过血清肿瘤标志物联合检测的方法,为其诊断及鉴别诊断提供有价值依据。方法:收集1995年1月至2005年12月在中山大学肿瘤防治中心初治并经病理确诊为单纯型卵巢畸胎瘤的272例患者的临床资料,统计分析血清糖链抗原125(carbohydrate antigen125,CA125)、糖链抗原153(CA153)、糖链抗原199(CA199)、神经元特异性烯醇化酶(neuron specific enolase,NSE)、甲胎蛋白(alpha-fetoprotein,AFP)、癌胚抗原(carcinoembryonic antigen,CEA)的检测水平在卵巢成熟及未成熟畸胎瘤中的差异。结果:254例卵巢成熟畸胎瘤患者,中位年龄30岁,血清CA125、CA153、CA199、NSE、AFP、CEA平均值分别为25.5×103u/L,11.8×103u/L,106.6×103u/L,12.6μg/L,2.7μg/L和2.5μg/L。18例卵巢未成熟畸胎瘤患者,中位年龄23岁,上述6项指标的平均值分别为140.3×103u/L,16.8×103u/L,112.0×103u/L,18.0μg/L,369.5μg/L和3.2μg/L。未成熟畸胎瘤患者血清中CA125、CA153、AFP平均水平及表达阳性率均高于成熟畸胎瘤患者,差异有统计学意义(P<0.05)。单独应用一项指标,CA125、CA153、AFP对未成熟畸胎瘤诊断性能的特异度均较高,而CA125的灵敏度最高(50.0%)。使用CA125、CA153、AFP三项指标联合检测明显提高了灵敏度(71.4%)。结论:术前肿瘤标志物,尤其是CA125、CA153、AFP联合检测对卵巢未成熟型与成熟型畸胎瘤的鉴别诊断有一定参考价值。展开更多
A 32-year-old patient with no previous history was admitted for chest pain, dyspnea, <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-fami...A 32-year-old patient with no previous history was admitted for chest pain, dyspnea, <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">appetite and weight loss</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">.</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Chest X-ray revealed an</span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;"> opacity involving the lower two-thirds of the right hemithorax, suggestive of a pleural effusion. </span><span style="font-family:Verdana;">Because of the absence of fluid return even after ultrasound-guided </span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">thoracentesis,</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> a </span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">Chest Computed tomography was required showing a heterogeneous anterior mediastinal mass with soft tissue, fat, fluid and calcifications associated </span><span style="font-family:Verdana;">with extensive encysted fluid collection in the right hemithorax. A</span><span style="font-family:Verdana;"> video-assisted mini-thoracotomy revealed a mediastinal tumor firmly attached to the thy</span><span style="font-family:Verdana;">mus with a cystic wall lined by squamous epithelium and sebaceous gland</span><span style="font-family:Verdana;"> composed of respiratory tissue, adipose tissue, cartilage,</span></span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">smo展开更多
Introduction: The word “Teratoma” derives from the Greek word “teratos” including the meaning show. Teratoid tumors derived from the transformation of multipotent germ cells. They are composed of ectodermal, endod...Introduction: The word “Teratoma” derives from the Greek word “teratos” including the meaning show. Teratoid tumors derived from the transformation of multipotent germ cells. They are composed of ectodermal, endodermic and mesodermal tissues in variable proportions;hence the term “embryonic tumor”. Objectives: We are reporting the case of a mature teratoma discovered in a young child whose delivery was vaginally performed. Through this case we put in diagnostic and therapeutic highlight and we made a literature review. Case report: Patient 17 months admitted for the anterior compartment mass associated with inspiratory dyspnea. No anomaly/abnormality was detected during the follow-up of the pregnancy. The Patient with dyspnea grade 2 was admitted according to Chevaleir-Jackson classification. No abnormalities of stature ponderal developments were noted. Surgery of excision was our therapeutic alternative. Through the pathological examination a mature teratoma was found. Conclusion: Teratoma is a rare condition. Proper management of mature teratoma helps to prevent recurrence.展开更多
Introduction: teratomas are non-malignantgerm cell tumors commonly composed of cell types derived from all of the three germ layers. Intracerebral teratomas typically are midline or paraxial lesions located in the pit...Introduction: teratomas are non-malignantgerm cell tumors commonly composed of cell types derived from all of the three germ layers. Intracerebral teratomas typically are midline or paraxial lesions located in the pituitary stalk or the pineal region. We report our experience with mature teratomas of the posterior fossa. Case report: we present the case of an 11-year-old caucasian female with progressive headache that caused interrupted sleep. Cerebral magnetic resonance imaging showed a midline lesion in the posterior fossa with mass effect and without contrast enhancement. Anatomic pathology revealed a mature teratoma. Conclusion: differential diagnosis of midline lesions in pediatric patients must include teratomas in spite of being posterior fossa lesions.展开更多
