Pseudorabies(PR),also called Aujeszky's disease,is a highly infectious disease caused by pseudorabies virus(PRV).Without specific host tropism,PRV can infect a wide variety of mammals,including pig,sheep,cattle,et...Pseudorabies(PR),also called Aujeszky's disease,is a highly infectious disease caused by pseudorabies virus(PRV).Without specific host tropism,PRV can infect a wide variety of mammals,including pig,sheep,cattle,etc.,thereby causing severe clinical symptoms and acute death.PRV was firstly reported in China in 1950s,while outbreaks of emerging PRV variants have been documented in partial regions since 2011,leading to significant economic losses in swine industry.Although scientists have been devoting to the design of diagnostic approaches and the development of vaccines during the past years,PR remains a vital infectious disease widely prevalent in Chinese pig industry.Especially,its potential threat to human health has also attracted the worldwide attention.In this review,we will provide a summary of current understanding of PRV in China,mainly focusing on PRV history,the existing diagnosis methods,PRV prevalence in pig population and other susceptible mammals,molecular characteristics,and the available vaccines against its infection.Additionally,promising agents including traditional Chinese herbal medicines and novel inhibitors that may be employed to treat this viral infection,are also discussed.展开更多
目的了解医院感染发病率及危险因素,以改进医院感染发病率监测方法与医院感染预防控制措施。方法医院感染专职人员与临床医院感染管理小组人员共同调查前1 d 0∶00至当日0∶00所有住院患者,查阅病历和床旁调查相结合,填写统一的现患率...目的了解医院感染发病率及危险因素,以改进医院感染发病率监测方法与医院感染预防控制措施。方法医院感染专职人员与临床医院感染管理小组人员共同调查前1 d 0∶00至当日0∶00所有住院患者,查阅病历和床旁调查相结合,填写统一的现患率调查表和医院感染个案登记表,对调查结果进行统计分析。结果应调查住院患者208例,实际调查208例,实查率:100.00%;医院感染现患率为2.88%,感染部位均为呼吸道,危险因素主要包括气管插管、气管切开。结论根据结果有针对性地开展目标监测和采取防控措施,不断降低医院感染率。展开更多
基金This work was supported by the General Program of National Natural Science Foundation of China(Grants No.31571432/31802252)the Hunan Provincial Natural Science Foundation of China(Grant No.2015JC3097/2020JJ4041)the Postgraduate Scientific Research Innovation Project of Hunan Province(CX20200659).
文摘Pseudorabies(PR),also called Aujeszky's disease,is a highly infectious disease caused by pseudorabies virus(PRV).Without specific host tropism,PRV can infect a wide variety of mammals,including pig,sheep,cattle,etc.,thereby causing severe clinical symptoms and acute death.PRV was firstly reported in China in 1950s,while outbreaks of emerging PRV variants have been documented in partial regions since 2011,leading to significant economic losses in swine industry.Although scientists have been devoting to the design of diagnostic approaches and the development of vaccines during the past years,PR remains a vital infectious disease widely prevalent in Chinese pig industry.Especially,its potential threat to human health has also attracted the worldwide attention.In this review,we will provide a summary of current understanding of PRV in China,mainly focusing on PRV history,the existing diagnosis methods,PRV prevalence in pig population and other susceptible mammals,molecular characteristics,and the available vaccines against its infection.Additionally,promising agents including traditional Chinese herbal medicines and novel inhibitors that may be employed to treat this viral infection,are also discussed.
文摘目的了解医院感染发病率及危险因素,以改进医院感染发病率监测方法与医院感染预防控制措施。方法医院感染专职人员与临床医院感染管理小组人员共同调查前1 d 0∶00至当日0∶00所有住院患者,查阅病历和床旁调查相结合,填写统一的现患率调查表和医院感染个案登记表,对调查结果进行统计分析。结果应调查住院患者208例,实际调查208例,实查率:100.00%;医院感染现患率为2.88%,感染部位均为呼吸道,危险因素主要包括气管插管、气管切开。结论根据结果有针对性地开展目标监测和采取防控措施,不断降低医院感染率。
