Background Sporadic fundic gland polyps （FGPs） are common gastric polyps.Some studies reported that FGPs dramatically increased due to proton pump inhibitors （PPIs） use and a decreased prevalence of Helicobacter p...Background Sporadic fundic gland polyps （FGPs） are common gastric polyps.Some studies reported that FGPs dramatically increased due to proton pump inhibitors （PPIs） use and a decreased prevalence of Helicobacter pylori （H.pylon） infection in Western countries.However,data are still controversial.This study aimed to identify the relationships between these two factors and FGPs in China.Methods Consecutive patients with FGPs detected were retrospectively analyzed.Data including patients＇ age,sex,symptoms,H.pylori infection,history of PPIs use,and the polyps were documented.Each patient was compared with two randomly selected age-and sex-matched controls with similar symptoms in the same period.Results During the period from March 2011 to March 2012,a total of 328 patients were diagnosed as FGPs in 23 047 patients who underwent routine esophagogastroduodenoscopy and 656 patients without FGPs as controls.The mean age was （55.12±12.61） years,and 75.91％ were women.The prevalence of H.pylori in patients with FGPs was significantly lower than in those without FGPs （22.30％ （64/287） vs.42.26％ （224/530）,P ＜0.001,OR 0.392,95％ Cl 0.283-0.544）.Overall,a total of 54 patients with FGPs （54/328,16.46％） and 136 patients without FGPs （136/656,20.73％） received PPIs therapy （P=0.110）.According to the different duration of PPIs use,no significant differences of PPIs use were found between the cases and controls among all subgroups.Moreover,the PPIs use was also similar,regardless of age,sex,H.pylori infection,and the number of polyps.Conclusion Sporadic FGPs may not be induced by PPIs therapy but negatively correlate with H.pylori infection in China,which is not the same with the data in Western countries.展开更多
目的:探讨胃底腺息肉(fundic gland polyps F G P s)的临床特征,及其与幽门螺旋杆菌(Helicobacter pylori,H.pylori)的关系.方法:收集深圳市人民医院消化内科2011-10/2013-10 276例FGPs患者的临床资料进行汇总分析,并按照FGPs患者的年...目的:探讨胃底腺息肉(fundic gland polyps F G P s)的临床特征,及其与幽门螺旋杆菌(Helicobacter pylori,H.pylori)的关系.方法:收集深圳市人民医院消化内科2011-10/2013-10 276例FGPs患者的临床资料进行汇总分析,并按照FGPs患者的年龄、性别比例选取胃镜检查正常的患者276例为对照组,分析FGPs与H.pylori感染的关系.结果:在行胃镜检查31680例患者中,检出276例胃底腺息肉,检出率为0.87%,以女性多见.临床上多为常规体检发现,部分表现为功能性消化不良和胃食管反流病.胃镜下多表现为胃体136例(49.3%),其次为胃底息肉108例(39.1%),单发197例(71.4%)或多发79例(28.6%).病理表现为息肉内有被覆胃底腺的上皮的囊肿,均无异形增生或肠上皮化生.FGPs病例组与对照组相比,病例组中H.pylori的感染率明显减低(OR=0.135,95%CI:0.073-0.250).结论:胃底腺息肉是一种具有良性倾向的息肉,其与H.pylori感染呈负相关.展开更多
Sporadic fundic gland polyps （FGPs） account for 0.8%- 1.9% of all gastric polyps and are observed in patients undergoing esophagogastroduodenoscopy （EGD） in whom they account for more than 50% of all gastric polyp...Sporadic fundic gland polyps （FGPs） account for 0.8%- 1.9% of all gastric polyps and are observed in patients undergoing esophagogastroduodenoscopy （EGD） in whom they account for more than 50% of all gastric polyps. The prevalence is increasing in recent years possibly due to decreased Helicobacter pylori （1t. pylori） infection rate and long-term proton pump inhibitor use. Generally, sporadic FGPs are assumed to be benign polyps with no risk of malignant transformation. We evaluated the feasibility of predicting sporadic FGPs based on typical endoscopic appearance in a large database of 47 771 endoscopies.展开更多
目的探讨胃底腺息肉(fundic gland polyps,FGPs)与结直肠肿瘤的相关性.方法回顾性收集2013-05/2016-05所有在吉林大学第一医院同期行胃镜及肠镜检查的患者病历资料,分为FGPs组(243例)和对照组(486例).使用SPSS17.0软件进行统计分析,探讨...目的探讨胃底腺息肉(fundic gland polyps,FGPs)与结直肠肿瘤的相关性.方法回顾性收集2013-05/2016-05所有在吉林大学第一医院同期行胃镜及肠镜检查的患者病历资料,分为FGPs组(243例)和对照组(486例).使用SPSS17.0软件进行统计分析,探讨FGPs和结直肠肿瘤的相关性.结果F G P s组结直肠肿瘤检出率高于对照组[19.8%(48/243)vs 8.8%(43/486)],其中结直肠癌的检出率差异无统计学意义(P=0.67),而结直肠腺瘤的检出率差异有统计学意义(P<0.001).通过对年龄、性别进行分层分析得出,女性及≥50岁的FGPs患者的结直肠肿瘤检出率明显高于对照组(P<0.001,0.001).进一步就不同部位的结直肠肿瘤分层分析显示,FGPs合并结直肠肿瘤的患者中,女性及≥50岁的,无论是在近端结肠还是远端结直肠,结直肠肿瘤检出率均高于对照组(P<0.05).结论患有FGPs尤其是女性及≥50岁的患者,合并近端结肠及远端结直肠肿瘤的风险增高,应尽早行肠镜检查.展开更多
