Objective： To evaluate the long-term clinical effect of Tangyiping Granules（糖异平颗粒, TYP） on patients with impaired glucose tolerance（IGT） to achieve normal glucose tolerance（NGT） and hence preventing them f...Objective： To evaluate the long-term clinical effect of Tangyiping Granules（糖异平颗粒, TYP） on patients with impaired glucose tolerance（IGT） to achieve normal glucose tolerance（NGT） and hence preventing them from conversion to diabetes mellitus（DM）. Methods： In total, 127 participants with IGT were randomly assigned to the control（63 cases, 3 lost to follow-up） and treatment groups（64 cases, 4 lost to follow-up） according to the random number table. The control group received lifestyle intervention alone, while the patients in the treatment group took orally 10 g of TYP twice daily in addition to lifestyle intervention for 12 weeks. The rates of patients achieving NGT or experiencing conversion to DM as main outcome measure were observed at 3, 12, and 24 months after TYP treatment. The secondary outcome measures included fasting plasma glucose（FPG）, 2-h postprandial plasma glucose（2h PG）, glycosylated hemoglobin（Hb A1c）, fasting insulin（FINS）, 2-h insulin（2hI NS）, homeostatic model assessment of insulin resistance（HOMA-IR）, blood lipid and patients＇ complains of Chinese medicine（CM） symptoms before and after treatment. Results： A higher proportion of the treatment group achieved NGT compared with the control group after 3-, 12- and 24-month follow-up（75.00% vs. 43.33%, 58.33% vs. 35.00%, 46.67% vs. 26.67%, respectively, P〈0.05）. The IGT to DM conversion rate of the treatment group was significantly lower than that of the control group at the end of 24-month follow-up（16.67% vs. 31.67%, P〈0.05）. Before treatment, FPG, 2h PG, Hb A1 c, FINS, 2h INS, HOMA-IR, triglyceride（TG）, total cholesterol, low- and high-density lipoprotein cholesterol levels had no statistical difference between the two groups（P〉0.05）. After treatment, the 2hP G, HbA 1c, HOMA-IR, and TG levels of the treatment group decreased significantly compared with those of the control group（P〈0.05）. CM symptoms such as exhaustion, irritability, chest tightness an展开更多
[目的]观察揿针结合耳穴治疗老年功能性消化不良(functional dyspepsia,FD)的临床疗效。[方法]选取我院符合纳入标准的90例老年FD患者,随机分为观察组与对照组,每组45例。对照组予采用枸橼酸莫沙必利分散片治疗,观察组在对照组基础上加...[目的]观察揿针结合耳穴治疗老年功能性消化不良(functional dyspepsia,FD)的临床疗效。[方法]选取我院符合纳入标准的90例老年FD患者,随机分为观察组与对照组,每组45例。对照组予采用枸橼酸莫沙必利分散片治疗,观察组在对照组基础上加揿针结合耳穴治疗,观察患者治疗前后的FD症状评分及功能性消化不良生存质量量表(functional digestive disorder quality of life questionnaire,FDDQL)评分,治疗结束后2个月进行随访并评价临床疗效。[结果]观察组的总有效率为91.1%,高于对照组的73.3%,差异有统计学意义(P<0.05);治疗结束后及随访时两组症状评分较治疗前降低,FDDQL评分较治疗前升高,差异均有统计学意义(P<0.05),组间治疗后同一时间点比较,观察组的改善优于对照组(P<0.05)。[结论]揿针联合莫沙必利治疗老年FD疗效确切,具有良好的近期及远期疗效。展开更多
基金Supported by Shandong Province Science and Technology Program for Public Wellbing(No.2014kjhm0106)Shandong Province Science and Technology Development Plan(No.2006GG3202011),China
文摘Objective： To evaluate the long-term clinical effect of Tangyiping Granules（糖异平颗粒, TYP） on patients with impaired glucose tolerance（IGT） to achieve normal glucose tolerance（NGT） and hence preventing them from conversion to diabetes mellitus（DM）. Methods： In total, 127 participants with IGT were randomly assigned to the control（63 cases, 3 lost to follow-up） and treatment groups（64 cases, 4 lost to follow-up） according to the random number table. The control group received lifestyle intervention alone, while the patients in the treatment group took orally 10 g of TYP twice daily in addition to lifestyle intervention for 12 weeks. The rates of patients achieving NGT or experiencing conversion to DM as main outcome measure were observed at 3, 12, and 24 months after TYP treatment. The secondary outcome measures included fasting plasma glucose（FPG）, 2-h postprandial plasma glucose（2h PG）, glycosylated hemoglobin（Hb A1c）, fasting insulin（FINS）, 2-h insulin（2hI NS）, homeostatic model assessment of insulin resistance（HOMA-IR）, blood lipid and patients＇ complains of Chinese medicine（CM） symptoms before and after treatment. Results： A higher proportion of the treatment group achieved NGT compared with the control group after 3-, 12- and 24-month follow-up（75.00% vs. 43.33%, 58.33% vs. 35.00%, 46.67% vs. 26.67%, respectively, P〈0.05）. The IGT to DM conversion rate of the treatment group was significantly lower than that of the control group at the end of 24-month follow-up（16.67% vs. 31.67%, P〈0.05）. Before treatment, FPG, 2h PG, Hb A1 c, FINS, 2h INS, HOMA-IR, triglyceride（TG）, total cholesterol, low- and high-density lipoprotein cholesterol levels had no statistical difference between the two groups（P〉0.05）. After treatment, the 2hP G, HbA 1c, HOMA-IR, and TG levels of the treatment group decreased significantly compared with those of the control group（P〈0.05）. CM symptoms such as exhaustion, irritability, chest tightness an
文摘[目的]观察揿针结合耳穴治疗老年功能性消化不良(functional dyspepsia,FD)的临床疗效。[方法]选取我院符合纳入标准的90例老年FD患者,随机分为观察组与对照组,每组45例。对照组予采用枸橼酸莫沙必利分散片治疗,观察组在对照组基础上加揿针结合耳穴治疗,观察患者治疗前后的FD症状评分及功能性消化不良生存质量量表(functional digestive disorder quality of life questionnaire,FDDQL)评分,治疗结束后2个月进行随访并评价临床疗效。[结果]观察组的总有效率为91.1%,高于对照组的73.3%,差异有统计学意义(P<0.05);治疗结束后及随访时两组症状评分较治疗前降低,FDDQL评分较治疗前升高,差异均有统计学意义(P<0.05),组间治疗后同一时间点比较,观察组的改善优于对照组(P<0.05)。[结论]揿针联合莫沙必利治疗老年FD疗效确切,具有良好的近期及远期疗效。
