为确保完成欧盟“到2030年将其温室气体排放量相比1990年减少至少55%”的国家自主贡献更新目标,今年7月14日欧盟正式提出了包含能源、交通、林业碳汇、减排责任和资金支持等在内的一揽子“Fit for 55”立法提案,把目标通过政策手段分解...为确保完成欧盟“到2030年将其温室气体排放量相比1990年减少至少55%”的国家自主贡献更新目标,今年7月14日欧盟正式提出了包含能源、交通、林业碳汇、减排责任和资金支持等在内的一揽子“Fit for 55”立法提案,把目标通过政策手段分解落地。提前研判该法案,分析其落地实施面临的内部挑战,有助于判断法案最终立法的可能性与实施时间,分析其对我国经济的主要影响,可以使我国提前布局、积极应对。基于以上研究需求,本文对欧盟“Fit for 55”一揽子气候立法提案基本情况进行解读,探讨该立法提案落地面临的欧盟内部挑战及对我国经济的主要影响,并提出对内推进调整、提升产品绿色竞争力等建议。展开更多
Mesangial proliferative glomerulonephritis(MsPGN)is an inflammatory disease,but both the nature of disease progression and its regulation remain unclear.In the present study,we monitored the course of anti-Thy1 nephri...Mesangial proliferative glomerulonephritis(MsPGN)is an inflammatory disease,but both the nature of disease progression and its regulation remain unclear.In the present study,we monitored the course of anti-Thy1 nephritis from days 1 to 5 and established gene expression profiles at each time point using microarrays to explore the development of inflammation.According to the gene expression profiles,macrophage infiltration(triggered by CCL2 activation)was evident on day 1 and enhanced inflammation over the next few days.We screened for genes with expression levels similar to CCL2 and found that the upregulation of the circadian gene albumin D-site-binding protein(DBP)was involved in CCL2 activation in mesangial cells.More importantly,CCL2 expression showed oscillatory changes similar to DBP,and DBP induced peak CCL2 expression at 16:00 a clock on day 1 in the anti-Thy1 nephritis model.We knocked down DBP through transfection with a small interfering RNA(siRNA)and used RNA sequencing to identify the DBP-regulated TNF-α-CCL2 pathway.We performed chromatin immunoprecipitation sequencing(ChIP-Seq)and the dual luciferase assay to show that DBP bound to the TRIM55 promoter,regulating gene expression and in turn controlling the TNF-α-CCL2 pathway.In conclusion,DBP-regulated circadian CCL2 expression by the TRIM55-TNF pathway in injured mesangial cells at an early stage,which promoted macrophage recruitment and in turn triggered infiltration and inflammation in a model of anti-Thy1 nephritis.展开更多
The thermal stability of the rare earth rich phase particles in α, α+β and β phase regions of Ti 5Al 4Sn 2Zr 1Mo 0 25Si 1Nd(Ti 55) high temperature titanium alloy heat treated was studied. Under ...The thermal stability of the rare earth rich phase particles in α, α+β and β phase regions of Ti 5Al 4Sn 2Zr 1Mo 0 25Si 1Nd(Ti 55) high temperature titanium alloy heat treated was studied. Under conditions of 600～980 ℃/1～100 h and 1050～1500 ℃/1～10 h, the average particle size ranges from 3 34 to 4 20 μm, the circularity shape factor from 0 619 to 0 759, and the volume fraction from 1 4% to 1 8%. The results show that nearly no change is found for the size, shape, and volume fraction of the particles in the alloy, and the rare earth rich phase particles exhibit thermal stability.展开更多
文摘为确保完成欧盟“到2030年将其温室气体排放量相比1990年减少至少55%”的国家自主贡献更新目标,今年7月14日欧盟正式提出了包含能源、交通、林业碳汇、减排责任和资金支持等在内的一揽子“Fit for 55”立法提案,把目标通过政策手段分解落地。提前研判该法案,分析其落地实施面临的内部挑战,有助于判断法案最终立法的可能性与实施时间,分析其对我国经济的主要影响,可以使我国提前布局、积极应对。基于以上研究需求,本文对欧盟“Fit for 55”一揽子气候立法提案基本情况进行解读,探讨该立法提案落地面临的欧盟内部挑战及对我国经济的主要影响,并提出对内推进调整、提升产品绿色竞争力等建议。
基金supported by grants from the National Natural Science Foundation of China(No.81330019)the National Basic Research Program of China(Nos.2014CBA02005 and 2015CB553605).
文摘Mesangial proliferative glomerulonephritis(MsPGN)is an inflammatory disease,but both the nature of disease progression and its regulation remain unclear.In the present study,we monitored the course of anti-Thy1 nephritis from days 1 to 5 and established gene expression profiles at each time point using microarrays to explore the development of inflammation.According to the gene expression profiles,macrophage infiltration(triggered by CCL2 activation)was evident on day 1 and enhanced inflammation over the next few days.We screened for genes with expression levels similar to CCL2 and found that the upregulation of the circadian gene albumin D-site-binding protein(DBP)was involved in CCL2 activation in mesangial cells.More importantly,CCL2 expression showed oscillatory changes similar to DBP,and DBP induced peak CCL2 expression at 16:00 a clock on day 1 in the anti-Thy1 nephritis model.We knocked down DBP through transfection with a small interfering RNA(siRNA)and used RNA sequencing to identify the DBP-regulated TNF-α-CCL2 pathway.We performed chromatin immunoprecipitation sequencing(ChIP-Seq)and the dual luciferase assay to show that DBP bound to the TRIM55 promoter,regulating gene expression and in turn controlling the TNF-α-CCL2 pathway.In conclusion,DBP-regulated circadian CCL2 expression by the TRIM55-TNF pathway in injured mesangial cells at an early stage,which promoted macrophage recruitment and in turn triggered infiltration and inflammation in a model of anti-Thy1 nephritis.
文摘The thermal stability of the rare earth rich phase particles in α, α+β and β phase regions of Ti 5Al 4Sn 2Zr 1Mo 0 25Si 1Nd(Ti 55) high temperature titanium alloy heat treated was studied. Under conditions of 600～980 ℃/1～100 h and 1050～1500 ℃/1～10 h, the average particle size ranges from 3 34 to 4 20 μm, the circularity shape factor from 0 619 to 0 759, and the volume fraction from 1 4% to 1 8%. The results show that nearly no change is found for the size, shape, and volume fraction of the particles in the alloy, and the rare earth rich phase particles exhibit thermal stability.
