目的:探讨宫腔内人工授精(IUI)的最佳促排卵方案。方法:回顾性分析646个IUI周期,比较自然周期与促排卵周期、不同优势卵泡数目的促排卵周期、不同促排卵方案之间患者的临床妊娠率、多胎率、流产率的差异。结果:1促排卵周期人工授精临床...目的:探讨宫腔内人工授精(IUI)的最佳促排卵方案。方法:回顾性分析646个IUI周期,比较自然周期与促排卵周期、不同优势卵泡数目的促排卵周期、不同促排卵方案之间患者的临床妊娠率、多胎率、流产率的差异。结果:1促排卵周期人工授精临床妊娠率显著高于自然周期(20.84%vs 8.77%,P<0.05);2 h CG注射日优势卵泡数目1个、2个、3个之间的促排卵周期临床妊娠率分别为13.6%、24.14%、32.35%,差异有统计学意义(P<0.01);3氯米芬(CC)与CC联合尿促性腺激素(CC+h MG)2种促排卵方案相比,CC+h MG组与CC组比较,h CG注射日优势卵泡数(2.0±0.9 vs 1.5±0.3)、子宫内膜厚度(9.41±1.88 mm vs 8.06±1.92 mm)、妊娠率(22.13%vs 10.93%)差异均有统计学意义(P<0.05);来曲唑(LE)与LE+h MG 2种促排卵方案相比,LE+h MG组优势卵泡数显著大于LE组(1.6±0.7 vs 1.0±0.0,P<0.01),且临床妊娠率有增高的趋势。结论:各种促排卵方案能增加IUI临床妊娠率,CC或LE联合小剂量h MG的温和促排卵方案,能获得一个最为理想的临床结局。展开更多
目的:探讨精液处理后前向运动精子总数(post-wash total mobile sperm count,PTMC)对单纯以少、弱精子症为病因引起不孕不育症患者的夫精宫腔内人工授精(intrauterine insemination,IUI)妊娠率的影响。方法:分析2015年3月至2016年3月单...目的:探讨精液处理后前向运动精子总数(post-wash total mobile sperm count,PTMC)对单纯以少、弱精子症为病因引起不孕不育症患者的夫精宫腔内人工授精(intrauterine insemination,IUI)妊娠率的影响。方法:分析2015年3月至2016年3月单纯以少、弱精子症为适应症接受IUI治疗的125个周期的临床资料,按处理后前向运动精子数进行分组,A组19个周期:<10×10~6、B组71个周期:10×10~6~20×10~6、C组35个周期:>20×10~6,比较各组临床妊娠率。结果:周期总临床妊娠率15.20%,A组周期妊娠率10.53%,B组周期妊娠率16.90%,C组周期妊娠率14.29%,各组妊娠率比较差异无统计学意义(P>0.05)。结论:(1)由少、弱精子症引起不育的患者行IUI治疗,即使PTMC<10×10~6也能获得一定的妊娠率。(2)精液处理后前向运动精子数对IUI的妊娠率有一定影响,但妊娠率并非一定随着PTMC的增多而提高。展开更多
Objective To study the effect of timing and number of intrauterine insemination （IUI） per cycle on the outcome of artificial insemination by husband （AIH）. Methods A total of 195 infertile couples underwent 379 cy...Objective To study the effect of timing and number of intrauterine insemination （IUI） per cycle on the outcome of artificial insemination by husband （AIH）. Methods A total of 195 infertile couples underwent 379 cycles of lUI with husband＇s sperm. They were divided into 4 groups according to the ovulation and the number of IUIs per cycle： single IUI was performed 24 h after hCG injection, including single IUI before ovulation （group A） and single IUI after ovulation （group B）; double IUI was performed 24 h and 48 h after hCG injection, including double IUI before and after ovulation （group C） and double IUI before ovulation （group D）. The relation-ship between IUI pregnancy rate and the factors like processed total motile sperm （PTMS）, timing and number of lUIs per cycle was analyzed. Results When PTMS〈5 × 10^6, only one case in group B got pregnant, while no pregnancy was observed in other groups. When PTMS ≥ 5 × 10^6, pregnancy rates in all group were improved significantly. The pregnancy rate in group B reached 32.22%, which was significantly higher than that in group A （14.12%）, group C （20.00%） and group D （17.39%）, respectively （P〈0.05）. Conclusion IUI treatment is recommended to be performed when PTMS ≥ 5 × 10^6. An ideal pregnancy rate can be achieved by single IUI which is performed 24 h after hCG injection, and double IUI performed without ovulation could not result in significant improvement of cycle pregnancy rate.展开更多