AIM:To assess the risk of colonic polyps,adenomas and advanced neoplastic lesions(ANL) in patients with sporadic gastric polyps,especially those with fundic gland polyps(FGP).METHODS:Clinical records of patients who ... AIM:To assess the risk of colonic polyps,adenomas and advanced neoplastic lesions(ANL) in patients with sporadic gastric polyps,especially those with fundic gland polyps(FGP).METHODS:Clinical records of patients who had performed an upper and a lower digestive endoscopy between September 2007 and August 2008 were retrospectively analyzed.A case-control study was carried out,calling patients with gastric polyps as 'cases' and patients without gastric polyps as 'controls'.The risk of colonic polyps,adenomas and ANL(villous component ≥ 25%,size ≥ 10 mm,or high grade dysplasia) was assessed [odds ratio(OR) and its corresponding 95%CI].RESULTS:Two hundred and forty seven patients were analyzed:78 with gastric polyps(cases) and 169 without gastric polyps(controls).Among the cases,the majority of gastric polyps were FGP(80%,CI:69-88) and hyperplastic(20%,CI:12-31);25% had colonic polyps(25% hyperplastic and 68% adenomas,from which 45% were ANL).Among the controls,20% had colonic polyps(31% hyperplastic and 63% adenomas,from which 41% were ANL).The patients with sporadic FGP had an OR of 1.56(CI:0.80-3.04) for colonic polyps,an OR of 1.78(CI:0.82-3.84) for colonic adenomas,and an OR of 0.80(CI:0.21-2.98) for ANL.Similar results were found in patients with gastric polyps in general.CONCLUSION:The results of this study did not show more risk of colorectal adenomas or ANL neither in patients with sporadic gastric polyps nor in those with FGP.展开更多
基金This study was supported by grants from the National Natural Science Foundation of China （No.81300272 and No.81070283）,Research Fund for the Doctoral Program of Higher Education of China （No.20121202110018）,and Tianjin Research Program of Application Foundation and Advanced Technology of China （No.13JCQNJC10600）.
文摘Background Sporadic fundic gland polyps （FGPs） are common gastric polyps.Some studies reported that FGPs dramatically increased due to proton pump inhibitors （PPIs） use and a decreased prevalence of Helicobacter pylori （H.pylon） infection in Western countries.However,data are still controversial.This study aimed to identify the relationships between these two factors and FGPs in China.Methods Consecutive patients with FGPs detected were retrospectively analyzed.Data including patients＇ age,sex,symptoms,H.pylori infection,history of PPIs use,and the polyps were documented.Each patient was compared with two randomly selected age-and sex-matched controls with similar symptoms in the same period.Results During the period from March 2011 to March 2012,a total of 328 patients were diagnosed as FGPs in 23 047 patients who underwent routine esophagogastroduodenoscopy and 656 patients without FGPs as controls.The mean age was （55.12±12.61） years,and 75.91％ were women.The prevalence of H.pylori in patients with FGPs was significantly lower than in those without FGPs （22.30％ （64/287） vs.42.26％ （224/530）,P ＜0.001,OR 0.392,95％ Cl 0.283-0.544）.Overall,a total of 54 patients with FGPs （54/328,16.46％） and 136 patients without FGPs （136/656,20.73％） received PPIs therapy （P=0.110）.According to the different duration of PPIs use,no significant differences of PPIs use were found between the cases and controls among all subgroups.Moreover,the PPIs use was also similar,regardless of age,sex,H.pylori infection,and the number of polyps.Conclusion Sporadic FGPs may not be induced by PPIs therapy but negatively correlate with H.pylori infection in China,which is not the same with the data in Western countries.
