Objective:To investigate resistance and safety of HHPG-19K in treating non-small cell lung cancer patients.Methods:A total of 30 cases were selected and randomly divided into 5 groups:three HHPG-19K groups of differen...Objective:To investigate resistance and safety of HHPG-19K in treating non-small cell lung cancer patients.Methods:A total of 30 cases were selected and randomly divided into 5 groups:three HHPG-19K groups of different dosage(60 μg/kg/day,100 μ g/kg/day,200 μ g/ kg/day),positive control group(Filgrastim,namely G-CSF5 μ g/kg/day) and negative control group.Safety indexes of 5 groups were observed and compared.Results:All patients had adverse event(100%) in three HHPG-19K groups,and increased ALP,ALT and AST were main events.The degree was mild to moderate.There was no significant difference in the incidence of adverse event between dosage groups and positive control group no difference.But the incidence of negative control group was 13%,which was significantly lower than dosage groups and positive control group.Conclusions:Non-small cell lung cancer patients have satisfactory tolerance to HHPG-19K,and have no resistance.Besides,dosage at 100 μ g/kg is the most safe.展开更多
In this paper, we discuss a mathematical model of malaria transmission between vector and host population. We study the basic qualitative properties of the model, the boundedness and non-negativity, calculate all equi...In this paper, we discuss a mathematical model of malaria transmission between vector and host population. We study the basic qualitative properties of the model, the boundedness and non-negativity, calculate all equilibria, and prove the global stability of them and the behaviour of the model when the basic reproduction ratio R0 is greater than one or less than one. The global stability of equilibria is established by using Lyapunov method. Graphical representations of the calculated parameters and their effects on disease eradication are provided.展开更多
Mosquito-borne diseases present a significant threat to human health,with the possibility of outbreaks of new mosquito-borne diseases always looming.Unfortunately,current measures to combat these diseases such as vacc...Mosquito-borne diseases present a significant threat to human health,with the possibility of outbreaks of new mosquito-borne diseases always looming.Unfortunately,current measures to combat these diseases such as vaccines and drugs are often either unavailable or ineffective.However,recent studies on microbiomes may reveal promising strategies to fight these diseases.In this review,we examine recent advances in our understanding of the effects of both the mosquito and vertebrate microbiomes on mosquito-borne diseases.We argue that the mosquito microbiome can have direct and indirect impacts on the transmission of these diseases,with mosquito symbiotic microorganisms,particularly Wolbachia bacteria,showing potential for controlling mosquito-borne diseases.Moreover,the skin microbiome of vertebrates plays a significant role in mosquito preferences,while the gut microbiome has an impact on the progression of mosquito-borne diseases in humans.As researchers continue to explore the role of microbiomes in mosquito-borne diseases,we highlight some promising future directions for this field.Ultimately,a better understanding of the interplay between mosquitoes,their hosts,pathogens,and the microbiomes of mosquitoes and hosts may hold the key to preventing and controlling mosquito-borne diseases.展开更多
Background:A key issue in achieving and sustaining malaria elimination is the need to prevent local transmission arising from imported cases of malaria.The likelihood of this occurring depends on a range of local faao...Background:A key issue in achieving and sustaining malaria elimination is the need to prevent local transmission arising from imported cases of malaria.The likelihood of this occurring depends on a range of local faaors,and these can be used to allocate resources to contain transmission.Therefore,a risk assessment and management strategy is required to identify risk indexes for malaria transmission when imported cases occur.These risks also need to be quantified and combined to give a weighted risk index score.This can then be used to allocate the resources to each administrative region to prevent transmission according to the degree of risk.Methods:A list of potential risk indexes were generated from a literature review,expert consultation and panel discussion.These were initially classified into 4 first-level indexes including infection source,transmitting conditions,population vulnerability and control capacity.Each of these was then expanded into more detailed second-level indexes.The Delphi method was then used to obtain expert opinion to review and revise these risk indexes over two consecutive rounds to quantify agreement among experts as to their level of importance.Risk indexes were included in the final Transmission Risk Framework if they achieved a weighted importance score≥4.The Analytic Hierarchy Process was then used to calculate the weight allocated to each of the final risk indexes.This was then used to create an assessment framework that can be used to evaluate local transmission risk in different areas.Results:Two rounds of Delphi consultation were conducted.Twenty-three experts were used at each round with 100%recovery rate of participant questionnaires.The coordination coefficients(W)for the two rounds of Delphi consultation were 0.341 and 0.423,respectively(P<0.05).Three first-level indexes and 13 second-level indexes were identified.The Analytic Hierarchy Process was performed to calculate the weight of the indexes.For the first-level indexes,infection source,transmitting conditions,and co展开更多
文摘Objective:To investigate resistance and safety of HHPG-19K in treating non-small cell lung cancer patients.Methods:A total of 30 cases were selected and randomly divided into 5 groups:three HHPG-19K groups of different dosage(60 μg/kg/day,100 μ g/kg/day,200 μ g/ kg/day),positive control group(Filgrastim,namely G-CSF5 μ g/kg/day) and negative control group.Safety indexes of 5 groups were observed and compared.Results:All patients had adverse event(100%) in three HHPG-19K groups,and increased ALP,ALT and AST were main events.The degree was mild to moderate.There was no significant difference in the incidence of adverse event between dosage groups and positive control group no difference.But the incidence of negative control group was 13%,which was significantly lower than dosage groups and positive control group.Conclusions:Non-small cell lung cancer patients have satisfactory tolerance to HHPG-19K,and have no resistance.Besides,dosage at 100 μ g/kg is the most safe.
