AIM: To investigate the differentiated whole genome expression profiling of gastric high- and low-grade intraepithelial neoplasia and early-stage adenocarcinoma.
目的:探讨乳腺癌组织FK506结合蛋白38(FK506-binding protein 38,FKBP38)的表达水平及其与病理分级和临床分期的关系。方法:采用免疫组化检测100例正常乳腺组织、300例浸润性导管癌(Invasion ductal carcinoma,IDC)和59例浸润性小叶癌组...目的:探讨乳腺癌组织FK506结合蛋白38(FK506-binding protein 38,FKBP38)的表达水平及其与病理分级和临床分期的关系。方法:采用免疫组化检测100例正常乳腺组织、300例浸润性导管癌(Invasion ductal carcinoma,IDC)和59例浸润性小叶癌组织(Invasion lobular carcinoma,ILD)中FKBP38的表达水平,分析FKBP38蛋白表达水平与乳腺癌临床病理参数之间的关系。结果:免疫组化结果表明,与正常乳腺组织相比,FKBP38在浸润性导管癌及浸润性小叶癌组织中的表达水平均显著降低,具有统计学差异(P<0.0001)。通过进一步分析可知,在浸润性导管癌中,FKBP38蛋白表达水平随病理分级及临床分期的增加而降低,具有统计学差异,而FKBP38蛋白与孕激素受体(Progesterone receptor,PR)蛋白的表达呈负相关。此外,三阴性乳腺癌(Triple-negative breast cancer,TNBC)FKBP38的表达水平显著高于非三阴性乳腺癌,同样,FKBP38在TNBC的表达水平随原发性肿瘤分期的增加而降低。结论:FKBP38蛋白水平在乳腺癌患者中表达水平显著降低,并与乳腺癌的病理分级、临床分期相关。这提示FKBP38蛋白水平可作为乳腺癌诊断和治疗的潜在靶点,但其作用机制仍需进一步研究。展开更多
AIM: To examine the correlation of phosphatidylinositol 3-kinase (PIK3) CB expression with preoperative radiotherapy response in patients with stage II/III rectal adenocarcinoma.
基金Supported by The specific grants of Public-Funded Projects in the Health Industry,Grant 200902002
文摘AIM: To investigate the differentiated whole genome expression profiling of gastric high- and low-grade intraepithelial neoplasia and early-stage adenocarcinoma.
文摘目的:探讨乳腺癌组织FK506结合蛋白38(FK506-binding protein 38,FKBP38)的表达水平及其与病理分级和临床分期的关系。方法:采用免疫组化检测100例正常乳腺组织、300例浸润性导管癌(Invasion ductal carcinoma,IDC)和59例浸润性小叶癌组织(Invasion lobular carcinoma,ILD)中FKBP38的表达水平,分析FKBP38蛋白表达水平与乳腺癌临床病理参数之间的关系。结果:免疫组化结果表明,与正常乳腺组织相比,FKBP38在浸润性导管癌及浸润性小叶癌组织中的表达水平均显著降低,具有统计学差异(P<0.0001)。通过进一步分析可知,在浸润性导管癌中,FKBP38蛋白表达水平随病理分级及临床分期的增加而降低,具有统计学差异,而FKBP38蛋白与孕激素受体(Progesterone receptor,PR)蛋白的表达呈负相关。此外,三阴性乳腺癌(Triple-negative breast cancer,TNBC)FKBP38的表达水平显著高于非三阴性乳腺癌,同样,FKBP38在TNBC的表达水平随原发性肿瘤分期的增加而降低。结论:FKBP38蛋白水平在乳腺癌患者中表达水平显著降低,并与乳腺癌的病理分级、临床分期相关。这提示FKBP38蛋白水平可作为乳腺癌诊断和治疗的潜在靶点,但其作用机制仍需进一步研究。
基金Supported by Grants from the National Natural Science Foundation of China No.30872923the Peking University People’s Hospital Research and Development Fund No.RDB2007-47,No.RDK2008-01 and No.RDB2011-25
文摘AIM: To examine the correlation of phosphatidylinositol 3-kinase (PIK3) CB expression with preoperative radiotherapy response in patients with stage II/III rectal adenocarcinoma.
