OBJECTIVE: To investigate the effect of the clinical effective prescription of Qingre Lishi Yishen decoction(QRLS) on the activation of mesangial cells in immunoglobulin A nephropathy(IgAN) rats.METHODS: IgAN rat’s m...OBJECTIVE: To investigate the effect of the clinical effective prescription of Qingre Lishi Yishen decoction(QRLS) on the activation of mesangial cells in immunoglobulin A nephropathy(IgAN) rats.METHODS: IgAN rat’s model was established by combine with intragastric administration of bovine serum albumin(BSA) + intravenous injection of lipopolysaccharide(LPS) by + subcutaneous injection of carbon tetrachloride(CCL4). Then the animals were randomly divided into four groups: control group, IgAN model group, IgAN model with Valsartan(Val) treatment group and IgAN model with QRLS treatment group. To observe the indexes of 24-h urine protein, renal function, deposition of immune complexes, expression of activation factor, fibrosis marker and inflammatory cytokines in four different groups.RESULTS: The Val or QRLS treatment group:(a) it reduced the immune complexes deposition of IgA in glomerular mesangial and inhibited mesangial cell proliferation;(b) it decreased the expression of smooth muscle actin(α-SMA), fibronectin(FN) and tumor necrosis factor alpha(TNF-α).CONCLUSION: The study suggested that QRLS ameliorate renal structure and function in IgAN rat’s model. Furthermore, we also observed that QRLS alleviated mesangial cells activation and matrix accumulation partly by decreasing the α-SMA,then to downregulated the expression of FN and TNF-α.展开更多
Is Laozi a syncretic text whose primary body of ideas were cobbled together from multiple and various sources, none of which can reasonably be identified as Daoist, or is it a synthetic text whose ideas emerged from a...Is Laozi a syncretic text whose primary body of ideas were cobbled together from multiple and various sources, none of which can reasonably be identified as Daoist, or is it a synthetic text whose ideas emerged from a single source that for all intents embodies the core elements of a tradition that meets the standards of inclusion for a tradition of early Daoism？ The present work examines the key points of Hongkyung Kim＇s sophisticated account of Laozi＇s origins as a syncretic text. It then goes on to present the key points of what would have to be involved in its original circulations as a synthetic text. It concludes by suggesting a middle ground that is able to explain why an originally synthetic Laozi is all too easily read by modem scholars as a syncretic text.展开更多
Lu Yin庐隐(1898-1934)was a leading“new woman”,and she had scaled the heights of her writing profession in mid-Republican China.In her short 36-year life,she published over 200 works in all,including novels,essays,pr...Lu Yin庐隐(1898-1934)was a leading“new woman”,and she had scaled the heights of her writing profession in mid-Republican China.In her short 36-year life,she published over 200 works in all,including novels,essays,proses and travelogues.As the first May Fourth female writer who touched upon the theme of homosexuality and depicted a lesbian story without reservation,Lu Yin created a short story“The Diary of Lishi”in which she narrated the love between Lishi and her same-sex partner Yuanqing;but this finally ended in tragedy,which implied Lu Yin’s deconstruction of binary gender order.Meanwhile,this paper distinguishes“Old Friends on the Seashore”from lesbian or quasi-lesbian stories and argued that this fiction was more in terms of female same-sex camaraderie instead of lesbian love.展开更多
Objective:To assess the efficacy of Qingre Lishi Tuihuang therapy (QLTT) for acute icteric hepatitis B infection.Methods:Eight electronic databases were searched from inception to December 2016 with no language restri...Objective:To assess the efficacy of Qingre Lishi Tuihuang therapy (QLTT) for acute icteric hepatitis B infection.Methods:Eight electronic databases were searched from inception to December 2016 with no language restrictions for reports of randomized controlled trials evaluating the effect of QLTT treating acute icteric hepatitis B.Two researchers independently extracted detailed data and assessed methodological quality.ReviewManager 5.3.0 software was used to analyze the data.Results:A total of 13 randomized controlled trials involving 2238 participants were included in this review.The methodological quality was generally poor.The results indicated that supplemented Yinchenhao decoction combined with non-specific treatments was more effective in improving the cure rate (risk ratio =1.80;95% CI 1.21-2.68) and reducing the serum levels of total bilirubin (mean difference =-29.74;95% CI-31.91 to-27.57) and aspartate aminotransferase.Other self-made prescriptions conforming to QLTT plus non-specific treatments had beneficial effect for acute icteric hepatitis B in curing this disease (risk ratio =1.48;95% CI 1.27-1.73),as well as for negative seroconversion of HBeAg (risk ratio =1.39;95% CI 1.11-1.74).Supplemented Yinchenhao decoction plus non-specific treatments was more effective than other self-made prescriptions conforming to QLTT in reducing serum total bilirubin level.Conclusion:Qingre Lishi Tuihuang therapy appears to improve effect based on non-specific treatments for the treatment of acute icteric hepatitis B.However,it is premature to draw confirmative conclusions,owing to the poor methodological quality and high clinical heterogeneity of the included trials.Further well-designed clinical randomized controlled trials with large sample sizes should be undertaken.展开更多
