Objective:To investigate the prevalence and risk factors of bronchial asthma in the Li ethnic group in Hainan,China.Methods:This study employed a stratified random sample design using custom-designed questionnaires.Su...Objective:To investigate the prevalence and risk factors of bronchial asthma in the Li ethnic group in Hainan,China.Methods:This study employed a stratified random sample design using custom-designed questionnaires.Subjects with asthma-like symptoms were first identified by two rounds of surveys and then confirmed by respiratory physicians using pulmonary function test,bronchial dilation test and challenge test.Demographic data,information on family history of asthma,history of allergies,smoking habits,domestic cooking fuel and other potential risk factors were collected.Logistic regression was performed to evaluate risk factors for asthma.Results: The prevalence of asthma in the Li ethnic group was 3.38%,much higher than the national average level in China.Aging,agriculture industry(the rubber industry in particular),rural residence,family history of asthma,history of allergies,cold air,inhalation of dust and irritant gases,smoking,domestic cooking fuel and living environment were associated with increased risk of asthma.Conclusions:The high prevalence of asthma in the Li ethnic group highlights the importance of asthma prevention and treatment in this population.Risk factors indentified in this study warrant special attention.Elevating public awareness about asthma in local communities will benefit the prevention of the disease.展开更多
Biomarkers indicate changes associated with disease. Blood is relatively stable due to the homeostatic mechanisms of the body;however, urine accumulates metabolites from changes in the body, making it a better source ...Biomarkers indicate changes associated with disease. Blood is relatively stable due to the homeostatic mechanisms of the body;however, urine accumulates metabolites from changes in the body, making it a better source for early biomarker discovery. The Li ethnic group is a unique minority ethnic group that has only lived on Hainan Island for approximately 5,000 years. Studies have shown that various specific genetic variations are different between the Li and Han ethnic groups. However, whether the urinary proteome between these two ethnic groups is significantly different remains unknown. In this study, differential urinary proteins were identified in the Li and Han ethnic groups using liquid chromatography tandem mass spectrometry(LC-MS/MS).In total, 1,555 urinary proteins were identified. Twenty-five of the urinary proteins were statistically significantly different, 16 of which have been previously reported to be biomarkers of many diseases, and that these significantly different proteins were caused by ethnic differences rather than random differences. Ethnic group differences may be an influencing factor in urine proteome studies and should be considered when human urine samples are used for biomarker discovery.展开更多
基金supported by Hainan Natural Science Fund (2002-203-30222)
文摘Objective:To investigate the prevalence and risk factors of bronchial asthma in the Li ethnic group in Hainan,China.Methods:This study employed a stratified random sample design using custom-designed questionnaires.Subjects with asthma-like symptoms were first identified by two rounds of surveys and then confirmed by respiratory physicians using pulmonary function test,bronchial dilation test and challenge test.Demographic data,information on family history of asthma,history of allergies,smoking habits,domestic cooking fuel and other potential risk factors were collected.Logistic regression was performed to evaluate risk factors for asthma.Results: The prevalence of asthma in the Li ethnic group was 3.38%,much higher than the national average level in China.Aging,agriculture industry(the rubber industry in particular),rural residence,family history of asthma,history of allergies,cold air,inhalation of dust and irritant gases,smoking,domestic cooking fuel and living environment were associated with increased risk of asthma.Conclusions:The high prevalence of asthma in the Li ethnic group highlights the importance of asthma prevention and treatment in this population.Risk factors indentified in this study warrant special attention.Elevating public awareness about asthma in local communities will benefit the prevention of the disease.
基金supported by the National Key Research and Development Program of China(2018YFC0910202,2016YFC1306300)Beijing Natural Science Foundation(7172076)+3 种基金the Key Basic Research Program of the Ministry of Science and Technology of China(2013FY114100)Beijing Cooperative Construction Project(110651103)Beijing Normal University(11100704)Peking Union Medical College Hospital(2016-2.27)
文摘Biomarkers indicate changes associated with disease. Blood is relatively stable due to the homeostatic mechanisms of the body;however, urine accumulates metabolites from changes in the body, making it a better source for early biomarker discovery. The Li ethnic group is a unique minority ethnic group that has only lived on Hainan Island for approximately 5,000 years. Studies have shown that various specific genetic variations are different between the Li and Han ethnic groups. However, whether the urinary proteome between these two ethnic groups is significantly different remains unknown. In this study, differential urinary proteins were identified in the Li and Han ethnic groups using liquid chromatography tandem mass spectrometry(LC-MS/MS).In total, 1,555 urinary proteins were identified. Twenty-five of the urinary proteins were statistically significantly different, 16 of which have been previously reported to be biomarkers of many diseases, and that these significantly different proteins were caused by ethnic differences rather than random differences. Ethnic group differences may be an influencing factor in urine proteome studies and should be considered when human urine samples are used for biomarker discovery.
