目的探讨家庭指导对青光眼术后患者眼压及生活质量的影响。方法将84例青光眼患者随机分为进行家庭指导的干预组和传统知识宣传的对照组,每组各42例。术后对患者眼压、生活质量(quality of life,QOL)进行测评。结果术后1年干预组患者的...目的探讨家庭指导对青光眼术后患者眼压及生活质量的影响。方法将84例青光眼患者随机分为进行家庭指导的干预组和传统知识宣传的对照组,每组各42例。术后对患者眼压、生活质量(quality of life,QOL)进行测评。结果术后1年干预组患者的眼压低于对照组,QOL各因子及总分高于对照组,两组比较,差异具有统计学意义(均P<0.05)。结论对青光眼术后患者进行家庭指导能有效控制青光眼患者的眼压和提高患者的生活质量。展开更多
●AIM:To assess effectivity and safety of trifocal intraocular lenses(IOLs)and capsular tension rings in treating cataract patients with axial high myopia.●METHODS:A prospective nonrandomized controlled clinical tria...●AIM:To assess effectivity and safety of trifocal intraocular lenses(IOLs)and capsular tension rings in treating cataract patients with axial high myopia.●METHODS:A prospective nonrandomized controlled clinical trial was conducted.Totally 98 eyes(74 patients)who underwent femtosecond laser-assisted cataract surgery(FLACS)with trifocal IOLs were enrolled in the study and followed up for 2y after surgery:46 eyes(33 patients)with capsular tension ring implantation in the long axial lengths(AL)group(26<AL<29 mm)and 52 eyes(41 patients)in the normal AL group(22<AL<24.5 mm).Postoperative outcomes about effectivity and safety,including the subjective and objective visual quality,and postoperative complications were assessed.●RESULTS:Uncorrected distance visual acuity at 5 m and uncorrected intermediate visual acuity at 60 and 80 cm in the long AL group were significantly worse than those in the normal AL group at 3mo postoperatively(P<0.05).The differences in reading speed,spectacle independence and potential visual complaints between the two groups were not statistically significant(P>0.05).The dysfunctional lens index and total modulation transfer function(MTF)average height were similar between the two groups.The postoperative internal coma aberrations in the axial high myopia eyes were significantly higher than that in the normal AL group(P<0.05).The total satisfaction score in the long AL group(91.32±2.76)was slightly higher than that in the normal AL group(90.36±3.47),but there was no difference(P=0.136).A statistically negative correlation was found between corrected distance visual acuity(CDVA)and dysfunctional lens index(r=-0.382,P=0.009),and between CDVA and the total MTF average height(r=-0.374,P=0.01).But there was no significant correlation between CDVA and total satisfaction score(r=0.059,P=0.696).Postoperative complications mainly presented as posterior capsular opacity(PCO),retinal detachment and cystoid macular edema.There was no difference in the incidence of fundus disease(6.5%vs 3.8%,P=0.663)展开更多
Objective To evaluate the variations of intraocular pressure （lOP） in suspected open-angle glaucoma （OAG） patients. Methods The variations of lOP were measured in 216 eyes of suspected OAG patients at 4-hour inter...Objective To evaluate the variations of intraocular pressure （lOP） in suspected open-angle glaucoma （OAG） patients. Methods The variations of lOP were measured in 216 eyes of suspected OAG patients at 4-hour intervals for 48 h. Based on the results of the serial lOP measurements, optic disc changed and visual field defected, the patients were diagnosed as primary OAG （ POAG ）, normal tension glaucoma （NTG）, ocular hypertension （ OHT） , or physiologic cup （PC）. Results After the serial lOP measurements, 16. 7% of the suspected OAG patients were diagnosed as POAG, 32. 4% as NTG, 24. 5% as OHT, and 26. 4% as PC. The highest percentages of the POAG group had peak lOP at 8 AM （19. 4% ） and their trough lOP at 10 PM （27. 8% ） ; the NTG group had peak lOP at 12 AM （18. 6% ） and their trough lOP at 12 PM （22. 9% ） ; the OHT group had peak lOP at 4 AM （22. 6% ） and their trough lOP at 10 PM （26. 4% ） ; and the PC group had peak lOP at 4 AM （ 21. 1% ） and their trough lOP at 12 PM （ 21. 1% ）. The percentages of peak lOP outside clinic （ 8 AM - 4 PM） in the POAG, NTG, OHT and PC groups were 55. 6%, 50. 0%, 58. 4% and 45. 7%, respectively. The mean magnitude of variance was 5. 1 - 6. 7 mmHg in those suspected OAG patients. There was a strong positive correlation in lOP between both eyes at each time point of measurement and the variation curves of the right and left eyes had parallel profiles in those suspected OAG patients. Conclusion Serial measurement of lOP is still needed, in order not to miss the peak and the trough lOP readings in suspected OAG patients, which helps in better management of glaucoma.展开更多
