Hydrophilic poly(vinyl butyral)(PVB) /Pluronic F127(F127) blend hollow fiber membranes were prepared via thermally induced phase separation(TIPS) ,and the effects of blend composition on the performance of hydrophilic...Hydrophilic poly(vinyl butyral)(PVB) /Pluronic F127(F127) blend hollow fiber membranes were prepared via thermally induced phase separation(TIPS) ,and the effects of blend composition on the performance of hydrophilic PVB/F127 blend hollow fiber membrane were investigated.The addition of F127 to PVB/polyethylene glycol(PEG) system decreases the cloud point temperature,while the cloud point temperature increases slightly with the addition of F127 to 20%(by mass) PVB/F127/PEG200 system when the concentration of F127 is not higher than 5%(by mass) .Light scattering results show that the initial inter-phase periodic distance formed from the phase separation of 20%(by mass) PVB/F127/PEG200 system decreases with the addition of F127,so does the growth rate during cooling process.The blend hollow fiber membrane prepared at air-gap 5mm,of which the water permeability increases and the rejection changes little with the increase of F127 concentration.For the membrane prepared at zero air-gap,both water permeability and rejection of the PVB/F127 blend membrane are greater than those of PVB membrane,while the tensile strength changes little.Elementary analysis shows that most F127 in the polymer solution can firmly exist in the polymer matrix,increasing the hydrophilicity of the blend membrane prepared at air-gap of 5mm.展开更多
Retinal neovascularization is a leading cause of blindness.While current anti-VEGF drugs effectively inhibit pathological angiogenesis,some patients develop resistance or reduced responsiveness to treatments over time...Retinal neovascularization is a leading cause of blindness.While current anti-VEGF drugs effectively inhibit pathological angiogenesis,some patients develop resistance or reduced responsiveness to treatments over time,leading to diminished effectiveness.In this study,we identified high activation of the cGAS-STING signaling pathway,which exacerbated pathological neovascularization and vessel leakage.We developed an injectable thermo-responsive supramolecular hydrogel loaded with an anti-STING drug.The hydrogel,made of Pluronic F127 demonstrated excellent transparency and biocompatibility.Importantly,the thermo-sensitive property allowed for precise spatial release of the drug,extending the effective treatment duration of C-176,which suppressed STING activation in the retina,reduced inflammation and protected retinal tissue.Hydro^(C-176) effectively inhibited microglial cell infiltration and the release of inflammatory angiogenic factors,highlighting its enhanced efficacy.While demonstrating slightly lower effectiveness compared to traditional anti-VEGF therapy,Hydro^(C-176) exhibited more robust capabilities in regulating ocular microenvironmental inflammation.This approach may assist in enhancing the sensitivity and effectiveness of anti-VEGF therapy for reducing ocular inflammation,potentially improving patients’response to traditional treatment.These results have suggested innovative and comprehensive strategies for the management of retinal neovascularization.展开更多
To solve the volume expansion and poor electrical conductivity of germanium-based anode materials,Ge/rGO/CNTs nanocomposites with three-dimensional network structure are fabricated through the dispersion of polyethyle...To solve the volume expansion and poor electrical conductivity of germanium-based anode materials,Ge/rGO/CNTs nanocomposites with three-dimensional network structure are fabricated through the dispersion of polyethylene-polypropylene glycol(F127)and reduction of hydrogen.An interesting phenomenon is discovered that F127 can break GeO_(2)polycrystalline microparticles into 100 nm nanoparticles by only physical interaction,which promotes the uniform dispersion of GeO_(2)in a carbon network structure composed of graphene(rGO)and carbon nanotubes(CNTs).As evaluated as anode material of Lithium-ion batteries,Ge/rGO/CNTs nanocomposites exhibit excellent lithium storage performance.The initial specific capacity is high to 1549.7 mAh/g at 0.2 A/g,and the reversible capacity still retains972.4 mAh/g after 100 cycles.The improved lithium storage performance is attributed to that Ge nanoparticles can effectively slow down the volume expansion during charge and discharge processes,and threedimensional carbon networks can improve electrical conductivity and accelerate lithium-ion transfer of anode materials.展开更多