文摘In this paper, we discuss a mathematical model of malaria transmission between vector and host population. We study the basic qualitative properties of the model, the boundedness and non-negativity, calculate all equilibria, and prove the global stability of them and the behaviour of the model when the basic reproduction ratio R0 is greater than one or less than one. The global stability of equilibria is established by using Lyapunov method. Graphical representations of the calculated parameters and their effects on disease eradication are provided.
基金This work was funded by the grants from the National Key R&D Program of China(Nos.2021YFC2300200,2018YFA0507202,2020YFC1200104,2021YFC2302405,2022YFC2303200,and 2022YFC2303400)National Natural Science Foundation of China(Nos.32188101,31825001,and 81961160737),Yunnan Chenggong expert workstation(Nos.202005AF150034)+2 种基金Innovation Team Project of Yunnan Science and Technology Department(Nos.202105AE160020)Tsinghua-Foshan Innovation Special Fund(TFISF)(Nos.2022THFS6124)Shenzhen San-Ming Project for prevention and research on vector-borne diseases.
文摘Mosquito-borne diseases present a significant threat to human health,with the possibility of outbreaks of new mosquito-borne diseases always looming.Unfortunately,current measures to combat these diseases such as vaccines and drugs are often either unavailable or ineffective.However,recent studies on microbiomes may reveal promising strategies to fight these diseases.In this review,we examine recent advances in our understanding of the effects of both the mosquito and vertebrate microbiomes on mosquito-borne diseases.We argue that the mosquito microbiome can have direct and indirect impacts on the transmission of these diseases,with mosquito symbiotic microorganisms,particularly Wolbachia bacteria,showing potential for controlling mosquito-borne diseases.Moreover,the skin microbiome of vertebrates plays a significant role in mosquito preferences,while the gut microbiome has an impact on the progression of mosquito-borne diseases in humans.As researchers continue to explore the role of microbiomes in mosquito-borne diseases,we highlight some promising future directions for this field.Ultimately,a better understanding of the interplay between mosquitoes,their hosts,pathogens,and the microbiomes of mosquitoes and hosts may hold the key to preventing and controlling mosquito-borne diseases.
基金This study was supported by the National Key Research and Development Program of China(No.2016YFC1200500)the Fourth Round of Three-Year Public Health Action Plan of Shanghai,China(No.15GWZK0101)the Science and Technology Plan of Health and Family Planning Commission of Jiangxi Province(No.20172002).
文摘Background:A key issue in achieving and sustaining malaria elimination is the need to prevent local transmission arising from imported cases of malaria.The likelihood of this occurring depends on a range of local faaors,and these can be used to allocate resources to contain transmission.Therefore,a risk assessment and management strategy is required to identify risk indexes for malaria transmission when imported cases occur.These risks also need to be quantified and combined to give a weighted risk index score.This can then be used to allocate the resources to each administrative region to prevent transmission according to the degree of risk.Methods:A list of potential risk indexes were generated from a literature review,expert consultation and panel discussion.These were initially classified into 4 first-level indexes including infection source,transmitting conditions,population vulnerability and control capacity.Each of these was then expanded into more detailed second-level indexes.The Delphi method was then used to obtain expert opinion to review and revise these risk indexes over two consecutive rounds to quantify agreement among experts as to their level of importance.Risk indexes were included in the final Transmission Risk Framework if they achieved a weighted importance score≥4.The Analytic Hierarchy Process was then used to calculate the weight allocated to each of the final risk indexes.This was then used to create an assessment framework that can be used to evaluate local transmission risk in different areas.Results:Two rounds of Delphi consultation were conducted.Twenty-three experts were used at each round with 100%recovery rate of participant questionnaires.The coordination coefficients(W)for the two rounds of Delphi consultation were 0.341 and 0.423,respectively(P<0.05).Three first-level indexes and 13 second-level indexes were identified.The Analytic Hierarchy Process was performed to calculate the weight of the indexes.For the first-level indexes,infection source,transmitting conditions,and co
