Background： Although coronary heart disease （CHD） is one of the major cardiovascular diseases, risk factors associated with the health-related quality of life （HRQoL） of CHD patients remain unclear. The present s...Background： Although coronary heart disease （CHD） is one of the major cardiovascular diseases, risk factors associated with the health-related quality of life （HRQoL） of CHD patients remain unclear. The present study was designed to determine the profile and significant factors of the HRQoL in CHD patients.Methods： A cross-sectional study was conducted in rural communities of Fangshan District, Beijing. China. Socio-demographic, lifestyle, and comorbidity information of CHD patients were collected by a structured questionnaire and medical records. HRQoL was measured using European Quality of Life 5-dimensions （EQ-5D） scale and EQ Visual Analog Scale （EQ-VAS）. Multiple linear and logistic regressions were performed to explore the association of potential risk factors with HRQoL scores and each EQ-SD, respectively.Results： Totally, 1928 CHD patients （mean age 61.64 ± 9.24 years; female：male = 2.4：1） were enrolled in the study. The mean score of EQ-5D index and EQ-VAS were 0.889 ±0.172 and 71.56 ±17.65, respectively. Multiple linear regression revealed that marital status, physical activity, moderate alcohol drinking, and family＇s population were positive independent correlates of EQ-VAS, whereas diabetes mellitus and stroke were negative independent correlates （all P 〈 0.05）. Age and stroke were negatively while physical activity, moderate alcohol drinking, family＇s population and household income were positively correlated with EQ-5D index （all P 〈 0.05） independently. In addition, each of the five HRQoL dimensions had various specific determinants, including obesity, underweight. smoking or education. Conclusions： Findings of the study highlight certain socio-demographic, lifestyle factors, and comorbid stroke or diabetes mellitus as correlates of HRQoL in Chinese CHD patients. Large-scale cohort studies should be carried out to confirm our results in the future.展开更多
目的了解江苏省某市心脑血管疾病患病情况,探讨患病与不患病居民理想心血管健康水平(ideal cardiovascularhealth,ICVH)与健康相关生命质量(health-related quality of life,HRQoL)关系的特点,为开发心脑血管疾病风险防控的策略提供证...目的了解江苏省某市心脑血管疾病患病情况,探讨患病与不患病居民理想心血管健康水平(ideal cardiovascularhealth,ICVH)与健康相关生命质量(health-related quality of life,HRQoL)关系的特点,为开发心脑血管疾病风险防控的策略提供证据。方法本研究基于2019年宿迁市人群慢性病防控社会因素专项调查,纳入江苏省宿迁市18岁以上常住居民21815名。采用广义线性模型探讨ICVH水平和健康描述系统和欧洲健康量表(EQ-VAS)评分的相关关系。结果2.9%调查对象患有冠心病,4.2%患有卒中,0.9%同时患有冠心病和卒中。ICVH得分均数为(8.57±2.24)分,EQ-VAS均分为(75.70±11.62)分。广义线性模型结果显示,随着ICVH等级的升高,健康相关生命质量呈上升趋势;不同疾病组别中,无病组和脑卒中组ICVH得分及EQ-VAS得分差异有统计学意义。结论一般人群ICVH评分越高HRQoL越好,提示改善心脑血管健康可能有助于提高人群HRQoL。展开更多
目的分析2型糖尿病患者的EQ-5D结构效度,以进一步认识和应用。方法资料来自于2010年全国23个省(市)的103个临床试验中心调查资料,对象为9872例15岁及以上的口服降糖药物的2型糖尿病患者。采用验证性因子分析进行结构效度分析,并用PA-OV...目的分析2型糖尿病患者的EQ-5D结构效度,以进一步认识和应用。方法资料来自于2010年全国23个省(市)的103个临床试验中心调查资料,对象为9872例15岁及以上的口服降糖药物的2型糖尿病患者。采用验证性因子分析进行结构效度分析,并用PA-OV递归模型(Path analysis with observed variables)来探索生活质量影响因素。结果量表5个维度可以提取出2个公因子,分别命名为"主动生活质量"和"感知生活质量"。行动、平常活动和自我照顾三维度在"主动生活质量"上因子载荷分别为0.82、0.84和0.88,而疼痛、不舒服在"感知生活质量"上因子载荷分别为0.71和0.56,自我照顾存在跨因子现象。主动和感知生活质量2个初阶因子在"整体生活质量"上的因子载荷分别为0.66和0.88。一阶和二阶验证性因子分析模型适配度均较好,模型稳定。结论验证性因子分析能较好地评价EQ-5D结构效度,并能应用于2型糖尿病患者生活质量影响因素的探索。展开更多
基金Source of Support： This work was supported by grants from the National Natural Science Foundation of China （No. 81230066, No. 30872173, No. 81172744）. Conflict of Interest： None declared.