Background As intraocular pressure （lOP） and lOP fluctuation are known risk factors for glaucoma, it is important to understand the effects of high myopia on these ocular parameters. The aim of this study was to inv...Background As intraocular pressure （lOP） and lOP fluctuation are known risk factors for glaucoma, it is important to understand the effects of high myopia on these ocular parameters. The aim of this study was to investigate if primary open-angle glaucoma （POAG） patients with high myopia exhibit higher lOP and greater lOP fluctuations at resting conditions over 24 hours. Methods We designed a prospective control clinical study. Eighty-two eyes of 82 high-tension Chinese POAG patients only on prostaglandin analogue locally were divided into 3 groups according to various myopic grades （〈-6.0 D, n=27 and between -0.76 and -5.99 D, n=33） or without myopia （-0.75 to 0.75 D, n=22）. Single time lOP at 10 am, mean corrected 24-hour lOP, mean corrected night lOP, 24-hour lOP fluctuation and lOPs of 10 am, 2 pm, 6 pm, 10 pm, 2 am, 6 am and 8 am were measured. Results The lOP was higher in POAG patients with high myopia over those POAG alone in three ways： the elevated lOP value was 0.65 mmHg measured in single time lOP at 10 am, 0.84 mmHg in mean corrected 24-hour lOP, 0.97 mmHg in mean corrected night lOP. The 24-hour lOP fluctuation was lower in the two myopia groups than in non-myopia group. Further, using repeated measurement analysis of variance, there was no statistical significance among groups regarding the lOPs at the seven time points （P=0.77） and there was no interaction between groups and time points （P=0.71）, but the difference of lOPs at the seven time points in same group was statistically significant （P=0.01）. Conclusion High-tension POAG patients with high myopia, even on pharmacological glaucoma therapy, still have hinhe.r IC）P. h^Jt 24-hnur IC）P fluc.tuatinn at re.qtina ~.nnditinn.q wA.q InwAr in th~..~, n^ti~.nt.q展开更多
文摘目的探讨家庭指导对青光眼术后患者眼压及生活质量的影响。方法将84例青光眼患者随机分为进行家庭指导的干预组和传统知识宣传的对照组,每组各42例。术后对患者眼压、生活质量(quality of life,QOL)进行测评。结果术后1年干预组患者的眼压低于对照组,QOL各因子及总分高于对照组,两组比较,差异具有统计学意义(均P<0.05)。结论对青光眼术后患者进行家庭指导能有效控制青光眼患者的眼压和提高患者的生活质量。
文摘●AIM:To assess effectivity and safety of trifocal intraocular lenses(IOLs)and capsular tension rings in treating cataract patients with axial high myopia.●METHODS:A prospective nonrandomized controlled clinical trial was conducted.Totally 98 eyes(74 patients)who underwent femtosecond laser-assisted cataract surgery(FLACS)with trifocal IOLs were enrolled in the study and followed up for 2y after surgery:46 eyes(33 patients)with capsular tension ring implantation in the long axial lengths(AL)group(26<AL<29 mm)and 52 eyes(41 patients)in the normal AL group(22<AL<24.5 mm).Postoperative outcomes about effectivity and safety,including the subjective and objective visual quality,and postoperative complications were assessed.●RESULTS:Uncorrected distance visual acuity at 5 m and uncorrected intermediate visual acuity at 60 and 80 cm in the long AL group were significantly worse than those in the normal AL group at 3mo postoperatively(P<0.05).The differences in reading speed,spectacle independence and potential visual complaints between the two groups were not statistically significant(P>0.05).The dysfunctional lens index and total modulation transfer function(MTF)average height were similar between the two groups.The postoperative internal coma aberrations in the axial high myopia eyes were significantly higher than that in the normal AL group(P<0.05).The total satisfaction score in the long AL group(91.32±2.76)was slightly higher than that in the normal AL group(90.36±3.47),but there was no difference(P=0.136).A statistically negative correlation was found between corrected distance visual acuity(CDVA)and dysfunctional lens index(r=-0.382,P=0.009),and between CDVA and the total MTF average height(r=-0.374,P=0.01).But there was no significant correlation between CDVA and total satisfaction score(r=0.059,P=0.696).Postoperative complications mainly presented as posterior capsular opacity(PCO),retinal detachment and cystoid macular edema.There was no difference in the incidence of fundus disease(6.5%vs 3.8%,P=0.663)
