The simplification of fatigue load spectrum,which can effectively reduce experimental cost,is of great importance for structural fatigue tests.By introducing random variables,the probabilistic tolerance method of remo...The simplification of fatigue load spectrum,which can effectively reduce experimental cost,is of great importance for structural fatigue tests.By introducing random variables,the probabilistic tolerance method of removing small amplitude cycles proposed in this paper takes into account the randomness of both load and fatigue limit.The probability of the damage occurrence caused by the removed small loads is calculated to ensure that it cannot exceed the given probabilistic tolerance.Accordingly,the omission level is obtained and the truncated spectrum is formed.The unnotched aluminum sheet specimens are used to perform the fatigue test on the original fatigue spectrum and truncated fatigue spectrum of a transporter.The test results show that there is no statistical difference between the test life of the truncated spectrum and that of the original spectrum,which demonstrates the validity of the small-load-omitting method that considers randomness.展开更多
The astrocyte is a critical regulator of neuronal survival after ischemic brain injury. Electroacupuncture may be an effective therapy for cerebral ischemia, as electroacupuncture frequency can affect the structural i...The astrocyte is a critical regulator of neuronal survival after ischemic brain injury. Electroacupuncture may be an effective therapy for cerebral ischemia, as electroacupuncture frequency can affect the structural integdty of astrocytes. In this study, a rat model of middle cerebral artery occlusion established using the modified thread embolism method was treated with electroacupuncture of the bilateral Quchi （Llll） and Zusanfi （ST36） at 15, 30, and 100 Hz frequencies. Behavioral testing, immunohistochemistry and electron microscopy were used to explore the effect of these electroacupuncture frequencies used on maintaining the structural integrity of ischemic brain tissue. Compared with the model and 100 Hz electroacupuncture groups the 15 and 30 Hz electroacupuncture groups displayed decreased neurological deficit scores, as evaluated by the ＂Longa＂ method, significantly increased glial fibrillary acidic protein expression, and alleviated ultrastructural damage of astrocytes at the edge of the infarct. Our experimental findings indicate that 15 and 30 Hz electroacupuncture intervention can favorably maintain the structural integrity of astrocytes and play a protective role in cerebral ischemic injury. Astrocyte structural integrity may be the mechanism underlying acupuncture production of ischemic tolerance展开更多
基金supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)National Natural Science Foundations of China(Nos.52075244,52002181)。
文摘The simplification of fatigue load spectrum,which can effectively reduce experimental cost,is of great importance for structural fatigue tests.By introducing random variables,the probabilistic tolerance method of removing small amplitude cycles proposed in this paper takes into account the randomness of both load and fatigue limit.The probability of the damage occurrence caused by the removed small loads is calculated to ensure that it cannot exceed the given probabilistic tolerance.Accordingly,the omission level is obtained and the truncated spectrum is formed.The unnotched aluminum sheet specimens are used to perform the fatigue test on the original fatigue spectrum and truncated fatigue spectrum of a transporter.The test results show that there is no statistical difference between the test life of the truncated spectrum and that of the original spectrum,which demonstrates the validity of the small-load-omitting method that considers randomness.
基金supported by a grant from the Guangxi Administration of Traditional Chinese Medicine,No.GZZC0962
文摘The astrocyte is a critical regulator of neuronal survival after ischemic brain injury. Electroacupuncture may be an effective therapy for cerebral ischemia, as electroacupuncture frequency can affect the structural integdty of astrocytes. In this study, a rat model of middle cerebral artery occlusion established using the modified thread embolism method was treated with electroacupuncture of the bilateral Quchi （Llll） and Zusanfi （ST36） at 15, 30, and 100 Hz frequencies. Behavioral testing, immunohistochemistry and electron microscopy were used to explore the effect of these electroacupuncture frequencies used on maintaining the structural integrity of ischemic brain tissue. Compared with the model and 100 Hz electroacupuncture groups the 15 and 30 Hz electroacupuncture groups displayed decreased neurological deficit scores, as evaluated by the ＂Longa＂ method, significantly increased glial fibrillary acidic protein expression, and alleviated ultrastructural damage of astrocytes at the edge of the infarct. Our experimental findings indicate that 15 and 30 Hz electroacupuncture intervention can favorably maintain the structural integrity of astrocytes and play a protective role in cerebral ischemic injury. Astrocyte structural integrity may be the mechanism underlying acupuncture production of ischemic tolerance
