BACKGROUND： The prognostic prediction of liver transplantation（LT） guides the donor organ allocation. However, there is currently no satisfactory model to predict the recipients’ outcome, especially for the patien...BACKGROUND： The prognostic prediction of liver transplantation（LT） guides the donor organ allocation. However, there is currently no satisfactory model to predict the recipients’ outcome, especially for the patients with HBV cirrhosis-related hepatocellular carcinoma（HCC）. The present study was to develop a quantitative assessment model for predicting the post-LT survival in HBV-related HCC patients.METHODS： Two hundred and thirty-eight LT recipients at the Liver Transplant Center, First Affiliated Hospital, Zhejiang University School of Medicine between 2008 and 2013 were included in this study. Their post-LT prognosis was recorded and multiple risk factors were analyzed using univariate and multivariate analyses in Cox regression.RESULTS： The score model was as follows： 0.114×（Child-Pugh score）-0.002×（positive HBV DNA detection time）＋0.647×（number of tumor nodules）＋0.055×（max diameter of tumor nodules）＋0.231×ln AFP＋0.437×（tumor differentiation grade）.The receiver operating characteristic curve analysis showed that the area under the curve of the scoring model for predicting the post-LT survival was 0.887. The cut-off value was 1.27, which was associated with a sensitivity of 72.5% and a specificity of 90.7%, respectively.CONCLUSION： The quantitative score model for predicting post-LT survival proved to be sensitive and specific.展开更多
1 背景
慢性乙型肝炎病毒（hepatitis B virus,HBV）感染是肝硬化的重要原因。研究显示，有效抑制HBV复制可改善肝纤维化^[1-2]，延缓或阻止代偿期肝硬化向失代偿期的进展，减少失代偿期患者病情进一步恶化，减少门静脉高压及相关并发...1 背景
慢性乙型肝炎病毒（hepatitis B virus,HBV）感染是肝硬化的重要原因。研究显示，有效抑制HBV复制可改善肝纤维化^[1-2]，延缓或阻止代偿期肝硬化向失代偿期的进展，减少失代偿期患者病情进一步恶化，减少门静脉高压及相关并发症发生^[3-6]，延长生存期^[3-4]。因此，有效的抗病毒治疗对改善疾病临床结局具有重要意义^[7]，也是目前HBV相关肝硬化整体治疗策略中的一个重要组成部分。展开更多
基金supported by grants from National S&T Major Project(2012ZX10002017)the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(81121002)the National Natural Science Foundation of China(81200331)
文摘BACKGROUND： The prognostic prediction of liver transplantation（LT） guides the donor organ allocation. However, there is currently no satisfactory model to predict the recipients’ outcome, especially for the patients with HBV cirrhosis-related hepatocellular carcinoma（HCC）. The present study was to develop a quantitative assessment model for predicting the post-LT survival in HBV-related HCC patients.METHODS： Two hundred and thirty-eight LT recipients at the Liver Transplant Center, First Affiliated Hospital, Zhejiang University School of Medicine between 2008 and 2013 were included in this study. Their post-LT prognosis was recorded and multiple risk factors were analyzed using univariate and multivariate analyses in Cox regression.RESULTS： The score model was as follows： 0.114×（Child-Pugh score）-0.002×（positive HBV DNA detection time）＋0.647×（number of tumor nodules）＋0.055×（max diameter of tumor nodules）＋0.231×ln AFP＋0.437×（tumor differentiation grade）.The receiver operating characteristic curve analysis showed that the area under the curve of the scoring model for predicting the post-LT survival was 0.887. The cut-off value was 1.27, which was associated with a sensitivity of 72.5% and a specificity of 90.7%, respectively.CONCLUSION： The quantitative score model for predicting post-LT survival proved to be sensitive and specific.
文摘1 背景
慢性乙型肝炎病毒（hepatitis B virus,HBV）感染是肝硬化的重要原因。研究显示，有效抑制HBV复制可改善肝纤维化^[1-2]，延缓或阻止代偿期肝硬化向失代偿期的进展，减少失代偿期患者病情进一步恶化，减少门静脉高压及相关并发症发生^[3-6]，延长生存期^[3-4]。因此，有效的抗病毒治疗对改善疾病临床结局具有重要意义^[7]，也是目前HBV相关肝硬化整体治疗策略中的一个重要组成部分。
