智慧协同网络具有能够实时准确测算流量矩阵的特点。将流量矩阵作为约束,对负载均衡路由优化问题进行建模,利用拉格朗日对偶方法,将原问题转化为优化目标易实现的对偶问题。为实现对偶问题优化目标,提出一种基于流量矩阵的负载均衡路由(...智慧协同网络具有能够实时准确测算流量矩阵的特点。将流量矩阵作为约束,对负载均衡路由优化问题进行建模,利用拉格朗日对偶方法,将原问题转化为优化目标易实现的对偶问题。为实现对偶问题优化目标,提出一种基于流量矩阵的负载均衡路由(TM-LB,traffic matrix based load balancing)算法,供控制层根据实时网络情况为后续流规划传输路径。利用OMNET++仿真器在NFSnet拓扑结构上进行仿真实验,结果表明TM-LB相比传统路径规划机制能有效避免拥塞,实现负载均衡。最后,搭建原型系统对TM-LB算法的开销进行测试。展开更多
Treating articular cartilage defects in patients remains a challenging task due to the absence of blood vessels within the cartilage tissue.The regenerative potential is further compromised by an imbalance between ana...Treating articular cartilage defects in patients remains a challenging task due to the absence of blood vessels within the cartilage tissue.The regenerative potential is further compromised by an imbalance between anabolism and catabolism,induced by elevated levels of reactive oxygen species.However,the advent of tissue engineering introduces a promising strategy for cartilage regeneration,offering viable solutions such as mechanical support and controlled release of chondrogenic molecules or cytokines.In this study,we developed an antioxidant scaffold by incorporating natural silk fibroin(SF)and kartogenin(KGN)-loaded liposomes(SF-Lipo@KGN).The scaffold demonstrated appropriate pore size,connectivity,and water absorption and the sustained release of KGN was achieved through the encapsulation of liposomes.In vitro experiments revealed that the SF-Lipo@KGN scaffolds exhibited excellent biocompatibility,as evidenced by enhanced cell adhesion,migration,and proliferation of chondrocytes.The SF-Lipo@KGN scaffolds were found to stimulate cartilage matrix synthesis through the activation of the nuclear factor erythroid-2-related factor 2/heme oxygenase-1 antioxidant signaling pathway.In vivo experiments demonstrated the effective promotion of articular cartilage regeneration by the SF-Lipo@KGN scaffolds,which enhanced extracellular matrix anabolism and restored the intrinsic redox homeostasis.Overall,this study successfully developed biomimetic KGN-loaded scaffolds that restore cartilage redox homeostasis,indicating promising prospects for cartilage tissue engineering.展开更多
The matrix crack evolution of cross-ply ceramic matrix composites under uniaxial tensile loading is investigated using the energy balance method.Under tensile loading,the cross-ply ceramic matrix composites have five ...The matrix crack evolution of cross-ply ceramic matrix composites under uniaxial tensile loading is investigated using the energy balance method.Under tensile loading,the cross-ply ceramic matrix composites have five damage modes.The cracking mode 3 contains transverse cracking,matrix cracking and fiber/matrix interface debonding.The cracking mode 5 only contains matrix cracking and fiber/matrix interface debonding.The cracking stress of modes 3 and 5 appearing between existing transverse cracks is determined.And the multiple matrix crack evolution of mode 3 is determined.The effects of ply thickness,fiber volume fraction,interface shear stress and interface debonding energy on the cracking stress and matrix crack evolution are analyzed.Results indicate that the cracking mode 3 is more likely to appear between transverse cracks for the SiC/CAS material.展开更多
文摘智慧协同网络具有能够实时准确测算流量矩阵的特点。将流量矩阵作为约束,对负载均衡路由优化问题进行建模,利用拉格朗日对偶方法,将原问题转化为优化目标易实现的对偶问题。为实现对偶问题优化目标,提出一种基于流量矩阵的负载均衡路由(TM-LB,traffic matrix based load balancing)算法,供控制层根据实时网络情况为后续流规划传输路径。利用OMNET++仿真器在NFSnet拓扑结构上进行仿真实验,结果表明TM-LB相比传统路径规划机制能有效避免拥塞,实现负载均衡。最后,搭建原型系统对TM-LB算法的开销进行测试。
基金supported by the Natural Science Foundation of Jiangsu Province(BK20220046)the National Natural Science Foundation of China(82272494,82072442)+2 种基金the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX21_2971)Key Laboratory of Orthopaedics of Suzhou(SZS2022017)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
文摘Treating articular cartilage defects in patients remains a challenging task due to the absence of blood vessels within the cartilage tissue.The regenerative potential is further compromised by an imbalance between anabolism and catabolism,induced by elevated levels of reactive oxygen species.However,the advent of tissue engineering introduces a promising strategy for cartilage regeneration,offering viable solutions such as mechanical support and controlled release of chondrogenic molecules or cytokines.In this study,we developed an antioxidant scaffold by incorporating natural silk fibroin(SF)and kartogenin(KGN)-loaded liposomes(SF-Lipo@KGN).The scaffold demonstrated appropriate pore size,connectivity,and water absorption and the sustained release of KGN was achieved through the encapsulation of liposomes.In vitro experiments revealed that the SF-Lipo@KGN scaffolds exhibited excellent biocompatibility,as evidenced by enhanced cell adhesion,migration,and proliferation of chondrocytes.The SF-Lipo@KGN scaffolds were found to stimulate cartilage matrix synthesis through the activation of the nuclear factor erythroid-2-related factor 2/heme oxygenase-1 antioxidant signaling pathway.In vivo experiments demonstrated the effective promotion of articular cartilage regeneration by the SF-Lipo@KGN scaffolds,which enhanced extracellular matrix anabolism and restored the intrinsic redox homeostasis.Overall,this study successfully developed biomimetic KGN-loaded scaffolds that restore cartilage redox homeostasis,indicating promising prospects for cartilage tissue engineering.
基金Supported by the Graduate Innovation Foundation of Jiangsu Province(CX08B-133Z)the Doctoral Innovation Foundation of Nanjing University of Aeronautics and Astronautics(BCXJ08-05)~~
文摘The matrix crack evolution of cross-ply ceramic matrix composites under uniaxial tensile loading is investigated using the energy balance method.Under tensile loading,the cross-ply ceramic matrix composites have five damage modes.The cracking mode 3 contains transverse cracking,matrix cracking and fiber/matrix interface debonding.The cracking mode 5 only contains matrix cracking and fiber/matrix interface debonding.The cracking stress of modes 3 and 5 appearing between existing transverse cracks is determined.And the multiple matrix crack evolution of mode 3 is determined.The effects of ply thickness,fiber volume fraction,interface shear stress and interface debonding energy on the cracking stress and matrix crack evolution are analyzed.Results indicate that the cracking mode 3 is more likely to appear between transverse cracks for the SiC/CAS material.