基金Supported by Monographic Research of Capital Traditional Chinese Medicine(No.3500-11723360)
文摘OBJECTIVE: To investigate the effect of the clinical effective prescription of Qingre Lishi Yishen decoction(QRLS) on the activation of mesangial cells in immunoglobulin A nephropathy(IgAN) rats.METHODS: IgAN rat’s model was established by combine with intragastric administration of bovine serum albumin(BSA) + intravenous injection of lipopolysaccharide(LPS) by + subcutaneous injection of carbon tetrachloride(CCL4). Then the animals were randomly divided into four groups: control group, IgAN model group, IgAN model with Valsartan(Val) treatment group and IgAN model with QRLS treatment group. To observe the indexes of 24-h urine protein, renal function, deposition of immune complexes, expression of activation factor, fibrosis marker and inflammatory cytokines in four different groups.RESULTS: The Val or QRLS treatment group:(a) it reduced the immune complexes deposition of IgA in glomerular mesangial and inhibited mesangial cell proliferation;(b) it decreased the expression of smooth muscle actin(α-SMA), fibronectin(FN) and tumor necrosis factor alpha(TNF-α).CONCLUSION: The study suggested that QRLS ameliorate renal structure and function in IgAN rat’s model. Furthermore, we also observed that QRLS alleviated mesangial cells activation and matrix accumulation partly by decreasing the α-SMA,then to downregulated the expression of FN and TNF-α.
文摘Is Laozi a syncretic text whose primary body of ideas were cobbled together from multiple and various sources, none of which can reasonably be identified as Daoist, or is it a synthetic text whose ideas emerged from a single source that for all intents embodies the core elements of a tradition that meets the standards of inclusion for a tradition of early Daoism？ The present work examines the key points of Hongkyung Kim＇s sophisticated account of Laozi＇s origins as a syncretic text. It then goes on to present the key points of what would have to be involved in its original circulations as a synthetic text. It concludes by suggesting a middle ground that is able to explain why an originally synthetic Laozi is all too easily read by modem scholars as a syncretic text.
文摘Lu Yin庐隐(1898-1934)was a leading“new woman”,and she had scaled the heights of her writing profession in mid-Republican China.In her short 36-year life,she published over 200 works in all,including novels,essays,proses and travelogues.As the first May Fourth female writer who touched upon the theme of homosexuality and depicted a lesbian story without reservation,Lu Yin created a short story“The Diary of Lishi”in which she narrated the love between Lishi and her same-sex partner Yuanqing;but this finally ended in tragedy,which implied Lu Yin’s deconstruction of binary gender order.Meanwhile,this paper distinguishes“Old Friends on the Seashore”from lesbian or quasi-lesbian stories and argued that this fiction was more in terms of female same-sex camaraderie instead of lesbian love.
基金The study was partially supported by Chinese National Natural Science Foundation Project(81373886).We really appreciate Mei Han,Centre for Evidence-Based Chinese Medicine,Beijing University of Chinese Medicine,for her suggestions in data synthesis.
文摘Objective:To assess the efficacy of Qingre Lishi Tuihuang therapy (QLTT) for acute icteric hepatitis B infection.Methods:Eight electronic databases were searched from inception to December 2016 with no language restrictions for reports of randomized controlled trials evaluating the effect of QLTT treating acute icteric hepatitis B.Two researchers independently extracted detailed data and assessed methodological quality.ReviewManager 5.3.0 software was used to analyze the data.Results:A total of 13 randomized controlled trials involving 2238 participants were included in this review.The methodological quality was generally poor.The results indicated that supplemented Yinchenhao decoction combined with non-specific treatments was more effective in improving the cure rate (risk ratio =1.80;95% CI 1.21-2.68) and reducing the serum levels of total bilirubin (mean difference =-29.74;95% CI-31.91 to-27.57) and aspartate aminotransferase.Other self-made prescriptions conforming to QLTT plus non-specific treatments had beneficial effect for acute icteric hepatitis B in curing this disease (risk ratio =1.48;95% CI 1.27-1.73),as well as for negative seroconversion of HBeAg (risk ratio =1.39;95% CI 1.11-1.74).Supplemented Yinchenhao decoction plus non-specific treatments was more effective than other self-made prescriptions conforming to QLTT in reducing serum total bilirubin level.Conclusion:Qingre Lishi Tuihuang therapy appears to improve effect based on non-specific treatments for the treatment of acute icteric hepatitis B.However,it is premature to draw confirmative conclusions,owing to the poor methodological quality and high clinical heterogeneity of the included trials.Further well-designed clinical randomized controlled trials with large sample sizes should be undertaken.
