microRNAs (miRs) are small non-coding RNAs that regulate both mRNA and protein expression of target genes, which results in alterations in mRNA stability or translation inhibition. miRs influence at least one third of...microRNAs (miRs) are small non-coding RNAs that regulate both mRNA and protein expression of target genes, which results in alterations in mRNA stability or translation inhibition. miRs influence at least one third of all human transcripts and are known regulators of various important cellular growth and differentiation factors. miRs have recently emerged as key regulatory molecules in chronic liver disease. This review details recent contributions to the field of miRs that influence liver development and the broad spectrum of disease, from non-alcoholic fatty liver disease to fibrosis/cirrhosis, with particular emphasis on hepatic stellate cells and potential use of miRs as therapeutic tools.展开更多
根据英国结构完整性评估标准BS7910(2013),考虑焊接残余应力影响,采用失效评估图(Failure Assessment Diagram,FAD)方法对镍基合金压力容器焊接部位内表面裂纹进行安全评估。首先采用有限元分析(Finite Element Analysis,FEA)方法,对压...根据英国结构完整性评估标准BS7910(2013),考虑焊接残余应力影响,采用失效评估图(Failure Assessment Diagram,FAD)方法对镍基合金压力容器焊接部位内表面裂纹进行安全评估。首先采用有限元分析(Finite Element Analysis,FEA)方法,对压力容器V型、X型坡口环焊缝多层多道对接焊进行数值模拟,获取焊接残余应力分布,并将V型坡口对接焊焊接残余应力曲线与BS7910(2013)标准残余应力分布进行了对比;其次,对BS7910(2013)1级-FAC曲线进行公式化简,在焊接位置考虑残余应力、应力集中、塑性失效因子三因素的影响,对轴向内部半椭圆裂纹进行了失效应力预测。结果表明:残余应力的分布直接影响计算结果,残余拉应力越大,相应失效应力越小;残余应力值和裂纹深度a保持不变,失效应力计算结果随c/a(c为裂纹半长)增大而减小;当c/a比值不变,失效应力值随着a增大而减小。本文焊接残余应力模拟即及失效应力预测方法为以后含缺陷压力容器及管道失效应力计算(寿命预测)提供一定的参考。展开更多
基金Supported by Grants from NIH (DK38825, HLB AA014891,LWS)institutional funds from CMC
文摘microRNAs (miRs) are small non-coding RNAs that regulate both mRNA and protein expression of target genes, which results in alterations in mRNA stability or translation inhibition. miRs influence at least one third of all human transcripts and are known regulators of various important cellular growth and differentiation factors. miRs have recently emerged as key regulatory molecules in chronic liver disease. This review details recent contributions to the field of miRs that influence liver development and the broad spectrum of disease, from non-alcoholic fatty liver disease to fibrosis/cirrhosis, with particular emphasis on hepatic stellate cells and potential use of miRs as therapeutic tools.
文摘根据英国结构完整性评估标准BS7910(2013),考虑焊接残余应力影响,采用失效评估图(Failure Assessment Diagram,FAD)方法对镍基合金压力容器焊接部位内表面裂纹进行安全评估。首先采用有限元分析(Finite Element Analysis,FEA)方法,对压力容器V型、X型坡口环焊缝多层多道对接焊进行数值模拟,获取焊接残余应力分布,并将V型坡口对接焊焊接残余应力曲线与BS7910(2013)标准残余应力分布进行了对比;其次,对BS7910(2013)1级-FAC曲线进行公式化简,在焊接位置考虑残余应力、应力集中、塑性失效因子三因素的影响,对轴向内部半椭圆裂纹进行了失效应力预测。结果表明:残余应力的分布直接影响计算结果,残余拉应力越大,相应失效应力越小;残余应力值和裂纹深度a保持不变,失效应力计算结果随c/a(c为裂纹半长)增大而减小;当c/a比值不变,失效应力值随着a增大而减小。本文焊接残余应力模拟即及失效应力预测方法为以后含缺陷压力容器及管道失效应力计算(寿命预测)提供一定的参考。
