Regulated cell death is a genetically determined form of programmed cell death that commonly occurs during the development of living organisms.This process plays a crucial role in modulating homeostasis and is evoluti...Regulated cell death is a genetically determined form of programmed cell death that commonly occurs during the development of living organisms.This process plays a crucial role in modulating homeostasis and is evolutionarily conserved across a diverse range of living organisms.Ferroptosis is a classic regulatory mode of cell death.Extensive studies of regulatory cell death in Alzheimer’s disease have yielded increasing evidence that fe rroptosis is closely related to the occurrence,development,and prognosis of Alzheimer’s disease.This review summarizes the molecular mechanisms of ferroptosis and recent research advances in the role of ferro ptosis in Alzheimer’s disease.Our findings are expected to serve as a theoretical and experimental foundation for clinical research and targeted therapy for Alzheimer’s disease.展开更多
The photo-Fenton reaction is a key source of the highly reactive hydroxyl radical(HOU) that is produced by the reaction of simultaneous photo-induced generation of Fe^(2+)-dissolved organic matter(DOM) with H_2...The photo-Fenton reaction is a key source of the highly reactive hydroxyl radical(HOU) that is produced by the reaction of simultaneous photo-induced generation of Fe^(2+)-dissolved organic matter(DOM) with H_2O_2 in sunlit surface waters as well as in the treatment of organic pollutants in the advanced oxidation processes(AOPs).Concentrations of both H_2O_2 and Fe^(2+)-DOM were dependent on time and total solar intensity flux,and their levels were highest in the diurnal samples collected at noon compared with the samples collected during the period before sunrise and after sunset.H_2O_2 and Fe^(2+)-DOM concentrations during monthly readings were also found higher in comparison with the diurnal samples,shortly before sunrise or after sunset.A π-electron bonding system is formed between Fe and the functional groups in DOM(Fe-DOM),through electron donation from the functional groups of DOM to an empty d-orbital of Fe.The π-electron is loosely bound and is highly susceptible to a rapid excitation upon light exposure that will provide better understanding of the formation of aqueous electrons,superoxide radical anions,H_2O_2 and finally,photo-Fenton reactions,too.Our results imply that simultaneous generation of H_2O_2 and Fe^(2+)-DOM upon sunlight exposure during the daytime is most likely to be the key photo-Fenton reaction pathway,taking place in surface waters.展开更多
基金supported by the National Natural Science Foundation of China,No.81501106(to CF)Fund of Taishan Scholar Project(to CF)+1 种基金the Natural Science Foundation of Shandong Province,No.ZR2020QH106(to YH)the Medical and Health Science and Technology Development Plan of Shandong Province,No.202203010799(to QS)。
文摘Regulated cell death is a genetically determined form of programmed cell death that commonly occurs during the development of living organisms.This process plays a crucial role in modulating homeostasis and is evolutionarily conserved across a diverse range of living organisms.Ferroptosis is a classic regulatory mode of cell death.Extensive studies of regulatory cell death in Alzheimer’s disease have yielded increasing evidence that fe rroptosis is closely related to the occurrence,development,and prognosis of Alzheimer’s disease.This review summarizes the molecular mechanisms of ferroptosis and recent research advances in the role of ferro ptosis in Alzheimer’s disease.Our findings are expected to serve as a theoretical and experimental foundation for clinical research and targeted therapy for Alzheimer’s disease.
基金the Japan Society for the Promotion of Science for the financial support through a Grant-in-Aid for Scientific Research (B) (No.18310010)partly supported by the Key Construction Program of the National "985" Project,Tianjin University,China
文摘The photo-Fenton reaction is a key source of the highly reactive hydroxyl radical(HOU) that is produced by the reaction of simultaneous photo-induced generation of Fe^(2+)-dissolved organic matter(DOM) with H_2O_2 in sunlit surface waters as well as in the treatment of organic pollutants in the advanced oxidation processes(AOPs).Concentrations of both H_2O_2 and Fe^(2+)-DOM were dependent on time and total solar intensity flux,and their levels were highest in the diurnal samples collected at noon compared with the samples collected during the period before sunrise and after sunset.H_2O_2 and Fe^(2+)-DOM concentrations during monthly readings were also found higher in comparison with the diurnal samples,shortly before sunrise or after sunset.A π-electron bonding system is formed between Fe and the functional groups in DOM(Fe-DOM),through electron donation from the functional groups of DOM to an empty d-orbital of Fe.The π-electron is loosely bound and is highly susceptible to a rapid excitation upon light exposure that will provide better understanding of the formation of aqueous electrons,superoxide radical anions,H_2O_2 and finally,photo-Fenton reactions,too.Our results imply that simultaneous generation of H_2O_2 and Fe^(2+)-DOM upon sunlight exposure during the daytime is most likely to be the key photo-Fenton reaction pathway,taking place in surface waters.