目的探讨肝移植患者术后免疫抑制剂治疗不良反应经历及困扰程度对生存质量的影响。方法采用36题健康状况调查问卷(Short Form 36 Health Survey,SF-36)及移植症状发生和症状困扰量表(Modified Transplant Symptom Occurrenceand Symptom...目的探讨肝移植患者术后免疫抑制剂治疗不良反应经历及困扰程度对生存质量的影响。方法采用36题健康状况调查问卷(Short Form 36 Health Survey,SF-36)及移植症状发生和症状困扰量表(Modified Transplant Symptom Occurrenceand Symptom Distress Scale-59 Revised,MTSOSD-59R)对154例肝移植患者进行问卷调查。结果免疫抑制剂不良反应发生频率和症状困扰程度都处于中等以下水平,不良反应经历为躯体健康相关生存质量最强影响因子,而症状困扰为心理健康相关生存质量最强影响因子。此外,术后并发症、工作情况、年龄和家庭收入也对术后生存质量有预测作用。结论肝移植患者术后均会出现不同程度免疫抑制剂的不良反应,其症状发生和困扰程度较轻且对肝移植患者术后的生存质量有影响。展开更多
A series of amino alcohol derivatives containing coumarin and benzothiophene moieties was synthesized with 5-bromosalicylaldehyde and 5-bromo-2-thiophenecarboxaldehyde as starting materials, 6-substituted-3-chromanone...A series of amino alcohol derivatives containing coumarin and benzothiophene moieties was synthesized with 5-bromosalicylaldehyde and 5-bromo-2-thiophenecarboxaldehyde as starting materials, 6-substituted-3-chromanone and 4,5-dihydrobenzo[b]-thiophen-5（4H）-one as intermediates and Suzuki reaction and spiro-hydantoin hydrolysis as key steps. The structures of key intermediate and target compounds were confirmed by ^1H NMR, ^13C NMR IR and HRMS. Their characterization as sphirtgosine 1-phosphate（S 1P） receptor agonists was reported.展开更多
文摘A series of amino alcohol derivatives containing coumarin and benzothiophene moieties was synthesized with 5-bromosalicylaldehyde and 5-bromo-2-thiophenecarboxaldehyde as starting materials, 6-substituted-3-chromanone and 4,5-dihydrobenzo[b]-thiophen-5（4H）-one as intermediates and Suzuki reaction and spiro-hydantoin hydrolysis as key steps. The structures of key intermediate and target compounds were confirmed by ^1H NMR, ^13C NMR IR and HRMS. Their characterization as sphirtgosine 1-phosphate（S 1P） receptor agonists was reported.