基金Supported by the National Natural Science Foundation of China（20776161）
文摘Hydrophilic poly(vinyl butyral)(PVB) /Pluronic F127(F127) blend hollow fiber membranes were prepared via thermally induced phase separation(TIPS) ,and the effects of blend composition on the performance of hydrophilic PVB/F127 blend hollow fiber membrane were investigated.The addition of F127 to PVB/polyethylene glycol(PEG) system decreases the cloud point temperature,while the cloud point temperature increases slightly with the addition of F127 to 20%(by mass) PVB/F127/PEG200 system when the concentration of F127 is not higher than 5%(by mass) .Light scattering results show that the initial inter-phase periodic distance formed from the phase separation of 20%(by mass) PVB/F127/PEG200 system decreases with the addition of F127,so does the growth rate during cooling process.The blend hollow fiber membrane prepared at air-gap 5mm,of which the water permeability increases and the rejection changes little with the increase of F127 concentration.For the membrane prepared at zero air-gap,both water permeability and rejection of the PVB/F127 blend membrane are greater than those of PVB membrane,while the tensile strength changes little.Elementary analysis shows that most F127 in the polymer solution can firmly exist in the polymer matrix,increasing the hydrophilicity of the blend membrane prepared at air-gap of 5mm.
基金This study was supported by grants from the National Natural Science Foundation of China(No.82271054,ZL,No.U20A20363,JH).
文摘Retinal neovascularization is a leading cause of blindness.While current anti-VEGF drugs effectively inhibit pathological angiogenesis,some patients develop resistance or reduced responsiveness to treatments over time,leading to diminished effectiveness.In this study,we identified high activation of the cGAS-STING signaling pathway,which exacerbated pathological neovascularization and vessel leakage.We developed an injectable thermo-responsive supramolecular hydrogel loaded with an anti-STING drug.The hydrogel,made of Pluronic F127 demonstrated excellent transparency and biocompatibility.Importantly,the thermo-sensitive property allowed for precise spatial release of the drug,extending the effective treatment duration of C-176,which suppressed STING activation in the retina,reduced inflammation and protected retinal tissue.Hydro^(C-176) effectively inhibited microglial cell infiltration and the release of inflammatory angiogenic factors,highlighting its enhanced efficacy.While demonstrating slightly lower effectiveness compared to traditional anti-VEGF therapy,Hydro^(C-176) exhibited more robust capabilities in regulating ocular microenvironmental inflammation.This approach may assist in enhancing the sensitivity and effectiveness of anti-VEGF therapy for reducing ocular inflammation,potentially improving patients’response to traditional treatment.These results have suggested innovative and comprehensive strategies for the management of retinal neovascularization.
基金financially supported by National Natural Science Foundation of China(Nos.22379056,52102100)Industry foresight and common key technology research in Carbon Peak and Carbon Neutrality Special Project from Zhenjiang city(No.CG2023003)Research and Practice Innovation Plan of Postgraduate Training Innovation Project in Jiangsu Province(No.SJCX23_2164)。
文摘To solve the volume expansion and poor electrical conductivity of germanium-based anode materials,Ge/rGO/CNTs nanocomposites with three-dimensional network structure are fabricated through the dispersion of polyethylene-polypropylene glycol(F127)and reduction of hydrogen.An interesting phenomenon is discovered that F127 can break GeO_(2)polycrystalline microparticles into 100 nm nanoparticles by only physical interaction,which promotes the uniform dispersion of GeO_(2)in a carbon network structure composed of graphene(rGO)and carbon nanotubes(CNTs).As evaluated as anode material of Lithium-ion batteries,Ge/rGO/CNTs nanocomposites exhibit excellent lithium storage performance.The initial specific capacity is high to 1549.7 mAh/g at 0.2 A/g,and the reversible capacity still retains972.4 mAh/g after 100 cycles.The improved lithium storage performance is attributed to that Ge nanoparticles can effectively slow down the volume expansion during charge and discharge processes,and threedimensional carbon networks can improve electrical conductivity and accelerate lithium-ion transfer of anode materials.
