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Dynamic Wnt5a expression in murine hair follicle cycle and its inhibitory effects on follicular in vivo 被引量:2
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作者 De-Ren Fang Zhong-Fa Lv Gang Qiao 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2014年第4期285-288,共4页
Objective:To analyze the dynamic expression of Wnt family member 5A(Wingless-type MMTV integration Wnt site family,member 5a)in murine hair cycle and its inhibitory effects on follicle in vivo.Methods:Situ hybridizati... Objective:To analyze the dynamic expression of Wnt family member 5A(Wingless-type MMTV integration Wnt site family,member 5a)in murine hair cycle and its inhibitory effects on follicle in vivo.Methods:Situ hybridization in full-thickness skin was used to observe the change of mouse protein expression in different growth stages,and Ad-Wnt5a was injected after defeathering to observe the hair follicle growth in vivo.Results:The Wnt5a mRNA was expressed at birth,and was firstly increased then decreased along with the progress of the hair cycle.It reached the peak in advanced stage of growth cycle(P<0.05).Rhoa andβ-catenin expression levels were significantly decreased in three groups.Rac2 expression was significantly up-regulated,and the expression level of Wnt5a,Shh and Frizzled2 was increased,but less significantly than group 2.Conclusions:The expression of Wnt5a mRNA is consistent with change of murine follicle cycle,and has obvious inhibitory effects on the growth of hair follicle in vivo,indicating that it is antagonistic to Wnts pathway and interferes the growth of follicle together. 展开更多
关键词 WNT5A HAIR follicle cycle iinhibition PROLIFERATION
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聚乙烯绝缘中空间电荷的抑制方法及原理 被引量:2
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作者 仇斌 陈文卿 屠德民 《电线电缆》 2011年第4期23-27,共5页
随着我国经济的高速发展,研制高压直流XLPE电力电缆已提到日程,目前迫切的任务是研发直流XLPE电缆料,研发的关键在于消除或抑制XLPE中的空间电荷。文中在介绍国内外抑制聚乙烯绝缘中空间电荷方法的基础上,讨论抑制空间电荷的原理。
关键词 聚乙烯 直流绝缘 空间电荷 抑制方法 原理
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