文摘背景与目的:卵巢成熟、未成熟畸胎瘤术前鉴别诊断较困难,本研究期望通过血清肿瘤标志物联合检测的方法,为其诊断及鉴别诊断提供有价值依据。方法:收集1995年1月至2005年12月在中山大学肿瘤防治中心初治并经病理确诊为单纯型卵巢畸胎瘤的272例患者的临床资料,统计分析血清糖链抗原125(carbohydrate antigen125,CA125)、糖链抗原153(CA153)、糖链抗原199(CA199)、神经元特异性烯醇化酶(neuron specific enolase,NSE)、甲胎蛋白(alpha-fetoprotein,AFP)、癌胚抗原(carcinoembryonic antigen,CEA)的检测水平在卵巢成熟及未成熟畸胎瘤中的差异。结果:254例卵巢成熟畸胎瘤患者,中位年龄30岁,血清CA125、CA153、CA199、NSE、AFP、CEA平均值分别为25.5×103u/L,11.8×103u/L,106.6×103u/L,12.6μg/L,2.7μg/L和2.5μg/L。18例卵巢未成熟畸胎瘤患者,中位年龄23岁,上述6项指标的平均值分别为140.3×103u/L,16.8×103u/L,112.0×103u/L,18.0μg/L,369.5μg/L和3.2μg/L。未成熟畸胎瘤患者血清中CA125、CA153、AFP平均水平及表达阳性率均高于成熟畸胎瘤患者,差异有统计学意义(P<0.05)。单独应用一项指标,CA125、CA153、AFP对未成熟畸胎瘤诊断性能的特异度均较高,而CA125的灵敏度最高(50.0%)。使用CA125、CA153、AFP三项指标联合检测明显提高了灵敏度(71.4%)。结论:术前肿瘤标志物,尤其是CA125、CA153、AFP联合检测对卵巢未成熟型与成熟型畸胎瘤的鉴别诊断有一定参考价值。
文摘A 32-year-old patient with no previous history was admitted for chest pain, dyspnea, <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">appetite and weight loss</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">.</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Chest X-ray revealed an</span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;"> opacity involving the lower two-thirds of the right hemithorax, suggestive of a pleural effusion. </span><span style="font-family:Verdana;">Because of the absence of fluid return even after ultrasound-guided </span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">thoracentesis,</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> a </span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">Chest Computed tomography was required showing a heterogeneous anterior mediastinal mass with soft tissue, fat, fluid and calcifications associated </span><span style="font-family:Verdana;">with extensive encysted fluid collection in the right hemithorax. A</span><span style="font-family:Verdana;"> video-assisted mini-thoracotomy revealed a mediastinal tumor firmly attached to the thy</span><span style="font-family:Verdana;">mus with a cystic wall lined by squamous epithelium and sebaceous gland</span><span style="font-family:Verdana;"> composed of respiratory tissue, adipose tissue, cartilage,</span></span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">smo
文摘Introduction: The word “Teratoma” derives from the Greek word “teratos” including the meaning show. Teratoid tumors derived from the transformation of multipotent germ cells. They are composed of ectodermal, endodermic and mesodermal tissues in variable proportions;hence the term “embryonic tumor”. Objectives: We are reporting the case of a mature teratoma discovered in a young child whose delivery was vaginally performed. Through this case we put in diagnostic and therapeutic highlight and we made a literature review. Case report: Patient 17 months admitted for the anterior compartment mass associated with inspiratory dyspnea. No anomaly/abnormality was detected during the follow-up of the pregnancy. The Patient with dyspnea grade 2 was admitted according to Chevaleir-Jackson classification. No abnormalities of stature ponderal developments were noted. Surgery of excision was our therapeutic alternative. Through the pathological examination a mature teratoma was found. Conclusion: Teratoma is a rare condition. Proper management of mature teratoma helps to prevent recurrence.
文摘Introduction: teratomas are non-malignantgerm cell tumors commonly composed of cell types derived from all of the three germ layers. Intracerebral teratomas typically are midline or paraxial lesions located in the pituitary stalk or the pineal region. We report our experience with mature teratomas of the posterior fossa. Case report: we present the case of an 11-year-old caucasian female with progressive headache that caused interrupted sleep. Cerebral magnetic resonance imaging showed a midline lesion in the posterior fossa with mass effect and without contrast enhancement. Anatomic pathology revealed a mature teratoma. Conclusion: differential diagnosis of midline lesions in pediatric patients must include teratomas in spite of being posterior fossa lesions.
