AIM To investigate the relationship between coronary calcium score(CCS) and vulnerable plaque/significant stenosis using coronary computed tomographic angiography(CCTA). METHODS CCTA was performed in 651 patients and ...AIM To investigate the relationship between coronary calcium score(CCS) and vulnerable plaque/significant stenosis using coronary computed tomographic angiography(CCTA). METHODS CCTA was performed in 651 patients and these patients were divided into the four groups(CCS 0, 1-100, 101-400 and > 400). We studied the incidence of high-risk plaque, including positive remodeling, low attenuation plaque, spotty calcification, and napkin-ring sign, and significant stenosis in each group. RESULTS High-risk plaque was found in 1.3%, 10.1%, 13.3% and 13.4% of patients with CCS 0, 1-100, 101-400 and > 400, respectively(P < 0.001). The difference was only significant for patients with zero CCS. The incidence of significant stenosis was 0.6%, 7.6%, 13.3% and 26.9% for each patient group, respectively(P < 0.001), which represented a significant stepwise increase as CCS increased. The combined incidence of high-risk plaque and significant stenosis was 1.9%, 17.7%, 26.9% and 40.3% in each patient group, respectively(P < 0.001), again representing a significant stepwise increase with CCS. The rate of major coronary event was 0%, 4.0%, 7.9% and 17.2% in each patient group, respectively(P < 0.001), another significant stepwise increase as CCS increased. CONCLUSION Stepwise increased risk of coronary events associated with increasing CCS is caused by increasing incidence of significant stenosis, while that of high-risk plaque remains the same.展开更多
目的探讨大血小板比率(the rate of large platelets,PLCR)及脑卒中危险因素在高危脑卒中患者的动脉斑块病变中的影响。方法回顾性研究2016年-2018年在余姚人民医院就诊的脑卒中高危患者,根据彩色多普勒超声诊断仪检查颈动脉粥样斑块的...目的探讨大血小板比率(the rate of large platelets,PLCR)及脑卒中危险因素在高危脑卒中患者的动脉斑块病变中的影响。方法回顾性研究2016年-2018年在余姚人民医院就诊的脑卒中高危患者,根据彩色多普勒超声诊断仪检查颈动脉粥样斑块的数量,同时采用全自动生化分析仪检测患者血脂、血糖等相关生化指标以及用血细胞分析仪测定血小板相关参数包括血小板数量(platelet,PLT)、血小板平均体积(mean platelet volume,MVP)、PLCR等指标,并按照PLCR水平为3组。结果 PLCR是脑卒中高危患者动脉斑块病变的独立危险因素(OR=1.110,95%CI:1.031~1.195,P=0.006)。PLCR高水平组合并脑卒中危险因素的颈动脉斑块的形成率均高于PLCR低水平和中水平合并脑卒中危险因素组(P<0.05)。结论脑卒中高危人群大血小板比率的水平与动脉斑块密切相关,尤其在合并脑卒中相关危险因素后将进一步影响动脉斑块的形成。展开更多
文摘AIM To investigate the relationship between coronary calcium score(CCS) and vulnerable plaque/significant stenosis using coronary computed tomographic angiography(CCTA). METHODS CCTA was performed in 651 patients and these patients were divided into the four groups(CCS 0, 1-100, 101-400 and > 400). We studied the incidence of high-risk plaque, including positive remodeling, low attenuation plaque, spotty calcification, and napkin-ring sign, and significant stenosis in each group. RESULTS High-risk plaque was found in 1.3%, 10.1%, 13.3% and 13.4% of patients with CCS 0, 1-100, 101-400 and > 400, respectively(P < 0.001). The difference was only significant for patients with zero CCS. The incidence of significant stenosis was 0.6%, 7.6%, 13.3% and 26.9% for each patient group, respectively(P < 0.001), which represented a significant stepwise increase as CCS increased. The combined incidence of high-risk plaque and significant stenosis was 1.9%, 17.7%, 26.9% and 40.3% in each patient group, respectively(P < 0.001), again representing a significant stepwise increase with CCS. The rate of major coronary event was 0%, 4.0%, 7.9% and 17.2% in each patient group, respectively(P < 0.001), another significant stepwise increase as CCS increased. CONCLUSION Stepwise increased risk of coronary events associated with increasing CCS is caused by increasing incidence of significant stenosis, while that of high-risk plaque remains the same.
文摘目的探讨大血小板比率(the rate of large platelets,PLCR)及脑卒中危险因素在高危脑卒中患者的动脉斑块病变中的影响。方法回顾性研究2016年-2018年在余姚人民医院就诊的脑卒中高危患者,根据彩色多普勒超声诊断仪检查颈动脉粥样斑块的数量,同时采用全自动生化分析仪检测患者血脂、血糖等相关生化指标以及用血细胞分析仪测定血小板相关参数包括血小板数量(platelet,PLT)、血小板平均体积(mean platelet volume,MVP)、PLCR等指标,并按照PLCR水平为3组。结果 PLCR是脑卒中高危患者动脉斑块病变的独立危险因素(OR=1.110,95%CI:1.031~1.195,P=0.006)。PLCR高水平组合并脑卒中危险因素的颈动脉斑块的形成率均高于PLCR低水平和中水平合并脑卒中危险因素组(P<0.05)。结论脑卒中高危人群大血小板比率的水平与动脉斑块密切相关,尤其在合并脑卒中相关危险因素后将进一步影响动脉斑块的形成。
