The dynamical framework of the nine-level version of the IAP AGCM is presented in this paper. The emphasis of the model's description is put on the following two aspects:(1) A model's standard atmosphere, whic...The dynamical framework of the nine-level version of the IAP AGCM is presented in this paper. The emphasis of the model's description is put on the following two aspects:(1) A model's standard atmosphere, which is a satisfactory approximation to the observed troposphere and lower stratosphere standard atmosphere, is introduced into the equations of the model to permit a more accurate calculation of the vertical transport terms, especially near the tropopause; (2) The vertical levels of the model are carefully selected to guarantee a smooth dependence of layer thickness upon pressure in order to reduce the truncation error involved in the unequal interval vertical finite-differencing. For testing the model, two kinds of linear baroclinic Rossby-Haurwitz waves, one of which has a dynamically stable vertical structure and the other has a relatively unstable one, are constructed to provide initial conditions for numerical experiments. The two waves have been integrated for more than 300 days and 100 days respectively by using the model and both of them are propagating westward with almost identical phase-speed during the time period of the integrations. No obvious change of the wave patterns is found at the levels in the model's troposphere. The amplitudes of both two waves at the uppermost level, however, exhibit rather significant oscillation with time, of which the periods are exactly 20 days and 25 days espectively.The explanation of this interesting phenomena is still under investigation.展开更多
IAPs (inhibitors of apoptosis) are a family of proteins containing one or more characteristic BIR domains. These proteins have multiple biological activities that include binding and inhibiting caspases, regulating ce...IAPs (inhibitors of apoptosis) are a family of proteins containing one or more characteristic BIR domains. These proteins have multiple biological activities that include binding and inhibiting caspases, regulating cell cycle progression, and modulating receptor-mediated signal transduction. Our recent studies found the IAP family members XIAP and c-IAP1 are ubiquitinated and degraded in proteasomes in response to apoptotic stimuli in T cells, and their degradation appears to be important for T cells to commit to death. In addition to three BIR domains, each of these IAPs also contains a RING finger domain.We found this region confers ubiquitin protease ligase (E3) activity to IAPs, and is responsible for the auto-ubiquitination and degradation of IAPs after an apoptotic stimulus. Given the factthat IAPs can bind a variety of proteins, such as caspases and TRAFs, it will be of interest to characterize potential substrates of the E3 activity of IAPs and the effects of ubiquitination byIAPs on signal transduction, cell cycle, and apoptosis.展开更多
文摘The dynamical framework of the nine-level version of the IAP AGCM is presented in this paper. The emphasis of the model's description is put on the following two aspects:(1) A model's standard atmosphere, which is a satisfactory approximation to the observed troposphere and lower stratosphere standard atmosphere, is introduced into the equations of the model to permit a more accurate calculation of the vertical transport terms, especially near the tropopause; (2) The vertical levels of the model are carefully selected to guarantee a smooth dependence of layer thickness upon pressure in order to reduce the truncation error involved in the unequal interval vertical finite-differencing. For testing the model, two kinds of linear baroclinic Rossby-Haurwitz waves, one of which has a dynamically stable vertical structure and the other has a relatively unstable one, are constructed to provide initial conditions for numerical experiments. The two waves have been integrated for more than 300 days and 100 days respectively by using the model and both of them are propagating westward with almost identical phase-speed during the time period of the integrations. No obvious change of the wave patterns is found at the levels in the model's troposphere. The amplitudes of both two waves at the uppermost level, however, exhibit rather significant oscillation with time, of which the periods are exactly 20 days and 25 days espectively.The explanation of this interesting phenomena is still under investigation.
文摘IAPs (inhibitors of apoptosis) are a family of proteins containing one or more characteristic BIR domains. These proteins have multiple biological activities that include binding and inhibiting caspases, regulating cell cycle progression, and modulating receptor-mediated signal transduction. Our recent studies found the IAP family members XIAP and c-IAP1 are ubiquitinated and degraded in proteasomes in response to apoptotic stimuli in T cells, and their degradation appears to be important for T cells to commit to death. In addition to three BIR domains, each of these IAPs also contains a RING finger domain.We found this region confers ubiquitin protease ligase (E3) activity to IAPs, and is responsible for the auto-ubiquitination and degradation of IAPs after an apoptotic stimulus. Given the factthat IAPs can bind a variety of proteins, such as caspases and TRAFs, it will be of interest to characterize potential substrates of the E3 activity of IAPs and the effects of ubiquitination byIAPs on signal transduction, cell cycle, and apoptosis.
