Recent seismic studies reveal a sharp velocity drop mostly at^70–100 km depth within the thick mantle keel beneath cratons, termed the mid-lithosphere discontinuity(MLD). The common presence of the MLD in cratonic re...Recent seismic studies reveal a sharp velocity drop mostly at^70–100 km depth within the thick mantle keel beneath cratons, termed the mid-lithosphere discontinuity(MLD). The common presence of the MLD in cratonic regions indicates structural and property layering of the subcontinental lithospheric mantle(SCLM). The nature and origin of the MLD, and many issues associated with the layering of the SCLM are essential to understand the formation and evolution of continents, and have become frontier subjects in the Earth sciences.展开更多
To evaluate the potentiality of applying gene therapy to endotoxemia in high-risk patients, we investigated the effects of transferring an adeno-associated virus serotype 2 （AAV2）-mediated BPI-Fcγ1 gene on protecti...To evaluate the potentiality of applying gene therapy to endotoxemia in high-risk patients, we investigated the effects of transferring an adeno-associated virus serotype 2 （AAV2）-mediated BPI-Fcγ1 gene on protecting mice from challenge of lethal endotoxin. The chimeric BPI-Fcγ1 gene consists of two parts, one encods functional N-terminus （1 to 199 amino acidic residues） of human BPI, which is a bactericidal/permeability-increasing protein, and the other encodes Fc segment of human immunoglobulin G1 （Fcγ1）. Our results indicated that the target protein could be expressed and secreted into the serum of the gene-transferred mice. After lethal endotoxin challenge, the levels of endotoxin and TNF-a in the gene-transferred mice were decreased. The survival rate of the BPI-Fcγ1 gene-transferred mice was markedly increased. Our data suggest that AAV2-mediated chimeric BPI-Fcγ1 gene delivery can potentially be used clinically for the protection and treatment of endotoxemia and endotoxic shock in high-risk individuals. Cellular ＆ Molecular Immunology. 2006;3（3）：221-225.展开更多
Nowadays, more and more attention is paid to the Mobile Ad hoc Network(MANET) because of its flexibility. To provide Internet access for MANET, the interworking mechanismbetween MANET and IP based fixed network is nee...Nowadays, more and more attention is paid to the Mobile Ad hoc Network(MANET) because of its flexibility. To provide Internet access for MANET, the interworking mechanismbetween MANET and IP based fixed network is needed, which has become a vivid research area.However, so far, little work has been done to connect the multicast protocols on both sides so thatusers can access multicast services on either side. In this paper, a so-called Modified MLD (M. MLD)is proposed as a solution to IPv6 multicast interworking between MANET and fixed networks.展开更多
基金supported by the National Natural Science Foundation of China (41225016, 41688103, 91414301)Chinese Academy of Sciences
文摘Recent seismic studies reveal a sharp velocity drop mostly at^70–100 km depth within the thick mantle keel beneath cratons, termed the mid-lithosphere discontinuity(MLD). The common presence of the MLD in cratonic regions indicates structural and property layering of the subcontinental lithospheric mantle(SCLM). The nature and origin of the MLD, and many issues associated with the layering of the SCLM are essential to understand the formation and evolution of continents, and have become frontier subjects in the Earth sciences.
文摘To evaluate the potentiality of applying gene therapy to endotoxemia in high-risk patients, we investigated the effects of transferring an adeno-associated virus serotype 2 （AAV2）-mediated BPI-Fcγ1 gene on protecting mice from challenge of lethal endotoxin. The chimeric BPI-Fcγ1 gene consists of two parts, one encods functional N-terminus （1 to 199 amino acidic residues） of human BPI, which is a bactericidal/permeability-increasing protein, and the other encodes Fc segment of human immunoglobulin G1 （Fcγ1）. Our results indicated that the target protein could be expressed and secreted into the serum of the gene-transferred mice. After lethal endotoxin challenge, the levels of endotoxin and TNF-a in the gene-transferred mice were decreased. The survival rate of the BPI-Fcγ1 gene-transferred mice was markedly increased. Our data suggest that AAV2-mediated chimeric BPI-Fcγ1 gene delivery can potentially be used clinically for the protection and treatment of endotoxemia and endotoxic shock in high-risk individuals. Cellular ＆ Molecular Immunology. 2006;3（3）：221-225.
文摘Nowadays, more and more attention is paid to the Mobile Ad hoc Network(MANET) because of its flexibility. To provide Internet access for MANET, the interworking mechanismbetween MANET and IP based fixed network is needed, which has become a vivid research area.However, so far, little work has been done to connect the multicast protocols on both sides so thatusers can access multicast services on either side. In this paper, a so-called Modified MLD (M. MLD)is proposed as a solution to IPv6 multicast interworking between MANET and fixed networks.
