目的观察不同光照时间全光谱治疗对阿尔茨海默病（Alzheimer’sdisease，AD）患者睡眠障碍的临床疗效和安全性。方法将127例AD伴发睡眠障碍的患者按随机数字表法分为空白组34例、30min光照组31例、60min光照组33例和120min光照组29例，...目的观察不同光照时间全光谱治疗对阿尔茨海默病（Alzheimer’sdisease，AD）患者睡眠障碍的临床疗效和安全性。方法将127例AD伴发睡眠障碍的患者按随机数字表法分为空白组34例、30min光照组31例、60min光照组33例和120min光照组29例，通过10000lux全光谱光照治疗1个月后，采用匹兹堡睡眠质量指数量表（pQsI）、爱泼沃斯嗜睡量表（ESS）、神经精神问卷（NPI）、简易智能状态量表（MMSE）和总体衰退量表（GDS）等评分作为主要评价指标，比较光照前后患者的睡眠质量、日间过度嗜睡、认知功能、精神状况和痴呆程度的变化。结果（1）与治疗前相比，30min组、60min组和120min组的PQSI，ESS，NPI评分差异有统计学意义[30min组：（14．4±5．2）分 vs（11．7±4．9）分，（14．4±4．1）分vs（11．8±3．7）分。（14．2±1．3）分vs（10．9±1．7）分，t=2．071，2．609，8．446，P=0．043，0．011，0．000。60min组：（13．4±4．0）分 vs（8．1±3．7）分，（14．5±3．0）分vs（9．4±2．0）分，（13．7±5．8）分vs（8．7±4．3）分，t=5．650，8．209，3．902，均P〈0．01。120min组：（14．0±3．2）分 vs （7．0±2．3）分，（14．7±2．3）分 vs （7．0±1．9）分，（14．9±3．6）分F5（8．1±3．7）分，t=9．474，13．926，7．062，均P〈0．01]，MMSE，GDS评分差异无统计学意义（均P〉0．05）。（2）与空白组相比，30min组、60min组和120min组的PQSI，NPI，ESS评分差异有统计学意义（30min组：t=1．936，4．524，2．482，P=0．031，0．000，0．016。60min组：t=5．945，5．153，7．319，均P=0．000。120min组：t=7．896，6．767，10．776，均P=0．000），MMSE，GDS评分差异无统计学意义（均P〉0．05）。（3）与30min组相比，60min组和120min组PQSI，NPI，ESS评分差异有统计学意义（60min组：t=3．288，2．694，3．354，P=0．002，0．009，0．001。120min组�展开更多
AIM： To investigate if high-definition （HD） colonoscope with i-Scan gave a higher detection rate of mucosal le- sions vs standard white-light instruments. METHODS： Data were collected from the computer- ized datab...AIM： To investigate if high-definition （HD） colonoscope with i-Scan gave a higher detection rate of mucosal le- sions vs standard white-light instruments. METHODS： Data were collected from the computer- ized database of the endoscopy unit of our tertiary referral center. We retrospectively analyzed 1101 con- secutive colonoscopies that were performed over 1 year with standard white-light （n = 849） or HD＋ with i-Scan （n = 252） instruments by four endoscopists, in an outpatient setting. Colonoscopy records included patients＇ main details and family history for colorectal cancer, indication for colonoscopy （screening, diagnos- tic or surveillance）, type of instrument used （standard white-light or HD＋ plus i-Scan）, name of endoscopist and bowel preparation. Records for each procedure included whether the cecum was reached or not and the reason for failure, complications during or imme- diately after the procedure, and number, size, location and characteristics of the lesions. Polyps or protruding lesions were defined as sessile or pedunculated, and nonprotruding lesions were defined according to Paris classification. For each lesion, histological diagnosis was recorded. RESULTS： Eight hundred and forty-nine colonosco- pies were carried with the standard white-light video colonoscope and 252 with the HD＋ plus i-Scan video colonoscope, The four endoscopists did 264, 300, 276 and 261 procedures, respectively; 21.6%, 24.0%, 21.7% and 24.1% of them with the HD＋ plus i-Scan technique. There were no significant differences be- tween the four endoscopists in either the number of procedures done or the proportions of each imaging technique used. Both techniques detected one or more mucosal lesions in 522/1101 procedures （47.4%）. The overall number of lesions recognized was 1266; 645 in the right colon and 621 in the left. A significantly higher number of colonoscopies recognized lesions in the HD＋ plus i-Scan mode （171/252 = 67.9%） than with the standard white-light technique （4展开更多
