Cholangiocarcinoma(CCA) is a malignant tumour that arises from biliary epithelium at any portion of the biliary tree.CCA is currently classified as intra-hepatic or extra-hepatic CCA(EH-CCA).Recent evidences suggest t...Cholangiocarcinoma(CCA) is a malignant tumour that arises from biliary epithelium at any portion of the biliary tree.CCA is currently classified as intra-hepatic or extra-hepatic CCA(EH-CCA).Recent evidences suggest that intra-hepatic CCA(IH-CCA) and EH-CCA are biologically different cancers,giving further support to a number of recent epidemiological studies showing large differences in terms of incidence,mortality and risk factors.The purpose of this manuscript is to review recent literature dealing with the descriptive epidemiology and risk factors of CCA with a special effort to compare IH-with EH-CCA.展开更多
目的探讨肝外胆管癌(extra-hepatic cholangiocarcinoma,ECC)的预后影响因素,并建立有效的列线图生存预测模型。方法收集SEER(Surveillance,Epidemiology,and End Results)数据库中2004—2015年诊断为ECC的患者临床资料,进行回顾性分析...目的探讨肝外胆管癌(extra-hepatic cholangiocarcinoma,ECC)的预后影响因素,并建立有效的列线图生存预测模型。方法收集SEER(Surveillance,Epidemiology,and End Results)数据库中2004—2015年诊断为ECC的患者临床资料,进行回顾性分析,采用SPSS软件对可能与预后相关的变量进行Cox回归分析,筛选出独立预后因素。使用R语言绘制ECC预后预测列线图模型,并采用C-index和校准曲线验证其准确性。结果共纳入3102例ECC患者。Cox分析显示,年龄、T分期、淋巴结转移、远处转移、肿瘤大小、手术治疗、化疗以及婚姻状态是ECC患者的独立预后因素。列线图模型校准曲线与理想曲线一致性较高,C-index为0.713,1、3、5年患者生存时间ROC曲线下面积分别为0.752、0.784、0.778。结论年龄、T分期、淋巴结转移、远处转移、肿瘤大小、手术治疗、化疗以及婚姻状态是ECC患者的独立预后因素,以此建立的列线图模型对ECC患者预后有一定的预测价值。展开更多
文摘Cholangiocarcinoma(CCA) is a malignant tumour that arises from biliary epithelium at any portion of the biliary tree.CCA is currently classified as intra-hepatic or extra-hepatic CCA(EH-CCA).Recent evidences suggest that intra-hepatic CCA(IH-CCA) and EH-CCA are biologically different cancers,giving further support to a number of recent epidemiological studies showing large differences in terms of incidence,mortality and risk factors.The purpose of this manuscript is to review recent literature dealing with the descriptive epidemiology and risk factors of CCA with a special effort to compare IH-with EH-CCA.
文摘目的探讨肝外胆管癌(extra-hepatic cholangiocarcinoma,ECC)的预后影响因素,并建立有效的列线图生存预测模型。方法收集SEER(Surveillance,Epidemiology,and End Results)数据库中2004—2015年诊断为ECC的患者临床资料,进行回顾性分析,采用SPSS软件对可能与预后相关的变量进行Cox回归分析,筛选出独立预后因素。使用R语言绘制ECC预后预测列线图模型,并采用C-index和校准曲线验证其准确性。结果共纳入3102例ECC患者。Cox分析显示,年龄、T分期、淋巴结转移、远处转移、肿瘤大小、手术治疗、化疗以及婚姻状态是ECC患者的独立预后因素。列线图模型校准曲线与理想曲线一致性较高,C-index为0.713,1、3、5年患者生存时间ROC曲线下面积分别为0.752、0.784、0.778。结论年龄、T分期、淋巴结转移、远处转移、肿瘤大小、手术治疗、化疗以及婚姻状态是ECC患者的独立预后因素,以此建立的列线图模型对ECC患者预后有一定的预测价值。
