AIM: To investigate the therapeutic effect of traditional Chinese traditional medicines Da Cheng Qi Decoction (Timely-Purging and Yin-Preserving Decoction) and Glauber's salt combined with conservative measures on...AIM: To investigate the therapeutic effect of traditional Chinese traditional medicines Da Cheng Qi Decoction (Timely-Purging and Yin-Preserving Decoction) and Glauber's salt combined with conservative measures on abdominal compartment syndrome (ACS) in severe acute pancreatitis (SAP) patients. METHODS: Eighty consecutive SAP patients, admitted for routine non-operative conservative treatment, were randomly divided into study group and control group (40 patients in each group). Patients in the study group received Da Cheng Qi Decoction enema for 2 h and external use of Glauber's salt, once a day for 7 d. Patients in the control group received normal saline (NS) enema. Routine non-operative conservative treatments included non-per os nutrition (NPON), gastrointestinal decompression, life support, total parenteral nutrition (TPN), continuous peripancreatic vascular pharmaceutical infusion and drug therapy. Intra-cystic pressure (ICP) of the two groups was measured during treatment. The effectiveness and outcomes of treatment were observed and APACHE Ⅱ scores were applied in analysis. RESULTS: On days 4 and 5 of treatment, the ICP was lower in the study group than in the control group(P < 0.05). On days 3-5 of treatment, acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) scores for the study and control groups were significantly different (P < 0.05). Both the effectiveness and outcome of the treatment with Da Cheng Qi Decoction on abdominalgia, burbulence relief time, ascites quantity, cyst formation rate and hospitalization time were quite different between the two groups (P < 0.05). The mortality rate for the two groups had no significant difference. CONCLUSION: Da Cheng Qi Decoction enema and external use of Glauber's salt combined with routine non-operative conservative treatment can decrease the intra-abdominal pressure (IAP) of SAP patients and have preventive and therapeutic effects on abdominal compartment syndrome of SAP.展开更多
[目的]探讨大黄灌肠配合芒硝外敷对急性胰腺炎(Acute Pancreatitis,AP)辅助治疗的临床疗效。[方法]选取诸暨市中医院从2010年4月至2014年4月收治的60例AP患者,随机分成治疗组和对照组,每组各30例,治疗组在西医常规治疗的基础上加用大黄...[目的]探讨大黄灌肠配合芒硝外敷对急性胰腺炎(Acute Pancreatitis,AP)辅助治疗的临床疗效。[方法]选取诸暨市中医院从2010年4月至2014年4月收治的60例AP患者,随机分成治疗组和对照组,每组各30例,治疗组在西医常规治疗的基础上加用大黄灌肠配合芒硝外敷治疗,对照组则仅予西医常规治疗。治疗7d后观察两组的治疗效果。采用急性生理功能和慢性健康状况评分系统Ⅱ(acute Physiology and chronic health evaluationⅡ,APACHEⅡ)及标准床旁急性胰腺炎严重度评分(bedside index for severity in AP,BISAP)对患者进行评估,记录患者排气排便、肠鸣音恢复情况,监测血清淀粉酶及CRP指标变化,比较两组治疗前后APACHEII、BISAP评分。[结果]治疗组临床有效率为90%,明显优于对照组的73.33%,差异有统计学意义(P<0.05);治疗组患者排气排便次数、肠鸣音均得以明显改善,血清淀粉酶、C反应蛋白指标明显下降,差异有统计学意义(P<0.05),APACHEII、BISAP评分明显下降,差异有统计学意义(P<0.05);两组治疗前后排气排便次数、肠鸣音、血清淀粉酶、C反应蛋白指标、APACHEII、BISAP差值比较,差异均有统计学意义(P<0.05)。[结论]大黄灌肠配合芒硝外敷辅助治疗,可有效缓解AP患者腹痛、排气排便等临床症状,降低炎症反应。展开更多
文摘AIM: To investigate the therapeutic effect of traditional Chinese traditional medicines Da Cheng Qi Decoction (Timely-Purging and Yin-Preserving Decoction) and Glauber's salt combined with conservative measures on abdominal compartment syndrome (ACS) in severe acute pancreatitis (SAP) patients. METHODS: Eighty consecutive SAP patients, admitted for routine non-operative conservative treatment, were randomly divided into study group and control group (40 patients in each group). Patients in the study group received Da Cheng Qi Decoction enema for 2 h and external use of Glauber's salt, once a day for 7 d. Patients in the control group received normal saline (NS) enema. Routine non-operative conservative treatments included non-per os nutrition (NPON), gastrointestinal decompression, life support, total parenteral nutrition (TPN), continuous peripancreatic vascular pharmaceutical infusion and drug therapy. Intra-cystic pressure (ICP) of the two groups was measured during treatment. The effectiveness and outcomes of treatment were observed and APACHE Ⅱ scores were applied in analysis. RESULTS: On days 4 and 5 of treatment, the ICP was lower in the study group than in the control group(P < 0.05). On days 3-5 of treatment, acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) scores for the study and control groups were significantly different (P < 0.05). Both the effectiveness and outcome of the treatment with Da Cheng Qi Decoction on abdominalgia, burbulence relief time, ascites quantity, cyst formation rate and hospitalization time were quite different between the two groups (P < 0.05). The mortality rate for the two groups had no significant difference. CONCLUSION: Da Cheng Qi Decoction enema and external use of Glauber's salt combined with routine non-operative conservative treatment can decrease the intra-abdominal pressure (IAP) of SAP patients and have preventive and therapeutic effects on abdominal compartment syndrome of SAP.
文摘[目的]探讨大黄灌肠配合芒硝外敷对急性胰腺炎(Acute Pancreatitis,AP)辅助治疗的临床疗效。[方法]选取诸暨市中医院从2010年4月至2014年4月收治的60例AP患者,随机分成治疗组和对照组,每组各30例,治疗组在西医常规治疗的基础上加用大黄灌肠配合芒硝外敷治疗,对照组则仅予西医常规治疗。治疗7d后观察两组的治疗效果。采用急性生理功能和慢性健康状况评分系统Ⅱ(acute Physiology and chronic health evaluationⅡ,APACHEⅡ)及标准床旁急性胰腺炎严重度评分(bedside index for severity in AP,BISAP)对患者进行评估,记录患者排气排便、肠鸣音恢复情况,监测血清淀粉酶及CRP指标变化,比较两组治疗前后APACHEII、BISAP评分。[结果]治疗组临床有效率为90%,明显优于对照组的73.33%,差异有统计学意义(P<0.05);治疗组患者排气排便次数、肠鸣音均得以明显改善,血清淀粉酶、C反应蛋白指标明显下降,差异有统计学意义(P<0.05),APACHEII、BISAP评分明显下降,差异有统计学意义(P<0.05);两组治疗前后排气排便次数、肠鸣音、血清淀粉酶、C反应蛋白指标、APACHEII、BISAP差值比较,差异均有统计学意义(P<0.05)。[结论]大黄灌肠配合芒硝外敷辅助治疗,可有效缓解AP患者腹痛、排气排便等临床症状,降低炎症反应。
