目的评价五行音乐疗法对心血管疾病患者的疗效。方法通过计算机检索Pub Med、EMbase、the Cochrane Central Register of Controlled Trials(CENTRAL)、the ISI Web of Knowledge Databases、CBM、VIP、中国知网、中国优秀博硕士学位论...目的评价五行音乐疗法对心血管疾病患者的疗效。方法通过计算机检索Pub Med、EMbase、the Cochrane Central Register of Controlled Trials(CENTRAL)、the ISI Web of Knowledge Databases、CBM、VIP、中国知网、中国优秀博硕士学位论文全文数据库、万方数据库,在其中查找关于比较对心血管疾病运用五行音乐疗法与未运用五行音乐疗法的随机对照试验(RCT),检索时间为2000年1月31日—2015年10月31日。按纳入排除标准由2人独立筛选文献,进行资料提取并予以质量评价,采用Rev Man 5.3软件进行Meta分析。结果共纳入4项研究,322名受试者。Meta分析结果显示:比较干预组和对照组SAS评分、SDS评分、收缩压值和舒张压值,差异均具有统计学意义(Z=3.09,P=0.002;Z=10.81,P<0.000 01;Z=2.96,P=0.003;Z=5.24,P<0.000 01),其加权平均数及95%CI分别为-7.93(-12.95,-2.90),-10.28(-12.14,-8.41),-2.48(-4.12,-0.84),-3.09(-4.25,-1.94)。结论五行音乐疗法对心血管疾病患者焦虑及抑郁状况、收缩压及舒张压值有明显改善作用,仍需高质量、大样本、设计严谨的随机对照试验以进一步证实。展开更多
Objective:Jue tone is a kind of sound,using 3-mi as the main tone,and is melodious,profound,makes people feel comfortable and pleasant.This study aimed to explore the probable mechanism of Jue tone to reduce blood pre...Objective:Jue tone is a kind of sound,using 3-mi as the main tone,and is melodious,profound,makes people feel comfortable and pleasant.This study aimed to explore the probable mechanism of Jue tone to reduce blood pressure(BP)in hypertensive rats with a liver-fire hyperactivity pattern by observing changes in BP as well as physiochemical indexes in plasma.Methods:Sixteen male spontaneous hypertensive rats(SHR)with a liver-fire hyperactivity pattern were randomly divided into a control group and a Jue tone group.The rats in the Jue tone group were treated with Jue tone(55e65 dB,played by the five elements of music rhythm instrument,a kind of physiotherapy regimen music played by Shen Wu)once a day for 4 weeks.The BP levels in each group were measured twice a week,on Monday and Friday.The levels of angiotensin II(Ang-II),thromboxane B2(TXB2),endothelin-1(ET-1),calcitonin gene-related peptide(cGRP),norepinephrine(NE),cortisol(CORT),and 5-hydroxytryptamine(5-HT).in plasma were detected by enzyme-linked immunosorbent assay after 4 weeks of intervention.Results:BP and the levels of TXB2 and ET-1 in the plasma of the treatment group were significantly lower than those of the control group,while the level of cGRP was significantly higher.Conclusion:Jue tone can reduce the BP of hypertensive rats with a liver-fire hyperactivity pattern.The mechanism may correlate with a reduction in TXB2 and ET-1 and an increase in cGRP with the reduction of reactive oxygen species(ROS).展开更多
文摘目的评价五行音乐疗法对心血管疾病患者的疗效。方法通过计算机检索Pub Med、EMbase、the Cochrane Central Register of Controlled Trials(CENTRAL)、the ISI Web of Knowledge Databases、CBM、VIP、中国知网、中国优秀博硕士学位论文全文数据库、万方数据库,在其中查找关于比较对心血管疾病运用五行音乐疗法与未运用五行音乐疗法的随机对照试验(RCT),检索时间为2000年1月31日—2015年10月31日。按纳入排除标准由2人独立筛选文献,进行资料提取并予以质量评价,采用Rev Man 5.3软件进行Meta分析。结果共纳入4项研究,322名受试者。Meta分析结果显示:比较干预组和对照组SAS评分、SDS评分、收缩压值和舒张压值,差异均具有统计学意义(Z=3.09,P=0.002;Z=10.81,P<0.000 01;Z=2.96,P=0.003;Z=5.24,P<0.000 01),其加权平均数及95%CI分别为-7.93(-12.95,-2.90),-10.28(-12.14,-8.41),-2.48(-4.12,-0.84),-3.09(-4.25,-1.94)。结论五行音乐疗法对心血管疾病患者焦虑及抑郁状况、收缩压及舒张压值有明显改善作用,仍需高质量、大样本、设计严谨的随机对照试验以进一步证实。
基金The work was supported by Vertical Science Development Foundation of BUCM(2019-ZXFZJJ-039)National Innovation Training Program(201610026039)National Natural Science Foundation of China(81503382,81473521).
文摘Objective:Jue tone is a kind of sound,using 3-mi as the main tone,and is melodious,profound,makes people feel comfortable and pleasant.This study aimed to explore the probable mechanism of Jue tone to reduce blood pressure(BP)in hypertensive rats with a liver-fire hyperactivity pattern by observing changes in BP as well as physiochemical indexes in plasma.Methods:Sixteen male spontaneous hypertensive rats(SHR)with a liver-fire hyperactivity pattern were randomly divided into a control group and a Jue tone group.The rats in the Jue tone group were treated with Jue tone(55e65 dB,played by the five elements of music rhythm instrument,a kind of physiotherapy regimen music played by Shen Wu)once a day for 4 weeks.The BP levels in each group were measured twice a week,on Monday and Friday.The levels of angiotensin II(Ang-II),thromboxane B2(TXB2),endothelin-1(ET-1),calcitonin gene-related peptide(cGRP),norepinephrine(NE),cortisol(CORT),and 5-hydroxytryptamine(5-HT).in plasma were detected by enzyme-linked immunosorbent assay after 4 weeks of intervention.Results:BP and the levels of TXB2 and ET-1 in the plasma of the treatment group were significantly lower than those of the control group,while the level of cGRP was significantly higher.Conclusion:Jue tone can reduce the BP of hypertensive rats with a liver-fire hyperactivity pattern.The mechanism may correlate with a reduction in TXB2 and ET-1 and an increase in cGRP with the reduction of reactive oxygen species(ROS).