文摘Background： Although coronary heart disease （CHD） is one of the major cardiovascular diseases, risk factors associated with the health-related quality of life （HRQoL） of CHD patients remain unclear. The present study was designed to determine the profile and significant factors of the HRQoL in CHD patients.Methods： A cross-sectional study was conducted in rural communities of Fangshan District, Beijing. China. Socio-demographic, lifestyle, and comorbidity information of CHD patients were collected by a structured questionnaire and medical records. HRQoL was measured using European Quality of Life 5-dimensions （EQ-5D） scale and EQ Visual Analog Scale （EQ-VAS）. Multiple linear and logistic regressions were performed to explore the association of potential risk factors with HRQoL scores and each EQ-SD, respectively.Results： Totally, 1928 CHD patients （mean age 61.64 ± 9.24 years; female：male = 2.4：1） were enrolled in the study. The mean score of EQ-5D index and EQ-VAS were 0.889 ±0.172 and 71.56 ±17.65, respectively. Multiple linear regression revealed that marital status, physical activity, moderate alcohol drinking, and family＇s population were positive independent correlates of EQ-VAS, whereas diabetes mellitus and stroke were negative independent correlates （all P 〈 0.05）. Age and stroke were negatively while physical activity, moderate alcohol drinking, family＇s population and household income were positively correlated with EQ-5D index （all P 〈 0.05） independently. In addition, each of the five HRQoL dimensions had various specific determinants, including obesity, underweight. smoking or education. Conclusions： Findings of the study highlight certain socio-demographic, lifestyle factors, and comorbid stroke or diabetes mellitus as correlates of HRQoL in Chinese CHD patients. Large-scale cohort studies should be carried out to confirm our results in the future.
文摘目的了解江苏省某市心脑血管疾病患病情况,探讨患病与不患病居民理想心血管健康水平(ideal cardiovascularhealth,ICVH)与健康相关生命质量(health-related quality of life,HRQoL)关系的特点,为开发心脑血管疾病风险防控的策略提供证据。方法本研究基于2019年宿迁市人群慢性病防控社会因素专项调查,纳入江苏省宿迁市18岁以上常住居民21815名。采用广义线性模型探讨ICVH水平和健康描述系统和欧洲健康量表(EQ-VAS)评分的相关关系。结果2.9%调查对象患有冠心病,4.2%患有卒中,0.9%同时患有冠心病和卒中。ICVH得分均数为(8.57±2.24)分,EQ-VAS均分为(75.70±11.62)分。广义线性模型结果显示,随着ICVH等级的升高,健康相关生命质量呈上升趋势;不同疾病组别中,无病组和脑卒中组ICVH得分及EQ-VAS得分差异有统计学意义。结论一般人群ICVH评分越高HRQoL越好,提示改善心脑血管健康可能有助于提高人群HRQoL。
文摘目的分析2型糖尿病患者的EQ-5D结构效度,以进一步认识和应用。方法资料来自于2010年全国23个省(市)的103个临床试验中心调查资料,对象为9872例15岁及以上的口服降糖药物的2型糖尿病患者。采用验证性因子分析进行结构效度分析,并用PA-OV递归模型(Path analysis with observed variables)来探索生活质量影响因素。结果量表5个维度可以提取出2个公因子,分别命名为"主动生活质量"和"感知生活质量"。行动、平常活动和自我照顾三维度在"主动生活质量"上因子载荷分别为0.82、0.84和0.88,而疼痛、不舒服在"感知生活质量"上因子载荷分别为0.71和0.56,自我照顾存在跨因子现象。主动和感知生活质量2个初阶因子在"整体生活质量"上的因子载荷分别为0.66和0.88。一阶和二阶验证性因子分析模型适配度均较好,模型稳定。结论验证性因子分析能较好地评价EQ-5D结构效度,并能应用于2型糖尿病患者生活质量影响因素的探索。
