This study was to describe the use of inverted-L osteotomy of ramus and lilac bone graft for the management of mandibular deficiency in adult patients. From 2008 to 2010, 11 patients （aged 19 to 29 years） with mandi...This study was to describe the use of inverted-L osteotomy of ramus and lilac bone graft for the management of mandibular deficiency in adult patients. From 2008 to 2010, 11 patients （aged 19 to 29 years） with mandibular deficiency underwent intraoral or extraoral inverted-L osteotomy of ramus and lilac crest bone grafting. Data were collected from the patients＇ records, photographs and radiographs. The height and width of the ramus were successfully expanded by inverted-L osteotomy and lilac crest bone grafting with minimal complications in all patients, resulting in significant improvement in occlusion and facial appearance. Our early results showed that the inverted-L osteotomy of ramus and lilac crest bone grafting is safe and effective, and should be considered as a good alternative for the patients with mandibular deficiency.展开更多
Mandibular defect becomes a prevalent maxillofacial disease resulting in mandibular dysfunctions and huge psychological burdens to the patients.Considering the routine presence of oral contaminations and aesthetic res...Mandibular defect becomes a prevalent maxillofacial disease resulting in mandibular dysfunctions and huge psychological burdens to the patients.Considering the routine presence of oral contaminations and aesthetic restoration of facial structures,the current clinical treatments are however limited,incapable to reconstruct the structural integrity and regeneration,spurring the need for cost-effective mandibular tissue engineering.Hydrogel systems possess great merit for mandibular reconstruction with precise involvement of cells and bioactive factors.In this review,current clinical treatments and distinct mode(s)of mandible formation and pathological resorption are summarized,followed by a review of hydrogel-related mandibular tissue engineering,and an update on the advanced fabrication of hydrogels with improved mechanical property,antibacterial ability,injectable form,and 3D bioprinted hydrogel constructs.The exploration of advanced hydrogel systems will lay down a solid foundation for a bright future with more biocompatible,effective,and personalized treatment in mandibular reconstruction.展开更多
文摘This study was to describe the use of inverted-L osteotomy of ramus and lilac bone graft for the management of mandibular deficiency in adult patients. From 2008 to 2010, 11 patients （aged 19 to 29 years） with mandibular deficiency underwent intraoral or extraoral inverted-L osteotomy of ramus and lilac crest bone grafting. Data were collected from the patients＇ records, photographs and radiographs. The height and width of the ramus were successfully expanded by inverted-L osteotomy and lilac crest bone grafting with minimal complications in all patients, resulting in significant improvement in occlusion and facial appearance. Our early results showed that the inverted-L osteotomy of ramus and lilac crest bone grafting is safe and effective, and should be considered as a good alternative for the patients with mandibular deficiency.
基金Areas of Excellence Scheme(AoE/M402/20)Theme-based Research Scheme(T13-402/17 N)under the Research Grant Council of Hong Kong,Mainland-Hong Kong Joint Funding Scheme(MHP/030/20)+4 种基金National Natural Science Foundation of China(81802152 and 32171332)Natural Science Foundation of Guangdong Province(2019A1515012224)Research Grants Council Collaborative Research Fund(C4026-17WF)General Research Fund(14121918 and 14173917)Innovation and Technology Commission Funding(Ref No.ITS/208/18FX).
文摘Mandibular defect becomes a prevalent maxillofacial disease resulting in mandibular dysfunctions and huge psychological burdens to the patients.Considering the routine presence of oral contaminations and aesthetic restoration of facial structures,the current clinical treatments are however limited,incapable to reconstruct the structural integrity and regeneration,spurring the need for cost-effective mandibular tissue engineering.Hydrogel systems possess great merit for mandibular reconstruction with precise involvement of cells and bioactive factors.In this review,current clinical treatments and distinct mode(s)of mandible formation and pathological resorption are summarized,followed by a review of hydrogel-related mandibular tissue engineering,and an update on the advanced fabrication of hydrogels with improved mechanical property,antibacterial ability,injectable form,and 3D bioprinted hydrogel constructs.The exploration of advanced hydrogel systems will lay down a solid foundation for a bright future with more biocompatible,effective,and personalized treatment in mandibular reconstruction.