文摘目的:探讨宫腔内人工授精(IUI)的最佳促排卵方案。方法:回顾性分析646个IUI周期,比较自然周期与促排卵周期、不同优势卵泡数目的促排卵周期、不同促排卵方案之间患者的临床妊娠率、多胎率、流产率的差异。结果:1促排卵周期人工授精临床妊娠率显著高于自然周期(20.84%vs 8.77%,P<0.05);2 h CG注射日优势卵泡数目1个、2个、3个之间的促排卵周期临床妊娠率分别为13.6%、24.14%、32.35%,差异有统计学意义(P<0.01);3氯米芬(CC)与CC联合尿促性腺激素(CC+h MG)2种促排卵方案相比,CC+h MG组与CC组比较,h CG注射日优势卵泡数(2.0±0.9 vs 1.5±0.3)、子宫内膜厚度(9.41±1.88 mm vs 8.06±1.92 mm)、妊娠率(22.13%vs 10.93%)差异均有统计学意义(P<0.05);来曲唑(LE)与LE+h MG 2种促排卵方案相比,LE+h MG组优势卵泡数显著大于LE组(1.6±0.7 vs 1.0±0.0,P<0.01),且临床妊娠率有增高的趋势。结论:各种促排卵方案能增加IUI临床妊娠率,CC或LE联合小剂量h MG的温和促排卵方案,能获得一个最为理想的临床结局。
文摘目的:探讨精液处理后前向运动精子总数(post-wash total mobile sperm count,PTMC)对单纯以少、弱精子症为病因引起不孕不育症患者的夫精宫腔内人工授精(intrauterine insemination,IUI)妊娠率的影响。方法:分析2015年3月至2016年3月单纯以少、弱精子症为适应症接受IUI治疗的125个周期的临床资料,按处理后前向运动精子数进行分组,A组19个周期:<10×10~6、B组71个周期:10×10~6~20×10~6、C组35个周期:>20×10~6,比较各组临床妊娠率。结果:周期总临床妊娠率15.20%,A组周期妊娠率10.53%,B组周期妊娠率16.90%,C组周期妊娠率14.29%,各组妊娠率比较差异无统计学意义(P>0.05)。结论:(1)由少、弱精子症引起不育的患者行IUI治疗,即使PTMC<10×10~6也能获得一定的妊娠率。(2)精液处理后前向运动精子数对IUI的妊娠率有一定影响,但妊娠率并非一定随着PTMC的增多而提高。
文摘Objective To study the effect of timing and number of intrauterine insemination （IUI） per cycle on the outcome of artificial insemination by husband （AIH）. Methods A total of 195 infertile couples underwent 379 cycles of lUI with husband＇s sperm. They were divided into 4 groups according to the ovulation and the number of IUIs per cycle： single IUI was performed 24 h after hCG injection, including single IUI before ovulation （group A） and single IUI after ovulation （group B）; double IUI was performed 24 h and 48 h after hCG injection, including double IUI before and after ovulation （group C） and double IUI before ovulation （group D）. The relation-ship between IUI pregnancy rate and the factors like processed total motile sperm （PTMS）, timing and number of lUIs per cycle was analyzed. Results When PTMS〈5 × 10^6, only one case in group B got pregnant, while no pregnancy was observed in other groups. When PTMS ≥ 5 × 10^6, pregnancy rates in all group were improved significantly. The pregnancy rate in group B reached 32.22%, which was significantly higher than that in group A （14.12%）, group C （20.00%） and group D （17.39%）, respectively （P〈0.05）. Conclusion IUI treatment is recommended to be performed when PTMS ≥ 5 × 10^6. An ideal pregnancy rate can be achieved by single IUI which is performed 24 h after hCG injection, and double IUI performed without ovulation could not result in significant improvement of cycle pregnancy rate.
