目的探讨中药六味地黄软胶囊和银杏叶片对2型糖尿病患者血清受活化调节、由正常T细胞表达和分泌的趋化蛋白(regulated upon activation,normal T-cell expressed and secreted,RANTES)水平的影响。方法在西药降糖治疗基础上,40例早期2...目的探讨中药六味地黄软胶囊和银杏叶片对2型糖尿病患者血清受活化调节、由正常T细胞表达和分泌的趋化蛋白(regulated upon activation,normal T-cell expressed and secreted,RANTES)水平的影响。方法在西药降糖治疗基础上,40例早期2型糖尿病患者,随机分为中药组和安慰剂组,每组20例,分别给予六味地黄软胶囊及银杏叶片或安慰剂治疗6个月,检测治疗前后血清RANTES、血糖、血脂、糖化血红蛋白及尿微量白蛋白水平。结果中药组治疗后血清RANTES较治疗前明显下降,且明显低于安慰剂组(P<0.05)。结论六味地黄软胶囊及银杏叶片可降低2型糖尿病患者血清RANTES水平,可能通过抗炎机制防治糖尿病并发症。展开更多
Objective To study the anti-liver fibrosis effect of Ginkgo leaf in patients with chronic hepatitis B.Methods: Eighty-six patients with chronic hepatitis B were randomly divided into two groups with similar general c...Objective To study the anti-liver fibrosis effect of Ginkgo leaf in patients with chronic hepatitis B.Methods: Eighty-six patients with chronic hepatitis B were randomly divided into two groups with similar general condition. The 42 patients in the treated group were treated with Ginkgo leaf tablet (GLT), and the 44 patients in the control group were treated with Yiganling tablet. The treatment was conducted for 3 successive months in both groups. Changes in the histo-pathology of liver, serum levels of platelet activating factor (PAF), hyaluronic acid (HA), collagen type IV (C-IV), laminin (LN) and pro-collagen peptide type III (PC III) were observed before and after treatment. Results The markedly effective rate and the total effective rate in the treated group were 45.1% and 76.2% respectively, while in the control group the corresponding rates were 18. 2% and 43. 2%. Comparison between the two groups showed significant differenceP<0.01). Serum levels of PAF, HA, C-IV, LN and PC III were lowered significantly in the treated group after treatment. Compared with the corresponding parameters in the control group after treatment, the differences were all significant (P<0.01 orP<0.05). The pathological examination of liver showed improvement in both groups, the inflammation grade lowered in 10 patients (55. 6%) of the treated group and in 5 patients (35. 7%) of the control group, insignificant difference was shown between them. But in comparing the fibrosis staging lowering patients between the two groups, 12 patients (66. 7%) vs 3 patients (21.4%), the difference was significantP<0.05). Moreover, there were 4 patients in the control group with their fibrosis aggravated, while in the treated group, none was aggravatedP<0.05). Conclusion Ginkgo leaf tablet has some liver protective and anti-liver fibrosis benefits.展开更多
文摘目的探讨中药六味地黄软胶囊和银杏叶片对2型糖尿病患者血清受活化调节、由正常T细胞表达和分泌的趋化蛋白(regulated upon activation,normal T-cell expressed and secreted,RANTES)水平的影响。方法在西药降糖治疗基础上,40例早期2型糖尿病患者,随机分为中药组和安慰剂组,每组20例,分别给予六味地黄软胶囊及银杏叶片或安慰剂治疗6个月,检测治疗前后血清RANTES、血糖、血脂、糖化血红蛋白及尿微量白蛋白水平。结果中药组治疗后血清RANTES较治疗前明显下降,且明显低于安慰剂组(P<0.05)。结论六味地黄软胶囊及银杏叶片可降低2型糖尿病患者血清RANTES水平,可能通过抗炎机制防治糖尿病并发症。
文摘Objective To study the anti-liver fibrosis effect of Ginkgo leaf in patients with chronic hepatitis B.Methods: Eighty-six patients with chronic hepatitis B were randomly divided into two groups with similar general condition. The 42 patients in the treated group were treated with Ginkgo leaf tablet (GLT), and the 44 patients in the control group were treated with Yiganling tablet. The treatment was conducted for 3 successive months in both groups. Changes in the histo-pathology of liver, serum levels of platelet activating factor (PAF), hyaluronic acid (HA), collagen type IV (C-IV), laminin (LN) and pro-collagen peptide type III (PC III) were observed before and after treatment. Results The markedly effective rate and the total effective rate in the treated group were 45.1% and 76.2% respectively, while in the control group the corresponding rates were 18. 2% and 43. 2%. Comparison between the two groups showed significant differenceP<0.01). Serum levels of PAF, HA, C-IV, LN and PC III were lowered significantly in the treated group after treatment. Compared with the corresponding parameters in the control group after treatment, the differences were all significant (P<0.01 orP<0.05). The pathological examination of liver showed improvement in both groups, the inflammation grade lowered in 10 patients (55. 6%) of the treated group and in 5 patients (35. 7%) of the control group, insignificant difference was shown between them. But in comparing the fibrosis staging lowering patients between the two groups, 12 patients (66. 7%) vs 3 patients (21.4%), the difference was significantP<0.05). Moreover, there were 4 patients in the control group with their fibrosis aggravated, while in the treated group, none was aggravatedP<0.05). Conclusion Ginkgo leaf tablet has some liver protective and anti-liver fibrosis benefits.