文摘肾素血管紧张素系统(renin-angiotensin system,RAS),由数十种血管紧张素肽、肽酶和多种受体组成,特异性调节各组织器官功能,维持水电解质的稳态平衡。局部RAS组分广泛分布在人眼的组织结构中,并产生一系列生理及病理作用。文章就RAS系统的主要活性因子成分,及其如何维持原发性开角型青光眼(primary open angle glaucoma,POAG)小梁组织正常生理功能及房水正常动力学状态,以及其作为治疗青光眼的潜在药物靶点的前景进行综述。
文摘Objective To evaluate the variations of intraocular pressure （lOP） in suspected open-angle glaucoma （OAG） patients. Methods The variations of lOP were measured in 216 eyes of suspected OAG patients at 4-hour intervals for 48 h. Based on the results of the serial lOP measurements, optic disc changed and visual field defected, the patients were diagnosed as primary OAG （ POAG ）, normal tension glaucoma （NTG）, ocular hypertension （ OHT） , or physiologic cup （PC）. Results After the serial lOP measurements, 16. 7% of the suspected OAG patients were diagnosed as POAG, 32. 4% as NTG, 24. 5% as OHT, and 26. 4% as PC. The highest percentages of the POAG group had peak lOP at 8 AM （19. 4% ） and their trough lOP at 10 PM （27. 8% ） ; the NTG group had peak lOP at 12 AM （18. 6% ） and their trough lOP at 12 PM （22. 9% ） ; the OHT group had peak lOP at 4 AM （22. 6% ） and their trough lOP at 10 PM （26. 4% ） ; and the PC group had peak lOP at 4 AM （ 21. 1% ） and their trough lOP at 12 PM （ 21. 1% ）. The percentages of peak lOP outside clinic （ 8 AM - 4 PM） in the POAG, NTG, OHT and PC groups were 55. 6%, 50. 0%, 58. 4% and 45. 7%, respectively. The mean magnitude of variance was 5. 1 - 6. 7 mmHg in those suspected OAG patients. There was a strong positive correlation in lOP between both eyes at each time point of measurement and the variation curves of the right and left eyes had parallel profiles in those suspected OAG patients. Conclusion Serial measurement of lOP is still needed, in order not to miss the peak and the trough lOP readings in suspected OAG patients, which helps in better management of glaucoma.
文摘Background As intraocular pressure （lOP） and lOP fluctuation are known risk factors for glaucoma, it is important to understand the effects of high myopia on these ocular parameters. The aim of this study was to investigate if primary open-angle glaucoma （POAG） patients with high myopia exhibit higher lOP and greater lOP fluctuations at resting conditions over 24 hours. Methods We designed a prospective control clinical study. Eighty-two eyes of 82 high-tension Chinese POAG patients only on prostaglandin analogue locally were divided into 3 groups according to various myopic grades （〈-6.0 D, n=27 and between -0.76 and -5.99 D, n=33） or without myopia （-0.75 to 0.75 D, n=22）. Single time lOP at 10 am, mean corrected 24-hour lOP, mean corrected night lOP, 24-hour lOP fluctuation and lOPs of 10 am, 2 pm, 6 pm, 10 pm, 2 am, 6 am and 8 am were measured. Results The lOP was higher in POAG patients with high myopia over those POAG alone in three ways： the elevated lOP value was 0.65 mmHg measured in single time lOP at 10 am, 0.84 mmHg in mean corrected 24-hour lOP, 0.97 mmHg in mean corrected night lOP. The 24-hour lOP fluctuation was lower in the two myopia groups than in non-myopia group. Further, using repeated measurement analysis of variance, there was no statistical significance among groups regarding the lOPs at the seven time points （P=0.77） and there was no interaction between groups and time points （P=0.71）, but the difference of lOPs at the seven time points in same group was statistically significant （P=0.01）. Conclusion High-tension POAG patients with high myopia, even on pharmacological glaucoma therapy, still have hinhe.r IC）P. h^Jt 24-hnur IC）P fluc.tuatinn at re.qtina ~.nnditinn.q wA.q InwAr in th~..~, n^ti~.nt.q