文摘目的:探讨胃底腺息肉(fundic gland polyps F G P s)的临床特征,及其与幽门螺旋杆菌(Helicobacter pylori,H.pylori)的关系.方法:收集深圳市人民医院消化内科2011-10/2013-10 276例FGPs患者的临床资料进行汇总分析,并按照FGPs患者的年龄、性别比例选取胃镜检查正常的患者276例为对照组,分析FGPs与H.pylori感染的关系.结果:在行胃镜检查31680例患者中,检出276例胃底腺息肉,检出率为0.87%,以女性多见.临床上多为常规体检发现,部分表现为功能性消化不良和胃食管反流病.胃镜下多表现为胃体136例(49.3%),其次为胃底息肉108例(39.1%),单发197例(71.4%)或多发79例(28.6%).病理表现为息肉内有被覆胃底腺的上皮的囊肿,均无异形增生或肠上皮化生.FGPs病例组与对照组相比,病例组中H.pylori的感染率明显减低(OR=0.135,95%CI:0.073-0.250).结论:胃底腺息肉是一种具有良性倾向的息肉,其与H.pylori感染呈负相关.
基金This study was supported by grants from the National Natural Science Foundation of China，Tianjin Research Program of Application Foundation and Advanced Technology for Young Scientists
文摘Sporadic fundic gland polyps （FGPs） account for 0.8%- 1.9% of all gastric polyps and are observed in patients undergoing esophagogastroduodenoscopy （EGD） in whom they account for more than 50% of all gastric polyps. The prevalence is increasing in recent years possibly due to decreased Helicobacter pylori （1t. pylori） infection rate and long-term proton pump inhibitor use. Generally, sporadic FGPs are assumed to be benign polyps with no risk of malignant transformation. We evaluated the feasibility of predicting sporadic FGPs based on typical endoscopic appearance in a large database of 47 771 endoscopies.
文摘目的探讨胃底腺息肉(fundic gland polyps,FGPs)与结直肠肿瘤的相关性.方法回顾性收集2013-05/2016-05所有在吉林大学第一医院同期行胃镜及肠镜检查的患者病历资料,分为FGPs组(243例)和对照组(486例).使用SPSS17.0软件进行统计分析,探讨FGPs和结直肠肿瘤的相关性.结果F G P s组结直肠肿瘤检出率高于对照组[19.8%(48/243)vs 8.8%(43/486)],其中结直肠癌的检出率差异无统计学意义(P=0.67),而结直肠腺瘤的检出率差异有统计学意义(P<0.001).通过对年龄、性别进行分层分析得出,女性及≥50岁的FGPs患者的结直肠肿瘤检出率明显高于对照组(P<0.001,0.001).进一步就不同部位的结直肠肿瘤分层分析显示,FGPs合并结直肠肿瘤的患者中,女性及≥50岁的,无论是在近端结肠还是远端结直肠,结直肠肿瘤检出率均高于对照组(P<0.05).结论患有FGPs尤其是女性及≥50岁的患者,合并近端结肠及远端结直肠肿瘤的风险增高,应尽早行肠镜检查.
文摘 AIM:To assess the risk of colonic polyps,adenomas and advanced neoplastic lesions(ANL) in patients with sporadic gastric polyps,especially those with fundic gland polyps(FGP).METHODS:Clinical records of patients who had performed an upper and a lower digestive endoscopy between September 2007 and August 2008 were retrospectively analyzed.A case-control study was carried out,calling patients with gastric polyps as 'cases' and patients without gastric polyps as 'controls'.The risk of colonic polyps,adenomas and ANL(villous component ≥ 25%,size ≥ 10 mm,or high grade dysplasia) was assessed [odds ratio(OR) and its corresponding 95%CI].RESULTS:Two hundred and forty seven patients were analyzed:78 with gastric polyps(cases) and 169 without gastric polyps(controls).Among the cases,the majority of gastric polyps were FGP(80%,CI:69-88) and hyperplastic(20%,CI:12-31);25% had colonic polyps(25% hyperplastic and 68% adenomas,from which 45% were ANL).Among the controls,20% had colonic polyps(31% hyperplastic and 63% adenomas,from which 41% were ANL).The patients with sporadic FGP had an OR of 1.56(CI:0.80-3.04) for colonic polyps,an OR of 1.78(CI:0.82-3.84) for colonic adenomas,and an OR of 0.80(CI:0.21-2.98) for ANL.Similar results were found in patients with gastric polyps in general.CONCLUSION:The results of this study did not show more risk of colorectal adenomas or ANL neither in patients with sporadic gastric polyps nor in those with FGP.
