移动数据具有数量庞大、类型多样、时效性强和高价值等特点.移动通信数据是一种重要的移动数据,对高效地存储和访问移动通信数据进行研究,并在此基础上更加有效地开展移动数据挖掘的相关研究,具有重大现实意义.当前,使用并行数据挖掘技...移动数据具有数量庞大、类型多样、时效性强和高价值等特点.移动通信数据是一种重要的移动数据,对高效地存储和访问移动通信数据进行研究,并在此基础上更加有效地开展移动数据挖掘的相关研究,具有重大现实意义.当前,使用并行数据挖掘技术进行数据挖掘得到普遍认可,但并行数据挖掘技术需要较高的硬件成本,并行算法代码调试和优化较为困难.为此提出大规模移动通信数据的单机实现MCDS(mobile communication data processing system).MCDS基于GraphChi,改进了数据格式、分片机制、数据分片换入换出机制.实验结果验证了MCDS的有效性,为移动数据挖掘提供了切实可行的实验环境.展开更多
建立了甲基环己基二甲氧基硅烷(MCDS)的毛细管气相色谱分析法。色谱柱为OV-17毛细管柱(30 m×0.53 mm id),载气为高纯氮,检测器为FID。定量采用外标法,自动进样器进样,该方法克服了注射器进样因样品粘度大进样体积重复性差导致结果...建立了甲基环己基二甲氧基硅烷(MCDS)的毛细管气相色谱分析法。色谱柱为OV-17毛细管柱(30 m×0.53 mm id),载气为高纯氮,检测器为FID。定量采用外标法,自动进样器进样,该方法克服了注射器进样因样品粘度大进样体积重复性差导致结果离散的问题,同时较低的分流比也节约了大量的载气。展开更多
Sepsis,caused by uncontrollable infection and inflammatory response,leads to more than 30 million infected patients and results in high morbidity worldwide every year.Currently,no efficient approaches have been develo...Sepsis,caused by uncontrollable infection and inflammatory response,leads to more than 30 million infected patients and results in high morbidity worldwide every year.Currently,no efficient approaches have been developed for sepsis therapy due to antimicrobial resistance and inflammatory storm.Here,we report macrophages loaded with aggregated carbon dots(ACDs)in the lysosome,termed MCDs,to treat sepsis in immunosuppressive mice.The ACDs are constructed by negative CDs and amine-abundant polyethyleneimine(PEI),enabling them to bear the strong antibacterial ability and enhanced photoluminescent efficacy.The ACDs are specifically located in the macrophage lysosomes,efficiently enhancing the multidrug-resistant bacteria-killing ability of MCDs.More importantly,the MCDs possess superior anti-inflammatory effects such as reducing the number of pro-inflammatory(M1)and stimulating anti-inflammatory(M2)macrophages.These effects upregulate the inflammatory cytokines(TNF-α,IL-1β,IL-4,and IL-10),ultimately resulting in increased sepsis survival.Our work provides an intelligent approach to overcoming multidrug-resistant bacteria-induced infection from sepsis patients and paves a new avenue on employing nanoparticle-loaded cells for combating inflammation-related infection.展开更多
文摘移动数据具有数量庞大、类型多样、时效性强和高价值等特点.移动通信数据是一种重要的移动数据,对高效地存储和访问移动通信数据进行研究,并在此基础上更加有效地开展移动数据挖掘的相关研究,具有重大现实意义.当前,使用并行数据挖掘技术进行数据挖掘得到普遍认可,但并行数据挖掘技术需要较高的硬件成本,并行算法代码调试和优化较为困难.为此提出大规模移动通信数据的单机实现MCDS(mobile communication data processing system).MCDS基于GraphChi,改进了数据格式、分片机制、数据分片换入换出机制.实验结果验证了MCDS的有效性,为移动数据挖掘提供了切实可行的实验环境.
基金National Natural Science Foundation of China,Grant/Award Numbers:52002133,U1609219,81871482Foundation for Basic and Applied Basic Research of Guangdong Province,Grant/Award Number:2019A1515110328+1 种基金NSFC Development of National Major Scientific Research Instrument,Grant/Award Number:61927816Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program,Grant/Award Number:2017BT01X137。
文摘Sepsis,caused by uncontrollable infection and inflammatory response,leads to more than 30 million infected patients and results in high morbidity worldwide every year.Currently,no efficient approaches have been developed for sepsis therapy due to antimicrobial resistance and inflammatory storm.Here,we report macrophages loaded with aggregated carbon dots(ACDs)in the lysosome,termed MCDs,to treat sepsis in immunosuppressive mice.The ACDs are constructed by negative CDs and amine-abundant polyethyleneimine(PEI),enabling them to bear the strong antibacterial ability and enhanced photoluminescent efficacy.The ACDs are specifically located in the macrophage lysosomes,efficiently enhancing the multidrug-resistant bacteria-killing ability of MCDs.More importantly,the MCDs possess superior anti-inflammatory effects such as reducing the number of pro-inflammatory(M1)and stimulating anti-inflammatory(M2)macrophages.These effects upregulate the inflammatory cytokines(TNF-α,IL-1β,IL-4,and IL-10),ultimately resulting in increased sepsis survival.Our work provides an intelligent approach to overcoming multidrug-resistant bacteria-induced infection from sepsis patients and paves a new avenue on employing nanoparticle-loaded cells for combating inflammation-related infection.
