Advantages of breeding schemes using genetic marker information and/or multiple ovulation and embryo transfer(MOET) technology over the traditional approach were extensively evaluated through simulation.Milk yield was...Advantages of breeding schemes using genetic marker information and/or multiple ovulation and embryo transfer(MOET) technology over the traditional approach were extensively evaluated through simulation.Milk yield was the trait of interest and QTL was the genetic marker utilized.Eight dairy cattle breeding scenarios were considered,i.e.,traditional progeny testing breeding scheme(denoted as STANPT),GASPT scheme including a pre-selection of young bulls entering progeny testing based on their own QTL information,MOETPT scheme using MOET technology to generate young bulls and a selection of young bulls limited within the full-sib family,GAMOPT scheme adopting both QTL pre-selection and MOET technology,COMBPT scheme using a mixed linear model which considered QTL genotype instead of the BLUP model in GAMOPT,and three non-progeny testing schemes,i.e.the MOET,GAMO and COMB schemes,corresponding to MOETPT,GAMOPT and COMBPT with progeny testing being part of the system.Animals were selected based on their breeding value which was estimated under an animal model framework.Sequential selection over 17 years was performed in the simulations and 30 replicates were designed for each scenario.The influences of using QTL information and MOET technology on favorable QTL allele frequency,true breeding values,polygenetic breeding values and the accumulated genetic superiority were extensively evaluated,for five different populations including active sires,lactating cows,bull dams,bull sires,and young bulls.The results showed that the combined schemes significantly outperformed other approaches wherein accumulated true breeding value progressed.The difference between schemes exclusively using QTL information or MOET technology was not significant.The STANPT scheme was the least efficient among the 8 schemes.The schemes using MOET technology had a higher polygenetic response than others in the 17th year.The increases of frequency of the favorable QTL allele varied more greatly across the 3 male groups than in the lactating cows grou展开更多
萨福克肉羊是世界上公认的、优良的杂交改良父本,国内各地陆续引进了种羊或胚胎。亟待MOET(Multiply Ovulation and Embryo Transfer,MOET)技术开展纯种扩繁或种羊培育,而影响MOET技术环节的因素较多,包括超排药物筛选、剂量、超排程序...萨福克肉羊是世界上公认的、优良的杂交改良父本,国内各地陆续引进了种羊或胚胎。亟待MOET(Multiply Ovulation and Embryo Transfer,MOET)技术开展纯种扩繁或种羊培育,而影响MOET技术环节的因素较多,包括超排药物筛选、剂量、超排程序、超排次数、季节、供体输精方式、受体同期发情和受胎率等。本试验研究结果表明:FSH药物对获得胚胎数方面无明显差异(P<0.05),且国产FSH价格更便宜,每枚胚胎的成本较进口FSH有较大优势;在供体超排效率和获得可用胚胎数、受体移植成功率等方面差异不明显(P<0.05);在供体输精方式比较上,采用腹腔镜输精技术的供体获得可用胚胎数、卵子受精率和胚胎质量方面与传统方法比较差异极显著(P<0.01)。说明FSH药物筛选、超排程序、输精方式和受体移植等几个方面影响MOET效率,为MOET技术在生产中的应用提供技术依据。展开更多
年轻有为的设计天才
Thomas Tait这个名字，现在在时尚界可谓是拥有着响亮的名号，这位来自英国的新锐设计师荣获了由全球最大的精品集团LVMH（Louis Vuitton Moet Hennessy）所举办的首届LVMH新生代设计师大奖冠军（LVMH Young Fashio...年轻有为的设计天才
Thomas Tait这个名字，现在在时尚界可谓是拥有着响亮的名号，这位来自英国的新锐设计师荣获了由全球最大的精品集团LVMH（Louis Vuitton Moet Hennessy）所举办的首届LVMH新生代设计师大奖冠军（LVMH Young Fashion Designer Prize）。展开更多
基金Supported by Key Project for Introducing Advanced International Agriculture Science&Technologies (Grant No.2006-G48)the National Key Basic Research and Development Program of China (Grant No.2006CB102107)National Key Technology Research and Development Program of China (Grant No.2006BAD04A01)
文摘Advantages of breeding schemes using genetic marker information and/or multiple ovulation and embryo transfer(MOET) technology over the traditional approach were extensively evaluated through simulation.Milk yield was the trait of interest and QTL was the genetic marker utilized.Eight dairy cattle breeding scenarios were considered,i.e.,traditional progeny testing breeding scheme(denoted as STANPT),GASPT scheme including a pre-selection of young bulls entering progeny testing based on their own QTL information,MOETPT scheme using MOET technology to generate young bulls and a selection of young bulls limited within the full-sib family,GAMOPT scheme adopting both QTL pre-selection and MOET technology,COMBPT scheme using a mixed linear model which considered QTL genotype instead of the BLUP model in GAMOPT,and three non-progeny testing schemes,i.e.the MOET,GAMO and COMB schemes,corresponding to MOETPT,GAMOPT and COMBPT with progeny testing being part of the system.Animals were selected based on their breeding value which was estimated under an animal model framework.Sequential selection over 17 years was performed in the simulations and 30 replicates were designed for each scenario.The influences of using QTL information and MOET technology on favorable QTL allele frequency,true breeding values,polygenetic breeding values and the accumulated genetic superiority were extensively evaluated,for five different populations including active sires,lactating cows,bull dams,bull sires,and young bulls.The results showed that the combined schemes significantly outperformed other approaches wherein accumulated true breeding value progressed.The difference between schemes exclusively using QTL information or MOET technology was not significant.The STANPT scheme was the least efficient among the 8 schemes.The schemes using MOET technology had a higher polygenetic response than others in the 17th year.The increases of frequency of the favorable QTL allele varied more greatly across the 3 male groups than in the lactating cows grou
文摘萨福克肉羊是世界上公认的、优良的杂交改良父本,国内各地陆续引进了种羊或胚胎。亟待MOET(Multiply Ovulation and Embryo Transfer,MOET)技术开展纯种扩繁或种羊培育,而影响MOET技术环节的因素较多,包括超排药物筛选、剂量、超排程序、超排次数、季节、供体输精方式、受体同期发情和受胎率等。本试验研究结果表明:FSH药物对获得胚胎数方面无明显差异(P<0.05),且国产FSH价格更便宜,每枚胚胎的成本较进口FSH有较大优势;在供体超排效率和获得可用胚胎数、受体移植成功率等方面差异不明显(P<0.05);在供体输精方式比较上,采用腹腔镜输精技术的供体获得可用胚胎数、卵子受精率和胚胎质量方面与传统方法比较差异极显著(P<0.01)。说明FSH药物筛选、超排程序、输精方式和受体移植等几个方面影响MOET效率,为MOET技术在生产中的应用提供技术依据。
文摘年轻有为的设计天才
Thomas Tait这个名字，现在在时尚界可谓是拥有着响亮的名号，这位来自英国的新锐设计师荣获了由全球最大的精品集团LVMH（Louis Vuitton Moet Hennessy）所举办的首届LVMH新生代设计师大奖冠军（LVMH Young Fashion Designer Prize）。
