Background Previous studies have demonstrated that serum uric acid （UA） is an independent predictor of incident type 2 diabetes mellitus （T2DM） in general populations. This study aimed to investigate specific char...Background Previous studies have demonstrated that serum uric acid （UA） is an independent predictor of incident type 2 diabetes mellitus （T2DM） in general populations. This study aimed to investigate specific characteristics of UA and its relationship between UA and blood glucose and other risk factors in the Chinese population.Methods A total of 946 subjects were included in this study. UA, glucose, insulin, fractional excretion of UA （FEua）,creatinine clearance rate （Ccr）, hemoglobin A1c （HbA1c）, fructosamine （FA）, blood pressure and lipids were studied and also reexamined after the patients underwent two weeks of combined therapeutics.Results UA levels were the highest in subjects with impaired glucose regulation （IGR）, followed by subjects with normoglycemia （NGT） and finally by subjects with T2DM. The level of the 2-hour postprandial insulin and the area under the curve for insulin （AUCins） showed a similar tendency. The UA levels initially increased with increasing fasting blood glucose （FBG） and postprandial blood glucose （PPBG） levels, up to 7 mmol/L and 10 mmol/L, respectively, and thereafter decreased at higher FBG and PPBG levels. Compared with subjects in the lower serum UA quartile, subjects in the upper quartile of serum UA levels had higher weights, triglyceride levels, and creatinine levels as well as lower Ccr and FEua levels. Compared with women＇s group, UA levels were higher, and FEua levels were lower in men＇s group. Sex,body mass index （BMI）, mean arterial blood pressure （MAP）, serum triglycerides （TG）, FA and Ccr were independent correlation factors of UA. UA decreased and FEua increased after the patients underwent a combined treatment.Conclusions UA increased initially and then decreased as glucose levels increased from NGT to IGR and T2DM.Compared with NGT and T2DM, IGR subjects had higher SUA levels, which related to its high levels of insulin. Under T2DM, male gender, BMI, MAP, Ccr, TG and FA are independent correlation factors展开更多
目的探讨胰岛素强化治疗对初诊断为2型糖尿病(T2DM)的患者尿白蛋白排泄率(UAER)、糖化血红蛋白(HbAlc)及血脂水平的影响。方法选取内分泌科治疗的82例初诊断为T2DM的患者,采用随机方法将其分为对照组与强化组,每组41例。对照组口服药物...目的探讨胰岛素强化治疗对初诊断为2型糖尿病(T2DM)的患者尿白蛋白排泄率(UAER)、糖化血红蛋白(HbAlc)及血脂水平的影响。方法选取内分泌科治疗的82例初诊断为T2DM的患者,采用随机方法将其分为对照组与强化组,每组41例。对照组口服药物治疗,强化组胰岛素强化治疗,8周后比较两组患者的疗效指标。结果治疗后,两组患者FPG、2 h PG、HbAlc水平低于治疗前(P<0.05),且强化组低于对照组,差异有统计学意义(P<0.05)。两组TG、TC及UAER水平治疗后较治疗前降低(P<0.05),强化组UAER水平低于对照组(P<0.05),两组TG、TC水平比较,差异未见统计学意义(P>0.05)。结论胰岛素强化治疗初诊T2DM能有效改善患者UAER、HbAlc、血脂水平,降低血糖,减轻胰岛素抵抗,延缓病情向糖尿病肾病进展,推荐临床使用。展开更多
文摘Background Previous studies have demonstrated that serum uric acid （UA） is an independent predictor of incident type 2 diabetes mellitus （T2DM） in general populations. This study aimed to investigate specific characteristics of UA and its relationship between UA and blood glucose and other risk factors in the Chinese population.Methods A total of 946 subjects were included in this study. UA, glucose, insulin, fractional excretion of UA （FEua）,creatinine clearance rate （Ccr）, hemoglobin A1c （HbA1c）, fructosamine （FA）, blood pressure and lipids were studied and also reexamined after the patients underwent two weeks of combined therapeutics.Results UA levels were the highest in subjects with impaired glucose regulation （IGR）, followed by subjects with normoglycemia （NGT） and finally by subjects with T2DM. The level of the 2-hour postprandial insulin and the area under the curve for insulin （AUCins） showed a similar tendency. The UA levels initially increased with increasing fasting blood glucose （FBG） and postprandial blood glucose （PPBG） levels, up to 7 mmol/L and 10 mmol/L, respectively, and thereafter decreased at higher FBG and PPBG levels. Compared with subjects in the lower serum UA quartile, subjects in the upper quartile of serum UA levels had higher weights, triglyceride levels, and creatinine levels as well as lower Ccr and FEua levels. Compared with women＇s group, UA levels were higher, and FEua levels were lower in men＇s group. Sex,body mass index （BMI）, mean arterial blood pressure （MAP）, serum triglycerides （TG）, FA and Ccr were independent correlation factors of UA. UA decreased and FEua increased after the patients underwent a combined treatment.Conclusions UA increased initially and then decreased as glucose levels increased from NGT to IGR and T2DM.Compared with NGT and T2DM, IGR subjects had higher SUA levels, which related to its high levels of insulin. Under T2DM, male gender, BMI, MAP, Ccr, TG and FA are independent correlation factors
文摘目的探讨胰岛素强化治疗对初诊断为2型糖尿病(T2DM)的患者尿白蛋白排泄率(UAER)、糖化血红蛋白(HbAlc)及血脂水平的影响。方法选取内分泌科治疗的82例初诊断为T2DM的患者,采用随机方法将其分为对照组与强化组,每组41例。对照组口服药物治疗,强化组胰岛素强化治疗,8周后比较两组患者的疗效指标。结果治疗后,两组患者FPG、2 h PG、HbAlc水平低于治疗前(P<0.05),且强化组低于对照组,差异有统计学意义(P<0.05)。两组TG、TC及UAER水平治疗后较治疗前降低(P<0.05),强化组UAER水平低于对照组(P<0.05),两组TG、TC水平比较,差异未见统计学意义(P>0.05)。结论胰岛素强化治疗初诊T2DM能有效改善患者UAER、HbAlc、血脂水平,降低血糖,减轻胰岛素抵抗,延缓病情向糖尿病肾病进展,推荐临床使用。