文摘目的观察不同光照时间全光谱治疗对阿尔茨海默病（Alzheimer’sdisease，AD）患者睡眠障碍的临床疗效和安全性。方法将127例AD伴发睡眠障碍的患者按随机数字表法分为空白组34例、30min光照组31例、60min光照组33例和120min光照组29例，通过10000lux全光谱光照治疗1个月后，采用匹兹堡睡眠质量指数量表（pQsI）、爱泼沃斯嗜睡量表（ESS）、神经精神问卷（NPI）、简易智能状态量表（MMSE）和总体衰退量表（GDS）等评分作为主要评价指标，比较光照前后患者的睡眠质量、日间过度嗜睡、认知功能、精神状况和痴呆程度的变化。结果（1）与治疗前相比，30min组、60min组和120min组的PQSI，ESS，NPI评分差异有统计学意义[30min组：（14．4±5．2）分 vs（11．7±4．9）分，（14．4±4．1）分vs（11．8±3．7）分。（14．2±1．3）分vs（10．9±1．7）分，t=2．071，2．609，8．446，P=0．043，0．011，0．000。60min组：（13．4±4．0）分 vs（8．1±3．7）分，（14．5±3．0）分vs（9．4±2．0）分，（13．7±5．8）分vs（8．7±4．3）分，t=5．650，8．209，3．902，均P〈0．01。120min组：（14．0±3．2）分 vs （7．0±2．3）分，（14．7±2．3）分 vs （7．0±1．9）分，（14．9±3．6）分F5（8．1±3．7）分，t=9．474，13．926，7．062，均P〈0．01]，MMSE，GDS评分差异无统计学意义（均P〉0．05）。（2）与空白组相比，30min组、60min组和120min组的PQSI，NPI，ESS评分差异有统计学意义（30min组：t=1．936，4．524，2．482，P=0．031，0．000，0．016。60min组：t=5．945，5．153，7．319，均P=0．000。120min组：t=7．896，6．767，10．776，均P=0．000），MMSE，GDS评分差异无统计学意义（均P〉0．05）。（3）与30min组相比，60min组和120min组PQSI，NPI，ESS评分差异有统计学意义（60min组：t=3．288，2．694，3．354，P=0．002，0．009，0．001。120min组�
文摘AIM： To investigate if high-definition （HD） colonoscope with i-Scan gave a higher detection rate of mucosal le- sions vs standard white-light instruments. METHODS： Data were collected from the computer- ized database of the endoscopy unit of our tertiary referral center. We retrospectively analyzed 1101 con- secutive colonoscopies that were performed over 1 year with standard white-light （n = 849） or HD＋ with i-Scan （n = 252） instruments by four endoscopists, in an outpatient setting. Colonoscopy records included patients＇ main details and family history for colorectal cancer, indication for colonoscopy （screening, diagnos- tic or surveillance）, type of instrument used （standard white-light or HD＋ plus i-Scan）, name of endoscopist and bowel preparation. Records for each procedure included whether the cecum was reached or not and the reason for failure, complications during or imme- diately after the procedure, and number, size, location and characteristics of the lesions. Polyps or protruding lesions were defined as sessile or pedunculated, and nonprotruding lesions were defined according to Paris classification. For each lesion, histological diagnosis was recorded. RESULTS： Eight hundred and forty-nine colonosco- pies were carried with the standard white-light video colonoscope and 252 with the HD＋ plus i-Scan video colonoscope, The four endoscopists did 264, 300, 276 and 261 procedures, respectively; 21.6%, 24.0%, 21.7% and 24.1% of them with the HD＋ plus i-Scan technique. There were no significant differences be- tween the four endoscopists in either the number of procedures done or the proportions of each imaging technique used. Both techniques detected one or more mucosal lesions in 522/1101 procedures （47.4%）. The overall number of lesions recognized was 1266; 645 in the right colon and 621 in the left. A significantly higher number of colonoscopies recognized lesions in the HD＋ plus i-Scan mode （171/252 = 67.9%） than with the standard white-light technique （4
