Background The airway inflammation could be assessed by some noninvasive approaches. To investigate the value of eosinophil counts in induced sputum and fractional concentration of exhaled nitric oxide （FENO） for th...Background The airway inflammation could be assessed by some noninvasive approaches. To investigate the value of eosinophil counts in induced sputum and fractional concentration of exhaled nitric oxide （FENO） for the regimen adjustment in patients with asthma, the correlation was analyzed between the two parameters and lung function parameter （forced expiratory volume in one second （FEV1））. Methods Sixty-five outpatients with mild to moderate non-exacerbation asthma from Beijing Chao-Yang Hospital were enrolled as treatment group. Combined medications of inhaled corticosteroids plus long-acting beta-2 agonist were administered for one year. Lung function parameters, eosinophil counts in induced sputum, concentration of exhaled nitric oxide and the Asthma Control Test scores were recorded, at regular intervals in the follow-up period. Twenty-one healthy volunteers were enrolled as control group and underwent examination of eosinophil counts in induced sputum, lung function and concentration of exhaled nitric oxide. Results Sixty-three subjects from treatment group completed follow-up period for one year or longer. Mean FEV1 value of the 63 subjects was （2.75±0.54） L at baseline, （2.97±0.56） L and （3.07±0.52） L at month 3 and month 6, respectively, and maintained as （3.14±0.51） L in the following six months. Mean FENO decreased from （61±25） parts per billion （ppb） at baseline to （32±19） ppb at month 3 （P 〈0.05）, and continued to decrease to （22±12） ppb at month 6, the difference being significant when compared to both baseline and control group （（13±8） ppb）. Mean eosinophil counts decreased to （0.032±0.011） ×106/ml at month 3, which was significantly different from baseline （（0.093±_0.023） xl06/ml） and the control group （（0.005±0.003）×l06/ml （both P 〈0.05）. The eosinophil counts in induced sputum correlated positively with concentration of FENO in the first six months （all P 〈0.05）. The concentration of FENO had a s展开更多
Background The respiratory system changes with age and a better understanding of the changes contribute to detect and prevent respiratory dysfunctions in old population. The purpose of this study was to observe age-as...Background The respiratory system changes with age and a better understanding of the changes contribute to detect and prevent respiratory dysfunctions in old population. The purpose of this study was to observe age-associated changes of pulmonary function parameters in healthy young adults and the elderly. Methods A cross-sectional study was conducted among 600 male and female subjects aged 19 to 92 years. The subjects were divided into three groups by age： young adult （19-39 years）, middle-aged adult （40-59 years）, and the elderly （〉60 years）. The pulmonary function was measured with routine examination methods and 13 parameters including vital capacity （VC）, residual volume （RV）, functional residual capacity （FRC）, total lung capacity （TLC）, RV/TLC, forced vital capacity （FVC）, forced expiratory volume in one second （FEV1）, FEV1/FVC, peak expiratory flow （PEF）, forced expiratory flow at 25% of FVC exhaled （FEF25）, forced expiratory flow at 50% of FVC exhaled （FEF50）, diffusion capacity of the lung for carbon monoxide （DLCO）, and specific diffusion capacity of CO （KCO） were collected and analyzed. Changes in pulmonary function parameters among the influence on FEVJFVC and RV were studied further. Results Ten pulmonary function parameters including VC, FVC, pre-elderly and elderly subjects, especially the aging FEV1, FEV1/FVC, PEF, FEF25, FEF50, TLC, DLCO and KCO decreased significantly with age in both male and female subjects （P 〈0.01）. RV and RV/TLC were increased with age （P 〈0.01）. FRC remained stable during aging. Except FRC, the linear relationship was significant between age and other pulmonary function parameters. In the pre-elderly and elderly subjects, RV had a non-significantly increasing tendency with age （P 〉0.05）, and FEV1/FVC did not change significantly with age （P 〉0.05）. Conclusion Total pulmonary function was declined tendency of RV and decreasing tendency of FEV1/FVC with advancing age, but FRC was stable, and展开更多
文摘Background The airway inflammation could be assessed by some noninvasive approaches. To investigate the value of eosinophil counts in induced sputum and fractional concentration of exhaled nitric oxide （FENO） for the regimen adjustment in patients with asthma, the correlation was analyzed between the two parameters and lung function parameter （forced expiratory volume in one second （FEV1））. Methods Sixty-five outpatients with mild to moderate non-exacerbation asthma from Beijing Chao-Yang Hospital were enrolled as treatment group. Combined medications of inhaled corticosteroids plus long-acting beta-2 agonist were administered for one year. Lung function parameters, eosinophil counts in induced sputum, concentration of exhaled nitric oxide and the Asthma Control Test scores were recorded, at regular intervals in the follow-up period. Twenty-one healthy volunteers were enrolled as control group and underwent examination of eosinophil counts in induced sputum, lung function and concentration of exhaled nitric oxide. Results Sixty-three subjects from treatment group completed follow-up period for one year or longer. Mean FEV1 value of the 63 subjects was （2.75±0.54） L at baseline, （2.97±0.56） L and （3.07±0.52） L at month 3 and month 6, respectively, and maintained as （3.14±0.51） L in the following six months. Mean FENO decreased from （61±25） parts per billion （ppb） at baseline to （32±19） ppb at month 3 （P 〈0.05）, and continued to decrease to （22±12） ppb at month 6, the difference being significant when compared to both baseline and control group （（13±8） ppb）. Mean eosinophil counts decreased to （0.032±0.011） ×106/ml at month 3, which was significantly different from baseline （（0.093±_0.023） xl06/ml） and the control group （（0.005±0.003）×l06/ml （both P 〈0.05）. The eosinophil counts in induced sputum correlated positively with concentration of FENO in the first six months （all P 〈0.05）. The concentration of FENO had a s
文摘Background The respiratory system changes with age and a better understanding of the changes contribute to detect and prevent respiratory dysfunctions in old population. The purpose of this study was to observe age-associated changes of pulmonary function parameters in healthy young adults and the elderly. Methods A cross-sectional study was conducted among 600 male and female subjects aged 19 to 92 years. The subjects were divided into three groups by age： young adult （19-39 years）, middle-aged adult （40-59 years）, and the elderly （〉60 years）. The pulmonary function was measured with routine examination methods and 13 parameters including vital capacity （VC）, residual volume （RV）, functional residual capacity （FRC）, total lung capacity （TLC）, RV/TLC, forced vital capacity （FVC）, forced expiratory volume in one second （FEV1）, FEV1/FVC, peak expiratory flow （PEF）, forced expiratory flow at 25% of FVC exhaled （FEF25）, forced expiratory flow at 50% of FVC exhaled （FEF50）, diffusion capacity of the lung for carbon monoxide （DLCO）, and specific diffusion capacity of CO （KCO） were collected and analyzed. Changes in pulmonary function parameters among the influence on FEVJFVC and RV were studied further. Results Ten pulmonary function parameters including VC, FVC, pre-elderly and elderly subjects, especially the aging FEV1, FEV1/FVC, PEF, FEF25, FEF50, TLC, DLCO and KCO decreased significantly with age in both male and female subjects （P 〈0.01）. RV and RV/TLC were increased with age （P 〈0.01）. FRC remained stable during aging. Except FRC, the linear relationship was significant between age and other pulmonary function parameters. In the pre-elderly and elderly subjects, RV had a non-significantly increasing tendency with age （P 〉0.05）, and FEV1/FVC did not change significantly with age （P 〉0.05）. Conclusion Total pulmonary function was declined tendency of RV and decreasing tendency of FEV1/FVC with advancing age, but FRC was stable, and
