Objective：The programmed cell death-1 receptor/programmed cell death-1 ligand （PD-1/PD-L1） pathway plays a crucial role in tumor evasion from host immunity.This study was designed to evaluate the association betwee...Objective：The programmed cell death-1 receptor/programmed cell death-1 ligand （PD-1/PD-L1） pathway plays a crucial role in tumor evasion from host immunity.This study was designed to evaluate the association between circulating PD-L1 expression and prognosis in patients with advanced gastric cancer.Methods：Totally 80 advanced gastric cancer patients and 40 health controls from Beijing Cancer Hospital were enrolled in the present study.Circulating PD-L1 expression was tested by enzymelinked immunosorbent assay （ELISA）.The associations between the expression level of PD-L1 and clinicopathological features and prognosis were analyzed statistically.Results：Expression of PD-L1 in advanced gastric cancer patients was significandy up-regulated compared with health people （P=0.006）.The expression of PD-L1 was significantly correlated with differentiation and lymph node metastasis （P=0.026 and P=0.041,respectively）.Although we didn＇t find significant difference in all advanced gastric cancer patients with different PD-L1 expression,the adenocarcinoma patients with higher up-regulated PD-L1 expression had much better prognosis than low expression patients （65.6％ vs.44.7％,P=0.028）.Conclusions：PD-L1 was elevated in advance gastric cancer patients and may play an important role in tumor immune evasion and patients prognosis.展开更多
目的 探讨溃疡性结肠炎(UC)患者白介素13(IL13)和一氧化氮(NO)的作用和相互关系。方法 采用硝酸还原法和ELIAS分别检测血清NO浓度和血浆IL-13浓度。结果 31例UC患者和30例健康人血浆IL-13(pg/ml)(16.65±3.38 vs 25.83±3.59)...目的 探讨溃疡性结肠炎(UC)患者白介素13(IL13)和一氧化氮(NO)的作用和相互关系。方法 采用硝酸还原法和ELIAS分别检测血清NO浓度和血浆IL-13浓度。结果 31例UC患者和30例健康人血浆IL-13(pg/ml)(16.65±3.38 vs 25.83±3.59)或血清NO浓度(μml/L)(66.65±8.38 vs 59.83±8.59)比较,差异有显著性(P<0.05)。活动期(21例)和静止期(10例)UC患者血浆IL-13浓度(pg/ml)(12.03±3.72 vs 18.67±4.22)或血清NO浓度(μml/L)(69.03±8.72 vs 61.67±4.92)比较,差异有显著性(P<0.05)。轻、中、重度活动期UC血浆IL-13浓度(pg/ml)(13.35±2.98,8.12±1.56,4.57±1.36)或血清NO浓度(μml/L)(60.35±4.98,69.12±6.56,77.57±5.76)相互间比较,差异有显著性(P<0.05)。UC患者血清C-RP浓度与血浆IL-13呈负相关(r=-0.598.P<0.01),而与血清NO浓度呈正相关(r=0.799,P<0.01)。血清NO浓度和血浆IL-13浓度呈负相关(r=-0.632,P<0.01)。结论血浆IL-13和血清NO可作为判断UC患者病变严重程度和复发的指标之一。IL-13可能参与肠粘膜上皮细胞内调节NO产生的机制。展开更多
文摘Objective：The programmed cell death-1 receptor/programmed cell death-1 ligand （PD-1/PD-L1） pathway plays a crucial role in tumor evasion from host immunity.This study was designed to evaluate the association between circulating PD-L1 expression and prognosis in patients with advanced gastric cancer.Methods：Totally 80 advanced gastric cancer patients and 40 health controls from Beijing Cancer Hospital were enrolled in the present study.Circulating PD-L1 expression was tested by enzymelinked immunosorbent assay （ELISA）.The associations between the expression level of PD-L1 and clinicopathological features and prognosis were analyzed statistically.Results：Expression of PD-L1 in advanced gastric cancer patients was significandy up-regulated compared with health people （P=0.006）.The expression of PD-L1 was significantly correlated with differentiation and lymph node metastasis （P=0.026 and P=0.041,respectively）.Although we didn＇t find significant difference in all advanced gastric cancer patients with different PD-L1 expression,the adenocarcinoma patients with higher up-regulated PD-L1 expression had much better prognosis than low expression patients （65.6％ vs.44.7％,P=0.028）.Conclusions：PD-L1 was elevated in advance gastric cancer patients and may play an important role in tumor immune evasion and patients prognosis.
文摘目的 探讨溃疡性结肠炎(UC)患者白介素13(IL13)和一氧化氮(NO)的作用和相互关系。方法 采用硝酸还原法和ELIAS分别检测血清NO浓度和血浆IL-13浓度。结果 31例UC患者和30例健康人血浆IL-13(pg/ml)(16.65±3.38 vs 25.83±3.59)或血清NO浓度(μml/L)(66.65±8.38 vs 59.83±8.59)比较,差异有显著性(P<0.05)。活动期(21例)和静止期(10例)UC患者血浆IL-13浓度(pg/ml)(12.03±3.72 vs 18.67±4.22)或血清NO浓度(μml/L)(69.03±8.72 vs 61.67±4.92)比较,差异有显著性(P<0.05)。轻、中、重度活动期UC血浆IL-13浓度(pg/ml)(13.35±2.98,8.12±1.56,4.57±1.36)或血清NO浓度(μml/L)(60.35±4.98,69.12±6.56,77.57±5.76)相互间比较,差异有显著性(P<0.05)。UC患者血清C-RP浓度与血浆IL-13呈负相关(r=-0.598.P<0.01),而与血清NO浓度呈正相关(r=0.799,P<0.01)。血清NO浓度和血浆IL-13浓度呈负相关(r=-0.632,P<0.01)。结论血浆IL-13和血清NO可作为判断UC患者病变严重程度和复发的指标之一。IL-13可能参与肠粘膜上皮细胞内调节NO产生的机制。
