目的：比较老年人股骨颈骨折半髋与全髋置换远期的临床疗效。方法对70例老年人股骨颈骨折需行髋关节置换的患者，采用随机序号的方式将其分为观察组和对照组各35例，其中观察组采用全髋关节置换术，对照组予以半髋关节置换术，比较两组...目的：比较老年人股骨颈骨折半髋与全髋置换远期的临床疗效。方法对70例老年人股骨颈骨折需行髋关节置换的患者，采用随机序号的方式将其分为观察组和对照组各35例，其中观察组采用全髋关节置换术，对照组予以半髋关节置换术，比较两组患者术后远期疗效。结果观察组术后感染总发生率高于对照组，观察组术后翻修率低于对照组，但两组差异无统计学意义（P＞0．05）；对照组术后慢性疼痛总发生率为22．86％明显高于观察组的2．28％，两组差异有统计学意义（χ2＝5．130，P＜0．05）；观察组术后Harris评分为（93．25±4．51）分显著高于对照组的（82．76±3．82）分，两组差异有统计学意义（t＝6．973，P＜0．05），观察组的优良率为91．43％明显高于对照组的71．43％，两组差异有统计学意义（χ2＝6．492， P ＜0．05）。结论全髋关节置换术可减少股骨颈骨折术后疼痛感发生率，明显改善患者髋关节功能，中远期疗效优于半髋关节置换术。展开更多
Background Homoharringtonine （HHT） is effective in treating late stage chronic myelogenous leukaemia （CML）, but little is known about long term maintenance during complete cytogenetic response. Long term efficacy ...Background Homoharringtonine （HHT） is effective in treating late stage chronic myelogenous leukaemia （CML）, but little is known about long term maintenance during complete cytogenetic response. Long term efficacy and toxicity profiles of low dose HHT were evaluated in this study. Methods One hundred and six patients with CML received 1.5 mg/m^2 of HHT alone by continuous daily infusion for seven to nine days every four weeks. Of 79 patients in the control group, 31 were treated with interferon α （IFN-α） and 48 with hydroxycarbamide. For 17 patients who failed to achieve cytogenetic response within 12 months＇ treatment of IFN-α, HHT was administered. Quantitative RT-PCR was used to detect the BCR-ABL mRNA expression in 36 Philadelphia positive CML patients enrolled after 2007. Haematological and cytogenetic responses were evaluated in all patients at the 12th month of follow-up. Long term efficacy was assessed in a follow-up with a median time of 54 months （12 months-98 months）. Results After 12 months of therapy, cytogenetic response rate of the HHT, IFN-α and hydroxycarbamide groups were 39/106, 14/31 and 3/48, and corresponding molecular cytogenetic response rates 6/18, 3/8 and 0. Of the 17 patients who received HHT as salvage treatment, 6 achieved cytogenetic response （3 major）. At the 48 months＇ follow-up, cytogenetic response was maintained in 32/39 patients treated with HHT. Patients who had cytogenetic response in HHT group or treated with IFN-α also showed longer median chronic durations, which were 45 months （12 months-98 months） and 49 months （12 months-92 months） respectively, indicating a longer survival time. Conclusions Low dose HHT alone showed considerable short term and long term efficacy in the treatment of late stage CML. It may also be a good choice for patients who have failed imatinib, IFN-α treatment or haematopoietic stem cell transplantation or cannot afford these treatments.展开更多
文摘目的：比较老年人股骨颈骨折半髋与全髋置换远期的临床疗效。方法对70例老年人股骨颈骨折需行髋关节置换的患者，采用随机序号的方式将其分为观察组和对照组各35例，其中观察组采用全髋关节置换术，对照组予以半髋关节置换术，比较两组患者术后远期疗效。结果观察组术后感染总发生率高于对照组，观察组术后翻修率低于对照组，但两组差异无统计学意义（P＞0．05）；对照组术后慢性疼痛总发生率为22．86％明显高于观察组的2．28％，两组差异有统计学意义（χ2＝5．130，P＜0．05）；观察组术后Harris评分为（93．25±4．51）分显著高于对照组的（82．76±3．82）分，两组差异有统计学意义（t＝6．973，P＜0．05），观察组的优良率为91．43％明显高于对照组的71．43％，两组差异有统计学意义（χ2＝6．492， P ＜0．05）。结论全髋关节置换术可减少股骨颈骨折术后疼痛感发生率，明显改善患者髋关节功能，中远期疗效优于半髋关节置换术。
文摘Background Homoharringtonine （HHT） is effective in treating late stage chronic myelogenous leukaemia （CML）, but little is known about long term maintenance during complete cytogenetic response. Long term efficacy and toxicity profiles of low dose HHT were evaluated in this study. Methods One hundred and six patients with CML received 1.5 mg/m^2 of HHT alone by continuous daily infusion for seven to nine days every four weeks. Of 79 patients in the control group, 31 were treated with interferon α （IFN-α） and 48 with hydroxycarbamide. For 17 patients who failed to achieve cytogenetic response within 12 months＇ treatment of IFN-α, HHT was administered. Quantitative RT-PCR was used to detect the BCR-ABL mRNA expression in 36 Philadelphia positive CML patients enrolled after 2007. Haematological and cytogenetic responses were evaluated in all patients at the 12th month of follow-up. Long term efficacy was assessed in a follow-up with a median time of 54 months （12 months-98 months）. Results After 12 months of therapy, cytogenetic response rate of the HHT, IFN-α and hydroxycarbamide groups were 39/106, 14/31 and 3/48, and corresponding molecular cytogenetic response rates 6/18, 3/8 and 0. Of the 17 patients who received HHT as salvage treatment, 6 achieved cytogenetic response （3 major）. At the 48 months＇ follow-up, cytogenetic response was maintained in 32/39 patients treated with HHT. Patients who had cytogenetic response in HHT group or treated with IFN-α also showed longer median chronic durations, which were 45 months （12 months-98 months） and 49 months （12 months-92 months） respectively, indicating a longer survival time. Conclusions Low dose HHT alone showed considerable short term and long term efficacy in the treatment of late stage CML. It may also be a good choice for patients who have failed imatinib, IFN-α treatment or haematopoietic stem cell transplantation or cannot afford these treatments.
